SLN biopsy in cervical cancer patients with tumors larger than
2 cm and 4 cm

J 2018

SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm

DOSTALEK, L.; M. ZIKAN; D. FISCHEROVA; R. KOCIAN; A. GERMANOVA et. al.

Základní údaje

Originální název

SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm

Autoři

DOSTALEK, L.; M. ZIKAN; D. FISCHEROVA; R. KOCIAN; A. GERMANOVA; F. FRUHAUF; Ladislav DUŠEK; J. SLAMA; P. DUNDR; K. NEMEJCOVA a D. CIBULA

Vydání

Gynecologic Oncology, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, 0090-8258

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.393

Kód RIV

RIV/00216224:14110/18:00102807

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1016/j.ygyno.2018.01.001

UT WoS

000428005300005

EID Scopus

2-s2.0-85040686409

Klíčová slova anglicky

Cervical cancer; Bulky; Sentinel lymph node; False negative rate; Detection rate; Sensitivity

Štítky

14119612, EL OK, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2019 19:41, Soňa Böhmová

Anotace

V originále

Objectives. The aim of this study was to assess the detection rate, false-negative rate and sensitivity of SLN in LN staging in tumors over 2 cm on a large cohort of patients. Methods. Data from patients with stages pT1a - pT2 cervical cancer who underwent surgical treatment, including SLN biopsy followed by systematic pelvic lymphadenectomy, were retrospectively analyzed. A combined technique with blue dye and radiocolloid was modified in larger tumors to inject the tracer into the residual cervical stroma. Results. The study included 350 patients with stages pTla - pT2. Macrometastases, micrometastases, and isolated tumor cells were found in 10%, 8%, and 4% of cases. Bilateral detection rate was similar in subgroups with tumors < 2 cm, 2-3.9 cm, and >= 4 cm (79%, 83%, 76%) (P = 0.460). There were only two cases with false-negative SLN ultrastaging for pelvic IN status among those with bilateral SLN detection. The false negative rate was very low in all three subgroups of different tumor sizes (0.9%, 0.9%, and 0.0%; P = 0.999). Sensitivity reached 96% in the whole group and was high in all three groups (93%, 93%, 100%; P = 0.510). Conclusions. If the tracer application technique is adjusted in larger tumors, SIN biopsy can be equally reliable in pelvic IN staging in tumors smaller and larger than 2 cm. The bilateral detection rate and false negative rate did not differ in subgroups of patients with tumors < 2 cm, 2-3.9 cm, and cm.

Citovat

DOSTALEK, L.; M. ZIKAN; D. FISCHEROVA; R. KOCIAN; A. GERMANOVA; F. FRUHAUF; Ladislav DUŠEK; J. SLAMA; P. DUNDR; K. NEMEJCOVA a D. CIBULA. SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm. Gynecologic Oncology. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, roč. 148, č. 3, s. 456-460. ISSN 0090-8258. Dostupné z: https://doi.org/10.1016/j.ygyno.2018.01.001.

@article{1418478,
   author = {Dostalek, L. and Zikan, M. and Fischerova, D. and Kocian, R. and Germanova, A. and Fruhauf, F. and Dušek, Ladislav and Slama, J. and Dundr, P. and Nemejcova, K. and Cibula, D.},
   article_location = {SAN DIEGO},
   article_number = {3},
   doi = {https://doi.org/10.1016/j.ygyno.2018.01.001},
   keywords = {Cervical cancer; Bulky; Sentinel lymph node; False negative rate; Detection rate; Sensitivity},
   language = {eng},
   issn = {0090-8258},
   journal = {Gynecologic Oncology},
   title = {SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm},
   volume = {148},
   year = {2018}
}

TY  - JOUR
ID  - 1418478
AU  - Dostalek, L. - Zikan, M. - Fischerova, D. - Kocian, R. - Germanova, A. - Fruhauf, F. - Dušek, Ladislav - Slama, J. - Dundr, P. - Nemejcova, K. - Cibula, D.
PY  - 2018
TI  - SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm
JF  - Gynecologic Oncology
VL  - 148
IS  - 3
SP  - 456-460
EP  - 456-460
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 00908258
KW  - Cervical cancer
KW  - Bulky
KW  - Sentinel lymph node
KW  - False negative rate
KW  - Detection rate
KW  - Sensitivity
N2  - Objectives. The aim of this study was to assess the detection rate, false-negative rate and sensitivity of SLN in LN staging in tumors over 2 cm on a large cohort of patients. Methods. Data from patients with stages pT1a - pT2 cervical cancer who underwent surgical treatment, including SLN biopsy followed by systematic pelvic lymphadenectomy, were retrospectively analyzed. A combined technique with blue dye and radiocolloid was modified in larger tumors to inject the tracer into the residual cervical stroma. Results. The study included 350 patients with stages pTla - pT2. Macrometastases, micrometastases, and isolated tumor cells were found in 10%, 8%, and 4% of cases. Bilateral detection rate was similar in subgroups with tumors < 2 cm, 2-3.9 cm, and >= 4 cm (79%, 83%, 76%) (P = 0.460). There were only two cases with false-negative SLN ultrastaging for pelvic IN status among those with bilateral SLN detection. The false negative rate was very low in all three subgroups of different tumor sizes (0.9%, 0.9%, and 0.0%; P = 0.999). Sensitivity reached 96% in the whole group and was high in all three groups (93%, 93%, 100%; P = 0.510). Conclusions. If the tracer application technique is adjusted in larger tumors, SIN biopsy can be equally reliable in pelvic IN staging in tumors smaller and larger than 2 cm. The bilateral detection rate and false negative rate did not differ in subgroups of patients with tumors < 2 cm, 2-3.9 cm, and cm.
ER  -

DOSTALEK, L.; M. ZIKAN; D. FISCHEROVA; R. KOCIAN; A. GERMANOVA; F. FRUHAUF; Ladislav DUŠEK; J. SLAMA; P. DUNDR; K. NEMEJCOVA a D. CIBULA. SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm. \textit{Gynecologic Oncology}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, roč.~148, č.~3, s.~456-460. ISSN~0090-8258. Dostupné z: https://doi.org/10.1016/j.ygyno.2018.01.001.

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