Polyaniline cryogels: Biocompatibility of novel conducting
macroporous material

J 2018

Polyaniline cryogels: Biocompatibility of novel conducting macroporous material

HUMPOLÍČEK, Petr; Katarzyna Anna RADASZKIEWICZ; Zdenka CAPÁKOVÁ; Jiří PACHERNÍK; Patrycja BOBER et al.

Základní údaje

Originální název

Polyaniline cryogels: Biocompatibility of novel conducting macroporous material

Autoři

HUMPOLÍČEK, Petr; Katarzyna Anna RADASZKIEWICZ; Zdenka CAPÁKOVÁ; Jiří PACHERNÍK; Patrycja BOBER; Věra KAŠPÁRKOVÁ; Petra REJMONTOVÁ; Marián LEHOCKÝ; Petr PONÍŽIL a Jaroslav STEJSKAL

Vydání

Scientific Reports, Nature Publishing Group, 2018, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.011

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/18:00102353

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Biomaterials cells

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 23. 4. 2024 11:04, Mgr. Michal Petr

Anotace

V originále

Polyaniline cryogel is a new unique form of polyaniline combining intrinsic electrical conductivity and the material properties of hydrogels. It is prepared by the polymerization of aniline in frozen poly(vinyl alcohol) solutions. The biocompatibility of macroporous polyaniline cryogel was demonstrated by testing its cytotoxicity on mouse embryonic fibroblasts and via the test of embryotoxicity based on the formation of beating foci within spontaneous differentiating embryonic stem cells. Good biocompatibility was related to low contents of low-molecular-weight impurities in polyaniline cryogel, which was confirmed by liquid chromatography. The adhesion and growth of embryonic stem cells, embryoid bodies, cardiomyocytes, and neural progenitors prove that polyaniline cryogel has the potential to be used as a carrier for cells in tissue engineering or bio-sensing. The surface energy as well as the elasticity and porosity of cryogel mimic tissue properties. Polyaniline cryogel can therefore be applied in bio-sensing or regenerative medicine in general, and mainly in the tissue engineering of electrically excitable tissues.

Citovat

HUMPOLÍČEK, Petr; Katarzyna Anna RADASZKIEWICZ; Zdenka CAPÁKOVÁ; Jiří PACHERNÍK; Patrycja BOBER; Věra KAŠPÁRKOVÁ; Petra REJMONTOVÁ; Marián LEHOCKÝ; Petr PONÍŽIL a Jaroslav STEJSKAL. Polyaniline cryogels: Biocompatibility of novel conducting macroporous material. Scientific Reports. Nature Publishing Group, 2018, roč. 8, č. 135, s. 1-12. ISSN 2045-2322. Dostupné z: https://doi.org/10.1038/s41598-017-18290-1.

@article{1409694,
   author = {Humpolíček, Petr and Radaszkiewicz, Katarzyna Anna and Capáková, Zdenka and Pacherník, Jiří and Bober, Patrycja and Kašpárková, Věra and Rejmontová, Petra and Lehocký, Marián and Ponížil, Petr and Stejskal, Jaroslav},
   article_number = {135},
   doi = {https://doi.org/10.1038/s41598-017-18290-1},
   keywords = {Biomaterials cells},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Polyaniline cryogels: Biocompatibility of novel conducting macroporous material},
   url = {https://www.nature.com/articles/s41598-017-18290-1#author-information},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1409694
AU  - Humpolíček, Petr - Radaszkiewicz, Katarzyna Anna - Capáková, Zdenka - Pacherník, Jiří - Bober, Patrycja - Kašpárková, Věra - Rejmontová, Petra - Lehocký, Marián - Ponížil, Petr - Stejskal, Jaroslav
PY  - 2018
TI  - Polyaniline cryogels: Biocompatibility of novel conducting macroporous material
JF  - Scientific Reports
VL  - 8
IS  - 135
SP  - 1-12
EP  - 1-12
PB  - Nature Publishing Group
SN  - 20452322
KW  - Biomaterials cells
UR  - https://www.nature.com/articles/s41598-017-18290-1#author-information
N2  - Polyaniline cryogel is a new unique form of polyaniline combining intrinsic electrical conductivity and the material properties of hydrogels. It is prepared by the polymerization of aniline in frozen poly(vinyl alcohol) solutions. The biocompatibility of macroporous polyaniline cryogel was demonstrated by testing its cytotoxicity on mouse embryonic fibroblasts and via the test of embryotoxicity based on the formation of beating foci within spontaneous differentiating embryonic stem cells. Good biocompatibility was related to low contents of low-molecular-weight impurities in polyaniline cryogel, which was confirmed by liquid chromatography. The adhesion and growth of embryonic stem cells, embryoid bodies, cardiomyocytes, and neural progenitors prove that polyaniline cryogel has the potential to be used as a carrier for cells in tissue engineering or bio-sensing. The surface energy as well as the elasticity and porosity of cryogel mimic tissue properties. Polyaniline cryogel can therefore be applied in bio-sensing or regenerative medicine in general, and mainly in the tissue engineering of electrically excitable tissues.
ER  -

HUMPOLÍČEK, Petr; Katarzyna Anna RADASZKIEWICZ; Zdenka CAPÁKOVÁ; Jiří PACHERNÍK; Patrycja BOBER; Věra KAŠPÁRKOVÁ; Petra REJMONTOVÁ; Marián LEHOCKÝ; Petr PONÍŽIL a Jaroslav STEJSKAL. Polyaniline cryogels: Biocompatibility of novel conducting macroporous material. \textit{Scientific Reports}. Nature Publishing Group, 2018, roč.~8, č.~135, s.~1-12. ISSN~2045-2322. Dostupné z: https://doi.org/10.1038/s41598-017-18290-1.

Přehled o publikaci