White matter measures correlate with essential tremor severity
- a pilot diffusion tensor imaging study

J 2018

White matter measures correlate with essential tremor severity - a pilot diffusion tensor imaging study

NESTRAŠIL, Igor, Alena SVÁTKOVÁ, Rudser KYLE, Ravishankar CHITYALA, Amy WAKAMUTO et. al.

Základní údaje

Originální název

White matter measures correlate with essential tremor severity - a pilot diffusion tensor imaging study

Autoři

NESTRAŠIL, Igor (203 Česká republika), Alena SVÁTKOVÁ (703 Slovensko, domácí), Rudser KYLE (840 Spojené státy), Ravishankar CHITYALA (840 Spojené státy), Amy WAKAMUTO (40 Rakousko), Bryon MUELLER (840 Spojené státy), Petr BEDNAŘÍK (203 Česká republika, garant, domácí), Paule TUITE (840 Spojené státy), Xiang WU (840 Spojené státy) a Khalaf BUSHARA (840 Spojené státy)

Vydání

Brain and Behavior, Hoboken, John Wiley and Sons Inc. 2018, 2162-3279

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.072

Kód RIV

RIV/00216224:14740/18:00102928

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1002/brb3.1039

UT WoS

000449070600014

Klíčová slova anglicky

Essential tremor (ET); Tremor network; diffusion tensor imaging (DTI); TremScore; radial diffusivity; Guillain-Mollaret triangle

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 3. 2019 10:33, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

ABSTRACT Background: An evolving pathophysiological concept of essential tremor (ET) points to diffuse brain network involvement, which emphasizes the need to investigate white matter (WM) changes associated with motor symptoms of ET. Objectives: To investigate ET-related WM changes and WM correlates of tremor severity using tremor clinical rating scales and accelerometry. Methods: Tract-based statistics approach (TBSS) was utilized to compare 3 Tesla diffusion tensor imaging (DTI) data from 12 ET patients and 10 age- and gender-matched healthy individuals. Clinical scales and tremor frequency and amplitude as measured by accelerometry were correlated with DTI data. Results: ET patients demonstrated mean (MD) and radial diffusivity (RD) abnormalities in tracts involved in primary and associative motor functions such as bilateral corticospinal tracts, the superior longitudinal fascicles, and the corpus callosum but also in non-motor regions including the inferior fronto-occipital and longitudinal fascicles, cingulum bundles, anterior thalamic radiations, and uncinate fascicles. A combined tremor frequency and amplitude score correlated with RD and MD in extensive WM areas, which partially overlapped the regions that were associated with tremor frequency. No significant relationship was found between DTI measures and clinical rating scales scores. Conclusions: The results show that ET-related diffusion WM changes and their correlates with tremor severity are preferentially located in the primary and associative motor areas. In contrast, a relationship between WM was not detected with clinical rating scales. Accelerometry parameters may, therefore, serve as a potentially useful clinical measures that relate to WM deficits in ET.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

NESTRAŠIL, Igor, Alena SVÁTKOVÁ, Rudser KYLE, Ravishankar CHITYALA, Amy WAKAMUTO, Bryon MUELLER, Petr BEDNAŘÍK, Paule TUITE, Xiang WU a Khalaf BUSHARA. White matter measures correlate with essential tremor severity - a pilot diffusion tensor imaging study. Brain and Behavior. Hoboken: John Wiley and Sons Inc., 2018, roč. 8, č. 8, s. 1-11. ISSN 2162-3279. Dostupné z: https://dx.doi.org/10.1002/brb3.1039.

@article{1419797,
   author = {Nestrašil, Igor and Svátková, Alena and Kyle, Rudser and Chityala, Ravishankar and Wakamuto, Amy and Mueller, Bryon and Bednařík, Petr and Tuite, Paule and Wu, Xiang and Bushara, Khalaf},
   article_location = {Hoboken},
   article_number = {8},
   doi = {http://dx.doi.org/10.1002/brb3.1039},
   keywords = {Essential tremor (ET); Tremor network; diffusion tensor imaging (DTI); TremScore; radial diffusivity; Guillain-Mollaret triangle},
   language = {eng},
   issn = {2162-3279},
   journal = {Brain and Behavior},
   title = {White matter measures correlate with essential tremor severity - a pilot diffusion tensor imaging study},
   url = {https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.1039},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1419797
AU  - Nestrašil, Igor - Svátková, Alena - Kyle, Rudser - Chityala, Ravishankar - Wakamuto, Amy - Mueller, Bryon - Bednařík, Petr - Tuite, Paule - Wu, Xiang - Bushara, Khalaf
PY  - 2018
TI  - White matter measures correlate with essential tremor severity - a pilot diffusion tensor imaging study
JF  - Brain and Behavior
VL  - 8
IS  - 8
SP  - 1-11
EP  - 1-11
PB  - John Wiley and Sons Inc.
SN  - 21623279
KW  - Essential tremor (ET)
KW  - Tremor network
KW  - diffusion tensor imaging (DTI)
KW  - TremScore
KW  - radial diffusivity
KW  - Guillain-Mollaret triangle
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.1039
N2  - ABSTRACT Background: An evolving pathophysiological concept of essential tremor (ET) points to diffuse brain network involvement, which emphasizes the need to investigate white matter (WM) changes associated with motor symptoms of ET. Objectives: To investigate ET-related WM changes and WM correlates of tremor severity using tremor clinical rating scales and accelerometry. Methods: Tract-based statistics approach (TBSS) was utilized to compare 3 Tesla diffusion tensor imaging (DTI) data from 12 ET patients and 10 age- and gender-matched healthy individuals. Clinical scales and tremor frequency and amplitude as measured by accelerometry were correlated with DTI data. Results: ET patients demonstrated mean (MD) and radial diffusivity (RD) abnormalities in tracts involved in primary and associative motor functions such as bilateral corticospinal tracts, the superior longitudinal fascicles, and the corpus callosum but also in non-motor regions including the inferior fronto-occipital and longitudinal fascicles, cingulum bundles, anterior thalamic radiations, and uncinate fascicles. A combined tremor frequency and amplitude score correlated with RD and MD in extensive WM areas, which partially overlapped the regions that were associated with tremor frequency. No significant relationship was found between DTI measures and clinical rating scales scores. Conclusions: The results show that ET-related diffusion WM changes and their correlates with tremor severity are preferentially located in the primary and associative motor areas. In contrast, a relationship between WM was not detected with clinical rating scales. Accelerometry parameters may, therefore, serve as a potentially useful clinical measures that relate to WM deficits in ET.
ER  -

NESTRAŠIL, Igor, Alena SVÁTKOVÁ, Rudser KYLE, Ravishankar CHITYALA, Amy WAKAMUTO, Bryon MUELLER, Petr BEDNAŘÍK, Paule TUITE, Xiang WU a Khalaf BUSHARA. White matter measures correlate with essential tremor severity - a pilot diffusion tensor imaging study. \textit{Brain and Behavior}. Hoboken: John Wiley and Sons Inc., 2018, roč.~8, č.~8, s.~1-11. ISSN~2162-3279. Dostupné z: https://dx.doi.org/10.1002/brb3.1039.

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