Global prevalence, treatment, and prevention of hepatitis B
virus infection in 2016: a modelling study

J 2018

Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study

RAZAVI-SHEARER, Devin, Ivane GAMKRELIDZE, Mindie H. NGUYEN, Ding-Shinn CHEN, Petr HUSA et. al.

Základní údaje

Originální název

Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study

Autoři

RAZAVI-SHEARER, Devin (840 Spojené státy, garant), Ivane GAMKRELIDZE (840 Spojené státy), Mindie H. NGUYEN (840 Spojené státy), Ding-Shinn CHEN (158 Tchaj-wan) a Petr HUSA (203 Česká republika, domácí)

Vydání

LANCET GASTROENTEROLOGY & HEPATOLOGY, SAN DIEGO, ELSEVIER INC, 2018, 2468-1253

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 12.856

Kód RIV

RIV/00216224:14110/18:00103213

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/S2468-1253(18)30056-6

UT WoS

000436553600019

Klíčová slova anglicky

hepatitis B antibody; hepatitis B surface antigen; hepatitis B vaccine

Štítky

14110214, EL OK, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 3. 2019 15:12, Soňa Böhmová

Anotace

V originále

Background The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate viral hepatitis by 2030. Although no virological cure exists for hepatitis B virus (HBV) infection, existing therapies to control viral replication and prophylaxis to minimise mother-to-child transmission make elimination of HBV feasible. We aimed to estimate the national, regional, and global prevalence of HBsAg in the general population and in the population aged 5 years in 2016, as well as coverage of prophylaxis, diagnosis, and treatment. Methods In this modelling study, we used a Delphi process that included a literature review in PubMed and Embase, followed by interviews with experts, to quantify the historical epidemiology of HBV infection. We then used a dynamic HBV transmission and progression model to estimate the country-level and regional-level prevalence of HBsAg in 2016 and the effect of prophylaxis and treatment on disease burden. Findings We developed models for 120 countries, 78 of which were populated with data approved by experts. Using these models, we estimated that the global prevalence of HBsAg in 2016 was 3.9% (95% uncertainty interval [UI] 3.4-4.6), corresponding to 291 992 000 (251 513 000-341 114 000) infections. Of these infections, around 29 million (10%) were diagnosed, and only 4.8 million (5%) of 94 million individuals eligible for treatment actually received antiviral therapy. Around 1.8 (1.6-2.2) million infections were in children aged 5 years, with a prevalence of 1.4% (1.2-1.6). We estimated that 87% of infants had received the three-dose HBV vaccination in the first year of life, 46% had received timely birth-dose vaccination, and 13% had received hepatitis B immunoglobulin along with the full vaccination regimen. Less than 1% of mothers with a high viral load had received antiviral therapy to reduce mother-to-child transmission. Interpretation Our estimate of HBV prevalence in 2016 differs from previous studies, potentially because we took into account the effect of infant prophylaxis and early childhood vaccination, as well as changing prevalence over time. Although some regions are well on their way to meeting prophylaxis and prevalence targets, all regions must substantially scale-up access to diagnosis and treatment to meet the global targets. Funding John C Martin Foundation. Copyright (c) 2018 Elsevier Ltd. All rights reserved.

Citovat

RAZAVI-SHEARER, Devin, Ivane GAMKRELIDZE, Mindie H. NGUYEN, Ding-Shinn CHEN a Petr HUSA. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. LANCET GASTROENTEROLOGY & HEPATOLOGY. SAN DIEGO: ELSEVIER INC, 2018, roč. 3, č. 6, s. 383-403. ISSN 2468-1253. Dostupné z: https://dx.doi.org/10.1016/S2468-1253(18)30056-6.

@article{1423204,
   author = {RazaviandShearer, Devin and Gamkrelidze, Ivane and Nguyen, Mindie H. and Chen, DingandShinn and Husa, Petr},
   article_location = {SAN DIEGO},
   article_number = {6},
   doi = {http://dx.doi.org/10.1016/S2468-1253(18)30056-6},
   keywords = {hepatitis B antibody; hepatitis B surface antigen; hepatitis B vaccine},
   language = {eng},
   issn = {2468-1253},
   journal = {LANCET GASTROENTEROLOGY & HEPATOLOGY},
   title = {Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study},
   volume = {3},
   year = {2018}
}

TY  - JOUR
ID  - 1423204
AU  - Razavi-Shearer, Devin - Gamkrelidze, Ivane - Nguyen, Mindie H. - Chen, Ding-Shinn - Husa, Petr
PY  - 2018
TI  - Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study
JF  - LANCET GASTROENTEROLOGY & HEPATOLOGY
VL  - 3
IS  - 6
SP  - 383-403
EP  - 383-403
PB  - ELSEVIER INC
SN  - 24681253
KW  - hepatitis B antibody
KW  - hepatitis B surface antigen
KW  - hepatitis B vaccine
N2  - Background The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate viral hepatitis by 2030. Although no virological cure exists for hepatitis B virus (HBV) infection, existing therapies to control viral replication and prophylaxis to minimise mother-to-child transmission make elimination of HBV feasible. We aimed to estimate the national, regional, and global prevalence of HBsAg in the general population and in the population aged 5 years in 2016, as well as coverage of prophylaxis, diagnosis, and treatment. Methods In this modelling study, we used a Delphi process that included a literature review in PubMed and Embase, followed by interviews with experts, to quantify the historical epidemiology of HBV infection. We then used a dynamic HBV transmission and progression model to estimate the country-level and regional-level prevalence of HBsAg in 2016 and the effect of prophylaxis and treatment on disease burden. Findings We developed models for 120 countries, 78 of which were populated with data approved by experts. Using these models, we estimated that the global prevalence of HBsAg in 2016 was 3.9% (95% uncertainty interval [UI] 3.4-4.6), corresponding to 291 992 000 (251 513 000-341 114 000) infections. Of these infections, around 29 million (10%) were diagnosed, and only 4.8 million (5%) of 94 million individuals eligible for treatment actually received antiviral therapy. Around 1.8 (1.6-2.2) million infections were in children aged 5 years, with a prevalence of 1.4% (1.2-1.6). We estimated that 87% of infants had received the three-dose HBV vaccination in the first year of life, 46% had received timely birth-dose vaccination, and 13% had received hepatitis B immunoglobulin along with the full vaccination regimen. Less than 1% of mothers with a high viral load had received antiviral therapy to reduce mother-to-child transmission. Interpretation Our estimate of HBV prevalence in 2016 differs from previous studies, potentially because we took into account the effect of infant prophylaxis and early childhood vaccination, as well as changing prevalence over time. Although some regions are well on their way to meeting prophylaxis and prevalence targets, all regions must substantially scale-up access to diagnosis and treatment to meet the global targets. Funding John C Martin Foundation. Copyright (c) 2018 Elsevier Ltd. All rights reserved.
ER  -

RAZAVI-SHEARER, Devin, Ivane GAMKRELIDZE, Mindie H. NGUYEN, Ding-Shinn CHEN a Petr HUSA. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. \textit{LANCET GASTROENTEROLOGY \&{}amp; HEPATOLOGY}. SAN DIEGO: ELSEVIER INC, 2018, roč.~3, č.~6, s.~383-403. ISSN~2468-1253. Dostupné z: https://dx.doi.org/10.1016/S2468-1253(18)30056-6.

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