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@proceedings{1419705,
author = {Vido, Marek and Jarošová, Petra and Táborský, Petr and Peš, Ondřej},
booktitle = {16th Czech - Slovak Spectroscopic Conference},
keywords = {G-quadruplex; electrospray; mass spectrometry; affinity; intramolecular},
language = {eng},
isbn = {978-80-88195-06-1},
title = {INTERACTION OF INTRAMOLECULAR G-QUADRUPLEX DNA STRUCTURES WITH SELECTED ALKALOIDS},
url = {http://16cssc2018.spektroskopie.cz/files/CSSC_2018_BOOK_OF_ABSTRACTS_FINAL.pdf},
year = {2018}
}
TY - CONF
ID - 1419705
AU - Vido, Marek - Jarošová, Petra - Táborský, Petr - Peš, Ondřej
PY - 2018
TI - INTERACTION OF INTRAMOLECULAR G-QUADRUPLEX DNA STRUCTURES WITH SELECTED ALKALOIDS
SN - 9788088195061
KW - G-quadruplex
KW - electrospray
KW - mass spectrometry
KW - affinity
KW - intramolecular
UR - http://16cssc2018.spektroskopie.cz/files/CSSC_2018_BOOK_OF_ABSTRACTS_FINAL.pdf
N2 - G-quadruplex DNA (G4) has been known to be involved in many physiological processes in the cell e.g., in the promoter regions of oncogenes or in the human telomeric region. Because of their supposed role in cancer, G4 are often studied as targets for anti-cancer drugs. Natural and/or synthetic compounds, which are able to selectively bind these structures, have been intensively tested by means of molecular spectrometry, circular dichroism, equilibrium dialysis, and mass spectrometry. Compounds may interact with G4 by several mechanisms with various affinities. An approach to study a great number of potential effective compounds relies on combination of methods when relatively fast; however, imprecise mass spectrometry was used to preselect compounds, which were then subjected to more precise techniques studying G4 in a solution.
ER -
VIDO, Marek, Petra JAROŠOVÁ, Petr TÁBORSKÝ a Ondřej PEŠ. INTERACTION OF INTRAMOLECULAR G-QUADRUPLEX DNA STRUCTURES WITH SELECTED ALKALOIDS. In \textit{16th Czech - Slovak Spectroscopic Conference}. 2018. ISBN~978-80-88195-06-1.
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