The rs1527483, but not rs3212018, CD36 polymorphism associates
with linoleic acid detection and obesity in Czech young adults.

J 2018

The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults.

PLESNÍK, Jiří; Omar ŠERÝ; Amira KHAN; Peter BIELIK; Naim Akhtar KHAN et al.

Základní údaje

Originální název

The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults.

Autoři

PLESNÍK, Jiří; Omar ŠERÝ; Amira KHAN; Peter BIELIK a Naim Akhtar KHAN

Vydání

British Journal of Nutrition, Cambridge University Press, 2018, 0007-1145

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.319

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/18:00102403

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

CD36; fat taste; genetic; polymorphism; rs1527483

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 4. 2020 13:22, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Recent evidence has raised the possibility of the existence of a sixth taste modality – that is, taste for fat – which is mediated by lingual CD36 and plays a role in obesity. In the present study, we investigated the relationship between oro-sensory perception of linoleic acid (LA), two CD36 polymorphisms (rs1527483 and rs3212018), obesity parameters and craving habits for dietary lipids in young Czech adults. We observed that craving for dietary lipids was correlated with anthropometric parameters (P<0·05) and LA detection threshold (P=0·033). The participants with the CC genotype of the rs1527483 polymorphism had lower BMI (P=0·011), waist circumference (P=0·005), waist:height ratio (P=0·010) and higher sensitivity for LA (P=0·037) than the participants with the CT and TT genotypes. Interestingly, we did not observe any association between the rs3212018 polymorphism and the studied parameters. Moreover, we did not observe any mutation in exons 5 and 6 of the CD36 gene in these subjects. Finally, we can state that rs1527483 is associated with high body weight in young Czech subjects.

Návaznosti

MUNI/A/1278/2016, interní kód MU

Název: Podpora biochemického výzkumu v roce 2017

Investor: Masarykova univerzita, Podpora biochemického výzkumu v roce 2017, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

PLESNÍK, Jiří; Omar ŠERÝ; Amira KHAN; Peter BIELIK a Naim Akhtar KHAN. The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults. British Journal of Nutrition. Cambridge University Press, 2018, roč. 119, č. 4, s. 472-478. ISSN 0007-1145. Dostupné z: https://doi.org/10.1017/S0007114517003981.

@article{1411268,
   author = {Plesník, Jiří and Šerý, Omar and Khan, Amira and Bielik, Peter and Khan, Naim Akhtar},
   article_number = {4},
   doi = {https://doi.org/10.1017/S0007114517003981},
   keywords = {CD36; fat taste; genetic; polymorphism; rs1527483},
   language = {eng},
   issn = {0007-1145},
   journal = {British Journal of Nutrition},
   title = {The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults.},
   url = {https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/rs1527483-but-not-rs3212018-cd36-polymorphism-associates-with-linoleic-acid-detection-and-obesity-in-czech-young-adults/101BFA8F49E7ABAF805F75A1CA2F2A82},
   volume = {119},
   year = {2018}
}

TY  - JOUR
ID  - 1411268
AU  - Plesník, Jiří - Šerý, Omar - Khan, Amira - Bielik, Peter - Khan, Naim Akhtar
PY  - 2018
TI  - The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults.
JF  - British Journal of Nutrition
VL  - 119
IS  - 4
SP  - 472-478
EP  - 472-478
PB  - Cambridge University Press
SN  - 00071145
KW  - CD36
KW  - fat taste
KW  - genetic
KW  - polymorphism
KW  - rs1527483
UR  - https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/rs1527483-but-not-rs3212018-cd36-polymorphism-associates-with-linoleic-acid-detection-and-obesity-in-czech-young-adults/101BFA8F49E7ABAF805F75A1CA2F2A82
L2  - https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/rs1527483-but-not-rs3212018-cd36-polymorphism-associates-with-linoleic-acid-detection-and-obesity-in-czech-young-adults/101BFA8F49E7ABAF805F75A1CA2F2A82
N2  - Recent evidence has raised the possibility of the existence of a sixth taste modality – that is, taste for fat – which is mediated by lingual CD36 and plays a role in obesity. In the present study, we investigated the relationship between oro-sensory perception of linoleic acid (LA), two CD36 polymorphisms (rs1527483 and rs3212018), obesity parameters and craving habits for dietary lipids in young Czech adults. We observed that craving for dietary lipids was correlated with anthropometric parameters (P<0·05) and LA detection threshold (P=0·033). The participants with the CC genotype of the rs1527483 polymorphism had lower BMI (P=0·011), waist circumference (P=0·005), waist:height ratio (P=0·010) and higher sensitivity for LA (P=0·037) than the participants with the CT and TT genotypes. Interestingly, we did not observe any association between the rs3212018 polymorphism and the studied parameters. Moreover, we did not observe any mutation in exons 5 and 6 of the CD36 gene in these subjects. Finally, we can state that rs1527483 is associated with high body weight in young Czech subjects.
ER  -

PLESNÍK, Jiří; Omar ŠERÝ; Amira KHAN; Peter BIELIK a Naim Akhtar KHAN. The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults. \textit{British Journal of Nutrition}. Cambridge University Press, 2018, roč.~119, č.~4, s.~472-478. ISSN~0007-1145. Dostupné z: https://doi.org/10.1017/S0007114517003981.

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