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@proceedings{1411819,
author = {de la Cruz, F.F. and Šmída, Michal and Nijman, M.},
booktitle = {AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer},
doi = {http://dx.doi.org/10.1158/1538-8514.SYNTHLETH-PR14},
keywords = {MEK inhibitors; ATM},
language = {eng},
title = {MEK inhibitors block growth of Ataxia Telangiectasia Mutated (ATM) mutant lung tumors},
url = {http://mct.aacrjournals.org/content/16/10_Supplement/PR14},
year = {2017}
}
TY - CONF
ID - 1411819
AU - de la Cruz, F.F. - Šmída, Michal - Nijman, M.
PY - 2017
TI - MEK inhibitors block growth of Ataxia Telangiectasia Mutated (ATM) mutant lung tumors
KW - MEK inhibitors
KW - ATM
UR - http://mct.aacrjournals.org/content/16/10_Supplement/PR14
L2 - http://mct.aacrjournals.org/content/16/10_Supplement/PR14
N2 - Introduction: Lung cancer is the leading cause of cancer death worldwide. In the past decade, deep sequencing projects have shed light on the molecular drivers commonly found altered in NSCLC. As a result, the first molecularly targeted agents have been approved for the treatment of tumors presenting activating oncogenic events in EGFR or EML4/ALK. However, the translation into therapies for tumors presenting loss-of-function mutations has proven challenging and constitutes an unexplored and promising field. In order to narrow the gap between cancer genomics and effective treatments for tumors harboring mutations in well-defined tumor suppressor genes (such as PTEN, BRG1 or ATM), we have developed a genetically tractable lung cancer cell model. Focusing on lung adenocarcinoma, we have engineered a panel of isogenic cell lines capturing the molecular heterogeneity found in patients. This panel has been screened against a collection of drugs, comprising classical chemotherapeutics and kinase inhibitors, providing a comprehensive evaluation for hundreds of gene-drug interactions.
ER -
DE LA CRUZ, F.F., Michal ŠMÍDA a M. NIJMAN. MEK inhibitors block growth of Ataxia Telangiectasia Mutated (ATM) mutant lung tumors. In \textit{AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer}. 2017. ISSN~1535-7163. Dostupné z: https://dx.doi.org/10.1158/1538-8514.SYNTHLETH-PR14.
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