ROVNY, Rastislav, Martin MARKO, Stanislav KATINA, Jana MURINOVA, Veronika ROHARIKOVA, Barbora CIMROVA, Gabriela REPISKA, Gabriel MINARIK a Igor RIECANSKY. Association between genetic variability of neuronal nitric oxide synthase T and sensorimotor gating in humans. Nitric Oxide, Rochester, USA: Elsevier, 2018, roč. 80, č. 1, s. 32-36. ISSN 1089-8603. doi:10.1016/j.niox.2018.08.002.
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Základní údaje
Originální název Association between genetic variability of neuronal nitric oxide synthase T and sensorimotor gating in humans
Autoři ROVNY, Rastislav (703 Slovensko), Martin MARKO (703 Slovensko), Stanislav KATINA (703 Slovensko, domácí), Jana MURINOVA (703 Slovensko), Veronika ROHARIKOVA (703 Slovensko), Barbora CIMROVA (703 Slovensko), Gabriela REPISKA (703 Slovensko), Gabriel MINARIK (703 Slovensko) a Igor RIECANSKY (703 Slovensko, garant).
Vydání Nitric Oxide, Rochester, USA, Elsevier, 2018, 1089-8603.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor Statistics and probability
Stát vydavatele Spojené státy americké
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 3.371
Kód RIV RIV/00216224:14310/18:00103407
Organizační jednotka Přírodovědecká fakulta
Doi http://dx.doi.org/10.1016/j.niox.2018.08.002
Klíčová slova anglicky Nitric oxide; NOS1; Schizophrenia; Prepulse inhibition; Startle; Endophenotypes
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnil: doc. PaedDr. RNDr. Stanislav Katina, Ph.D., učo 111465. Změněno: 12. 8. 2018 13:10.
Anotace
Research increasingly suggests that nitric oxide (NO) plays a role in the pathogenesis of schizophrenia. One important line of evidence comes from genetic studies, which have repeatedly detected an association between the neuronal isoform of nitric oxide synthase (nNOS or NOS1) and schizophrenia. However, the pathogenetic pathways linking nNOS, NO, and the disorder remain poorly understood. A deficit in sensorimotor gating is considered to importantly contribute to core schizophrenia symptoms such as psychotic disorganization and thought disturbance. We selected three candidate nNOS polymorphisms (Ex1f-VNTR, rs6490121 and rs41279104), associated with schizophrenia and cognition in previous studies, and tested their association with the efficiency of sensorimotor gating in healthy human adults. We found that risk variants of Ex1f-VNTR and rs6490121 (but not rs41279104) were associated with a weaker prepulse inhibition (PPI) of the acoustic startle reflex, a standard measure of sensorimotor gating. Furthermore, the effect of presence of risk variants in Ex1f- VNTR and rs6490121 was additive: PPI linearly decreased with increasing number of risk alleles, being highest in participants with no risk allele, while lowest in individuals who carry three risk alleles. Our findings indicate that NO is involved in the regulation of sensorimotor gating, and highlight one possible pathogenetic mechanism for NO playing a role in the development of schizophrenia psychosis.
VytisknoutZobrazeno: 18. 9. 2019 15:57