Histone MacroH2A1: A Chromatin Point of Intersection between
Fasting, Senescence and Cellular Regeneration

J 2017

Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular Regeneration

LO RE, Oriana a Manlio VINCIGUERRA

Základní údaje

Originální název

Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular Regeneration

Autoři

LO RE, Oriana a Manlio VINCIGUERRA

Vydání

GENES, BASEL, MDPI AG, 2017, 2073-4425

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30101 Human genetics

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.191

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/17:00100114

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

histone variant macroH2A1; fasting; senescence; regeneration

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 2. 2018 15:09, Soňa Böhmová

Anotace

V originále

Histone variants confer chromatin unique properties. They have specific genomic distribution, regulated by specific deposition and removal machineries. Histone variants, mostly of canonical histones H2A, H2B and H3, have important roles in early embryonic development, in lineage commitment of stem cells, in the converse process of somatic cell reprogramming to pluripotency and, in some cases, in the modulation of animal aging and life span. MacroH2A1 is a variant of histone H2A, present in two alternatively exon-spliced isoforms macroH2A1.1 and macroH2A1.2, regulating cell plasticity and proliferation, during pluripotency and tumorigenesis. Furthermore, macroH2A1 participates in the formation of senescence-associated heterochromatic foci (SAHF) in senescent cells, and multiple lines of evidence in genetically modified mice suggest that macroH2A1 integrates nutritional cues from the extracellular environment to transcriptional programs. Here, we review current molecular evidence based on next generation sequencing data, cell assays and in vivo models supporting different mechanisms that could mediate the function of macroH2A1 in health span and life span. We will further discuss context-dependent and isoform-specific functions. The aim of this review is to provide guidance to assess histone variant macroH2A1 potential as a therapeutic intervention point.

Citovat

LO RE, Oriana a Manlio VINCIGUERRA. Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular Regeneration. GENES. BASEL: MDPI AG, 2017, roč. 8, č. 12, s. 1-14. ISSN 2073-4425. Dostupné z: https://doi.org/10.3390/genes8120367.

@article{1409414,
   author = {Lo Re, Oriana and Vinciguerra, Manlio},
   article_location = {BASEL},
   article_number = {12},
   doi = {https://doi.org/10.3390/genes8120367},
   keywords = {histone variant macroH2A1; fasting; senescence; regeneration},
   language = {eng},
   issn = {2073-4425},
   journal = {GENES},
   title = {Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular Regeneration},
   volume = {8},
   year = {2017}
}

TY  - JOUR
ID  - 1409414
AU  - Lo Re, Oriana - Vinciguerra, Manlio
PY  - 2017
TI  - Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular Regeneration
JF  - GENES
VL  - 8
IS  - 12
SP  - 1-14
EP  - 1-14
PB  - MDPI AG
SN  - 20734425
KW  - histone variant macroH2A1
KW  - fasting
KW  - senescence
KW  - regeneration
N2  - Histone variants confer chromatin unique properties. They have specific genomic distribution, regulated by specific deposition and removal machineries. Histone variants, mostly of canonical histones H2A, H2B and H3, have important roles in early embryonic development, in lineage commitment of stem cells, in the converse process of somatic cell reprogramming to pluripotency and, in some cases, in the modulation of animal aging and life span. MacroH2A1 is a variant of histone H2A, present in two alternatively exon-spliced isoforms macroH2A1.1 and macroH2A1.2, regulating cell plasticity and proliferation, during pluripotency and tumorigenesis. Furthermore, macroH2A1 participates in the formation of senescence-associated heterochromatic foci (SAHF) in senescent cells, and multiple lines of evidence in genetically modified mice suggest that macroH2A1 integrates nutritional cues from the extracellular environment to transcriptional programs. Here, we review current molecular evidence based on next generation sequencing data, cell assays and in vivo models supporting different mechanisms that could mediate the function of macroH2A1 in health span and life span. We will further discuss context-dependent and isoform-specific functions. The aim of this review is to provide guidance to assess histone variant macroH2A1 potential as a therapeutic intervention point.
ER  -

LO RE, Oriana a Manlio VINCIGUERRA. Histone MacroH2A1: A Chromatin Point of Intersection between Fasting, Senescence and Cellular Regeneration. \textit{GENES}. BASEL: MDPI AG, 2017, roč.~8, č.~12, s.~1-14. ISSN~2073-4425. Dostupné z: https://doi.org/10.3390/genes8120367.

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