Could ethanol-induced alterations in the expression of
glutamate transporters in testes contribute to the effect of
paternal drinking on the risk of abnormalities in the
offspring?

J 2017

Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring?

KASHEM, Abdul Mohammed, Aven LEE, David V. POW, Omar ŠERÝ, Vladimír Josef BALCAR et. al.

Základní údaje

Originální název

Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring?

Autoři

KASHEM, Abdul Mohammed (36 Austrálie), Aven LEE (36 Austrálie), David V. POW (36 Austrálie), Omar ŠERÝ (203 Česká republika, garant, domácí) a Vladimír Josef BALCAR (36 Austrálie)

Vydání

Medical Hypotheses, EDINBURGH, Churchill Livingstone, 2017, 0306-9877

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.120

Kód RIV

RIV/00216224:14310/17:00100376

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.mehy.2016.11.015

UT WoS

000393001900015

Klíčová slova anglicky

ALCOHOL EXPOSURE; BRAIN; RAT; RECEPTORS; TRANSMISSION; CONSUMPTION; INSIGHTS; CELLS

Štítky

NZ, rivok

Změněno: 30. 3. 2018 22:32, Ing. Nicole Zrilić

Anotace

V originále

It has been known that a preconception paternal alcoholism impacts adversely on the offspring but the mechanism of the effect is uncertain. Several findings suggest that there are signalling systems in testis that are analogous to those known to be altered by alcoholism in brain. We propose that chronic alcohol affects these systems in a manner similar to that in brain. Specifically, we hypothesise that excessive alcohol may disturb glutamatergic-like signalling in testis by increasing expression of the glutamate transporter GLAST (EAAT1). We discuss ways how to test the hypothesis as well as potential significance of some of the tests as tools in the diagnostics of chronic alcoholism.

Návaznosti

MUNI/A/1278/2016, interní kód MU

Název: Podpora biochemického výzkumu v roce 2017

Investor: Masarykova univerzita, Podpora biochemického výzkumu v roce 2017, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

KASHEM, Abdul Mohammed, Aven LEE, David V. POW, Omar ŠERÝ a Vladimír Josef BALCAR. Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring? Medical Hypotheses. EDINBURGH: Churchill Livingstone, 2017, roč. 98, January, s. 57-59. ISSN 0306-9877. Dostupné z: https://dx.doi.org/10.1016/j.mehy.2016.11.015.

@article{1411279,
   author = {Kashem, Abdul Mohammed and Lee, Aven and Pow, David V. and Šerý, Omar and Balcar, Vladimír Josef},
   article_location = {EDINBURGH},
   article_number = {January},
   doi = {http://dx.doi.org/10.1016/j.mehy.2016.11.015},
   keywords = {ALCOHOL EXPOSURE; BRAIN; RAT; RECEPTORS; TRANSMISSION; CONSUMPTION; INSIGHTS; CELLS},
   language = {eng},
   issn = {0306-9877},
   journal = {Medical Hypotheses},
   title = {Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring?},
   volume = {98},
   year = {2017}
}

TY  - JOUR
ID  - 1411279
AU  - Kashem, Abdul Mohammed - Lee, Aven - Pow, David V. - Šerý, Omar - Balcar, Vladimír Josef
PY  - 2017
TI  - Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring?
JF  - Medical Hypotheses
VL  - 98
IS  - January
SP  - 57-59
EP  - 57-59
PB  - Churchill Livingstone
SN  - 03069877
KW  - ALCOHOL EXPOSURE
KW  - BRAIN
KW  - RAT
KW  - RECEPTORS
KW  - TRANSMISSION
KW  - CONSUMPTION
KW  - INSIGHTS
KW  - CELLS
N2  - It has been known that a preconception paternal alcoholism impacts adversely on the offspring but the mechanism of the effect is uncertain. Several findings suggest that there are signalling systems in testis that are analogous to those known to be altered by alcoholism in brain. We propose that chronic alcohol affects these systems in a manner similar to that in brain. Specifically, we hypothesise that excessive alcohol may disturb glutamatergic-like signalling in testis by increasing expression of the glutamate transporter GLAST (EAAT1). We discuss ways how to test the hypothesis as well as potential significance of some of the tests as tools in the diagnostics of chronic alcoholism.
ER  -

KASHEM, Abdul Mohammed, Aven LEE, David V. POW, Omar ŠERÝ a Vladimír Josef BALCAR. Could ethanol-induced alterations in the expression of glutamate transporters in testes contribute to the effect of paternal drinking on the risk of abnormalities in the offspring? \textit{Medical Hypotheses}. EDINBURGH: Churchill Livingstone, 2017, roč.~98, January, s.~57-59. ISSN~0306-9877. Dostupné z: https://dx.doi.org/10.1016/j.mehy.2016.11.015.

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