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@article{1408645,
author = {Vagnerova, R. and Lukesova, A. and Lukes, M. and Roznovska, P. and Hola, M. and Fulneckova, J. and Fajkus, Jiří and Angelis, K.J.},
article_location = {BASEL},
article_number = {11},
doi = {http://dx.doi.org/10.3390/genes8110331},
keywords = {Physcomitrella patens; Klebsormidium; Zygnema; DNA damage and repair; bleomycin; methyl methanesulfonate; ultraviolet light},
language = {eng},
issn = {2073-4425},
journal = {GENES},
title = {Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress},
url = {http://www.mdpi.com/2073-4425/8/11/331},
volume = {8},
year = {2017}
}
TY - JOUR
ID - 1408645
AU - Vagnerova, R. - Lukesova, A. - Lukes, M. - Roznovska, P. - Hola, M. - Fulneckova, J. - Fajkus, Jiří - Angelis, K.J.
PY - 2017
TI - Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress
JF - GENES
VL - 8
IS - 11
SP - nestránkováno
EP - nestránkováno
PB - MDPI AG
SN - 20734425
KW - Physcomitrella patens
KW - Klebsormidium
KW - Zygnema
KW - DNA damage and repair
KW - bleomycin
KW - methyl methanesulfonate
KW - ultraviolet light
UR - http://www.mdpi.com/2073-4425/8/11/331
N2 - Research in algae usually focuses on the description and characterization of morphoand phenotype as a result of adaptation to a particular habitat and its conditions. To better understand the evolution of lineages we characterized responses of filamentous streptophyte green algae of the genera Klebsormidium and Zygnema, and of a land plantthe moss Physcomitrella patensto genotoxic stress that might be relevant to their environment. We studied the induction and repair of DNA double strand breaks (DSBs) elicited by the radiomimetic drug bleomycin, DNA single strand breaks (SSB) as consequence of base modification by the alkylation agent methyl methanesulfonate (MMS) and of ultra violet (UV)-induced photo-dimers, because the mode of action of these three genotoxic agents is well understood. We show that the Klebsormidium and Physcomitrella are similarly sensitive to introduced DNA lesions and have similar rates of DSBs repair. In contrast, less DNA damage and higher repair rate of DSBs was detected in Zygnema, suggesting different mechanisms of maintaining genome integrity in response to genotoxic stress. Nevertheless, contrary to fewer detected lesions is Zygnema more sensitive to genotoxic treatment than Klebsormidium and Physcomitrella
ER -
VAGNEROVA, R., A. LUKESOVA, M. LUKES, P. ROZNOVSKA, M. HOLA, J. FULNECKOVA, Jiří FAJKUS a K.J. ANGELIS. Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress. \textit{GENES}. BASEL: MDPI AG, roč.~8, č.~11, s.~nestránkováno, 13 s. ISSN~2073-4425. doi:10.3390/genes8110331. 2017.
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