Respiratory parameters predict poor outcome in COPD patients,
category GOLD 2017 B

J 2018

Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B

BRAT, Kristián; Marek PLUTINSKÝ; Karel HEJDUK; Michal SVOBODA; Patrice POPELKOVA et. al.

Základní údaje

Originální název

Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B

Autoři

BRAT, Kristián; Marek PLUTINSKÝ; Karel HEJDUK; Michal SVOBODA; Patrice POPELKOVA; Jaromir ZATLOUKAL; Eva VOLAKOVA; Miroslava PECANINOVA; Lucie HERIBANOVA a Vladimir KOBLIZEK

Vydání

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Auckland, Dove Medical Press Ltd. 2018, 1178-2005

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30203 Respiratory systems

Stát vydavatele

Nový Zéland

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.274

Kód RIV

RIV/00216224:14110/18:00103237

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.2147/COPD.S147262

UT WoS

000428799800002

EID Scopus

2-s2.0-85044778267

Klíčová slova anglicky

COPD; GOLD 2017 update; Hypercapnia; Hypoxemia; Mortality

Štítky

14110215, 14119612, EL OK, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 5. 2019 13:31, Soňa Böhmová

Anotace

V originále

Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients. Kaplan–Meier survival analyses were performed at different levels of respiratory parameters (partial pressure of oxygen in arterial blood [PaO2], partial pressure of arterial carbon dioxide [PaCO2] and greatest decrease of basal peripheral capillary oxygen saturation during 6-minute walking test [6-MWT]). Univariate analyses using the Cox proportional hazard model and multivariate analyses were used to identify risk factors for mortality in hypoxemic and hypercapnic individuals with COPD. Results: All-cause mortality in the cohort at 3 years of prospective follow-up reached 18.4%. Chronic hypoxemia (PaO2<7.3 kPa), hypercapnia (PaCO2>7.0 kPa) and oxygen desaturation during the 6-MWT were predictors of long-term mortality in COPD patients with forced expiratory volume in 1 second #60% for the overall cohort and for GOLD B category patients. Univariate analyses confirmed the association among decreased oxemia (<7.3 kPa), increased capnemia (>7.0 kPa), oxygen desaturation during 6-MWT and mortality in the studied groups of COPD subjects. Multivariate analysis identified PaO2<7.3 kPa as a strong independent risk factor for mortality. Conclusion: Survival analyses showed significantly increased all-cause mortality in hypoxemic and hypercapnic GOLD B subjects. More important, PaO2<7.3 kPa was the strongest risk factor, especially in category B patients. In contrast, the majority of the tested respiratory parameters did not show a difference in mortality in the GOLD category D cohort.

Citovat

BRAT, Kristián; Marek PLUTINSKÝ; Karel HEJDUK; Michal SVOBODA; Patrice POPELKOVA; Jaromir ZATLOUKAL; Eva VOLAKOVA; Miroslava PECANINOVA; Lucie HERIBANOVA a Vladimir KOBLIZEK. Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Auckland: Dove Medical Press Ltd., 2018, roč. 13, č. 2018, s. 1037-1052. ISSN 1178-2005. Dostupné z: https://doi.org/10.2147/COPD.S147262.

@article{1423307,
   author = {Brat, Kristián and Plutinský, Marek and Hejduk, Karel and Svoboda, Michal and Popelkova, Patrice and Zatloukal, Jaromir and Volakova, Eva and Pecaninova, Miroslava and Heribanova, Lucie and Koblizek, Vladimir},
   article_location = {Auckland},
   article_number = {2018},
   doi = {https://doi.org/10.2147/COPD.S147262},
   keywords = {COPD; GOLD 2017 update; Hypercapnia; Hypoxemia; Mortality},
   language = {eng},
   issn = {1178-2005},
   journal = {INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE},
   title = {Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B},
   volume = {13},
   year = {2018}
}

TY  - JOUR
ID  - 1423307
AU  - Brat, Kristián - Plutinský, Marek - Hejduk, Karel - Svoboda, Michal - Popelkova, Patrice - Zatloukal, Jaromir - Volakova, Eva - Pecaninova, Miroslava - Heribanova, Lucie - Koblizek, Vladimir
PY  - 2018
TI  - Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B
JF  - INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
VL  - 13
IS  - 2018
SP  - 1037-1052
EP  - 1037-1052
PB  - Dove Medical Press Ltd.
SN  - 11782005
KW  - COPD
KW  - GOLD 2017 update
KW  - Hypercapnia
KW  - Hypoxemia
KW  - Mortality
N2  - Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted in a vertical shift of patients across COPD categories, with category B being the most populous and clinically heterogeneous. The aim of our study was to investigate whether respiratory parameters might be associated with increased all-cause mortality within GOLD category B patients. Methods: The data were extracted from the Czech Multicentre Research Database, a prospective, noninterventional multicenter study of COPD patients. Kaplan–Meier survival analyses were performed at different levels of respiratory parameters (partial pressure of oxygen in arterial blood [PaO2], partial pressure of arterial carbon dioxide [PaCO2] and greatest decrease of basal peripheral capillary oxygen saturation during 6-minute walking test [6-MWT]). Univariate analyses using the Cox proportional hazard model and multivariate analyses were used to identify risk factors for mortality in hypoxemic and hypercapnic individuals with COPD. Results: All-cause mortality in the cohort at 3 years of prospective follow-up reached 18.4%. Chronic hypoxemia (PaO2<7.3 kPa), hypercapnia (PaCO2>7.0 kPa) and oxygen desaturation during the 6-MWT were predictors of long-term mortality in COPD patients with forced expiratory volume in 1 second #60% for the overall cohort and for GOLD B category patients. Univariate analyses confirmed the association among decreased oxemia (<7.3 kPa), increased capnemia (>7.0 kPa), oxygen desaturation during 6-MWT and mortality in the studied groups of COPD subjects. Multivariate analysis identified PaO2<7.3 kPa as a strong independent risk factor for mortality. Conclusion: Survival analyses showed significantly increased all-cause mortality in hypoxemic and hypercapnic GOLD B subjects. More important, PaO2<7.3 kPa was the strongest risk factor, especially in category B patients. In contrast, the majority of the tested respiratory parameters did not show a difference in mortality in the GOLD category D cohort.
ER  -

BRAT, Kristián; Marek PLUTINSKÝ; Karel HEJDUK; Michal SVOBODA; Patrice POPELKOVA; Jaromir ZATLOUKAL; Eva VOLAKOVA; Miroslava PECANINOVA; Lucie HERIBANOVA a Vladimir KOBLIZEK. Respiratory parameters predict poor outcome in COPD patients, category GOLD 2017 B. \textit{INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE}. Auckland: Dove Medical Press Ltd., 2018, roč.~13, č.~2018, s.~1037-1052. ISSN~1178-2005. Dostupné z: https://doi.org/10.2147/COPD.S147262.

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