Role of substance P in the cardiovascular system

J 2016

Role of substance P in the cardiovascular system

MISTROVA, Eliska; Peter KRUŽLIAK a Magdalena DVORAKOVA CHOTTOVA

Základní údaje

Originální název

Role of substance P in the cardiovascular system

Autoři

MISTROVA, Eliska; Peter KRUŽLIAK a Magdalena DVORAKOVA CHOTTOVA

Vydání

NEUROPEPTIDES, EDINBURGH, CHURCHILL LIVINGSTONE, 2016, 0143-4179

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30202 Endocrinology and metabolism

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.486

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/16:00100473

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Substance P; NK1 receptor; Cardiovascular regulation; Antagonist

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 5. 2018 15:16, Soňa Böhmová

Anotace

V originále

This article provides an overview of the structure and function of substance P signalling system and its involvement in the cardiovascular regulation. Substance P is an undecapeptide originating from TAC1 gen and belonging to the tachykinin family. The biological actions of substance P are mainly mediated through neurokinin receptor 1 since substance P is the ligand with the highest affinity to neurokinin receptor 1. Substance P is widely distributed within the central and peripheral nervous systems as well as in the cardiovascular system. Substance P is involved in the regulation of heart frequency, blood pressure and in the stretching of vessels. Substance P plays an important role in ischemia and reperfusion and cardiovascular response to stress. Additionally, it has been also implicated in angiogenesis, pain transmission and inflammation. The substance P/neurokinin receptor 1 receptor system is involved in the molecular bases of many human pathological processes. Antagonists of neurokinin receptor 1 receptor could provide clinical solutions for a variety of diseases. Neurokinin receptor 1 antagonists are already used in the prevention of chemotherapy induced nausea and vomiting. (C) 2015 Elsevier Ltd. All rights reserved.

Citovat

MISTROVA, Eliska; Peter KRUŽLIAK a Magdalena DVORAKOVA CHOTTOVA. Role of substance P in the cardiovascular system. NEUROPEPTIDES. EDINBURGH: CHURCHILL LIVINGSTONE, 2016, roč. 58, AUG 2016, s. 41-51. ISSN 0143-4179. Dostupné z: https://doi.org/10.1016/j.npep.2015.12.005.

@article{1412145,
   author = {Mistrova, Eliska and Kružliak, Peter and Dvorakova Chottova, Magdalena},
   article_location = {EDINBURGH},
   article_number = {AUG 2016},
   doi = {https://doi.org/10.1016/j.npep.2015.12.005},
   keywords = {Substance P; NK1 receptor; Cardiovascular regulation; Antagonist},
   language = {eng},
   issn = {0143-4179},
   journal = {NEUROPEPTIDES},
   title = {Role of substance P in the cardiovascular system},
   volume = {58},
   year = {2016}
}

TY  - JOUR
ID  - 1412145
AU  - Mistrova, Eliska - Kružliak, Peter - Dvorakova Chottova, Magdalena
PY  - 2016
TI  - Role of substance P in the cardiovascular system
JF  - NEUROPEPTIDES
VL  - 58
IS  - AUG 2016
SP  - 41-51
EP  - 41-51
PB  - CHURCHILL LIVINGSTONE
SN  - 01434179
KW  - Substance P
KW  - NK1 receptor
KW  - Cardiovascular regulation
KW  - Antagonist
N2  - This article provides an overview of the structure and function of substance P signalling system and its involvement in the cardiovascular regulation. Substance P is an undecapeptide originating from TAC1 gen and belonging to the tachykinin family. The biological actions of substance P are mainly mediated through neurokinin receptor 1 since substance P is the ligand with the highest affinity to neurokinin receptor 1. Substance P is widely distributed within the central and peripheral nervous systems as well as in the cardiovascular system. Substance P is involved in the regulation of heart frequency, blood pressure and in the stretching of vessels. Substance P plays an important role in ischemia and reperfusion and cardiovascular response to stress. Additionally, it has been also implicated in angiogenesis, pain transmission and inflammation. The substance P/neurokinin receptor 1 receptor system is involved in the molecular bases of many human pathological processes. Antagonists of neurokinin receptor 1 receptor could provide clinical solutions for a variety of diseases. Neurokinin receptor 1 antagonists are already used in the prevention of chemotherapy induced nausea and vomiting. (C) 2015 Elsevier Ltd. All rights reserved.
ER  -

MISTROVA, Eliska; Peter KRUŽLIAK a Magdalena DVORAKOVA CHOTTOVA. Role of substance P in the cardiovascular system. \textit{NEUROPEPTIDES}. EDINBURGH: CHURCHILL LIVINGSTONE, 2016, roč.~58, AUG 2016, s.~41-51. ISSN~0143-4179. Dostupné z: https://doi.org/10.1016/j.npep.2015.12.005.

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