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SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm

DOSTALEK, L., M. ZIKAN, D. FISCHEROVA, R. KOCIAN, A. GERMANOVA, F. FRUHAUF, Ladislav DUŠEK, J. SLAMA, P. DUNDR, K. NEMEJCOVA a D. CIBULA. SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm. Gynecologic Oncology, SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, roč. 148, č. 3, s. 456-460. ISSN 0090-8258. doi:10.1016/j.ygyno.2018.01.001.
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Základní údaje
Originální název SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm
Autoři DOSTALEK, L. (203 Česká republika), M. ZIKAN (203 Česká republika), D. FISCHEROVA (203 Česká republika), R. KOCIAN (203 Česká republika), A. GERMANOVA (203 Česká republika), F. FRUHAUF (203 Česká republika), Ladislav DUŠEK (203 Česká republika, domácí), J. SLAMA (203 Česká republika), P. DUNDR (203 Česká republika), K. NEMEJCOVA (203 Česká republika) a D. CIBULA (203 Česká republika, garant).
Vydání Gynecologic Oncology, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, 0090-8258.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor Obstetrics and gynaecology
Stát vydavatele Spojené státy americké
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 4.540 v roce 2017
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1016/j.ygyno.2018.01.001
UT WoS 000428005300005
Klíčová slova anglicky Cervical cancer; Bulky; Sentinel lymph node; False negative rate; Detection rate; Sensitivity
Štítky 14119612, EL OK, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Soňa Böhmová, učo 232884. Změněno: 10. 2. 2019 19:41.
Anotace
Objectives. The aim of this study was to assess the detection rate, false-negative rate and sensitivity of SLN in LN staging in tumors over 2 cm on a large cohort of patients. Methods. Data from patients with stages pT1a - pT2 cervical cancer who underwent surgical treatment, including SLN biopsy followed by systematic pelvic lymphadenectomy, were retrospectively analyzed. A combined technique with blue dye and radiocolloid was modified in larger tumors to inject the tracer into the residual cervical stroma. Results. The study included 350 patients with stages pTla - pT2. Macrometastases, micrometastases, and isolated tumor cells were found in 10%, 8%, and 4% of cases. Bilateral detection rate was similar in subgroups with tumors < 2 cm, 2-3.9 cm, and >= 4 cm (79%, 83%, 76%) (P = 0.460). There were only two cases with false-negative SLN ultrastaging for pelvic IN status among those with bilateral SLN detection. The false negative rate was very low in all three subgroups of different tumor sizes (0.9%, 0.9%, and 0.0%; P = 0.999). Sensitivity reached 96% in the whole group and was high in all three groups (93%, 93%, 100%; P = 0.510). Conclusions. If the tracer application technique is adjusted in larger tumors, SIN biopsy can be equally reliable in pelvic IN staging in tumors smaller and larger than 2 cm. The bilateral detection rate and false negative rate did not differ in subgroups of patients with tumors < 2 cm, 2-3.9 cm, and cm.
VytisknoutZobrazeno: 23. 4. 2019 08:55

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