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@article{1411022,
author = {Davey, M.S. and Willcox, C.R. and Joyce, S.P. and Ladell, K. and Kasatskaya, S.A. and McLaren, J.E. and Hunter, S. and Salim, M. and Mohammed, F. and Price, D.A. and Chudakov, Dmitriy and Willcox, B.E.},
article_location = {London},
article_number = {MAR},
doi = {http://dx.doi.org/10.1038/ncomms14760},
keywords = {STRESS-SURVEILLANCE; ANTIGEN RECOGNITION; CYTOMEGALOVIRUS; RECEPTOR; TRANSPLANTATION; INFECTION; COMPLEX; MEMORY; AGE; DIFFERENTIATION},
language = {eng},
issn = {2041-1723},
journal = {Nature Communications},
title = {Clonal selection in the human V delta 1 T cell repertoire indicates gamma delta TCR-dependent adaptive immune surveillance},
url = {https://www.nature.com/articles/ncomms14760.pdf},
volume = {8},
year = {2017}
}
TY - JOUR
ID - 1411022
AU - Davey, M.S. - Willcox, C.R. - Joyce, S.P. - Ladell, K. - Kasatskaya, S.A. - McLaren, J.E. - Hunter, S. - Salim, M. - Mohammed, F. - Price, D.A. - Chudakov, Dmitriy - Willcox, B.E.
PY - 2017
TI - Clonal selection in the human V delta 1 T cell repertoire indicates gamma delta TCR-dependent adaptive immune surveillance
JF - Nature Communications
VL - 8
IS - MAR
SP - 14760
EP - 14760
PB - Nature Publishing Group
SN - 20411723
KW - STRESS-SURVEILLANCE
KW - ANTIGEN RECOGNITION
KW - CYTOMEGALOVIRUS
KW - RECEPTOR
KW - TRANSPLANTATION
KW - INFECTION
KW - COMPLEX
KW - MEMORY
KW - AGE
KW - DIFFERENTIATION
UR - https://www.nature.com/articles/ncomms14760.pdf
L2 - https://www.nature.com/articles/ncomms14760.pdf
N2 - gamma delta Tcells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human V delta 2(neg) T cells, implicated in responses to viral infection and cancer. The prevalent V delta 1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, V delta 2(+) T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human V delta 1(+) T cells have therefore evolved a distinct biology from the V delta 2(+) subset, involving a central, personalized role for the gamma delta TCR in directing a highly adaptive yet unconventional form of immune surveillance.
ER -
DAVEY, M.S., C.R. WILLCOX, S.P. JOYCE, K. LADELL, S.A. KASATSKAYA, J.E. MCLAREN, S. HUNTER, M. SALIM, F. MOHAMMED, D.A. PRICE, Dmitriy CHUDAKOV a B.E. WILLCOX. Clonal selection in the human V delta 1 T cell repertoire indicates gamma delta TCR-dependent adaptive immune surveillance. \textit{Nature Communications}. London: Nature Publishing Group, 2017, roč.~8, MAR, s.~14760-14774. ISSN~2041-1723. Dostupné z: https://dx.doi.org/10.1038/ncomms14760.
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