| SUPEKAR, S., Anna PAPAGEORGIOU, G. GEMMECKER, R. PELTZER, M.P. JOHANSSON, Konstantinos TRIPSIANES, M. SATTLER a V.R.I. KAILA. Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain. Angewandte Chemie International Edition. WEINHEIM (GERMANY): Verlag Chemie, 2018, roč. 57, č. 2, s. 486-490. ISSN 1433-7851. Dostupné z: https://dx.doi.org/10.1002/anie.201708233. |
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@article{1430704,
author = {Supekar, S. and Papageorgiou, Anna and Gemmecker, G. and Peltzer, R. and Johansson, M.P. and Tripsianes, Konstantinos and Sattler, M. and Kaila, V.R.I.},
article_location = {WEINHEIM (GERMANY)},
article_number = {2},
doi = {http://dx.doi.org/10.1002/anie.201708233},
keywords = {arginine rotation; cation-p interactions; dynamic NMR; QM/MM; quantum chemistry},
language = {eng},
issn = {1433-7851},
journal = {Angewandte Chemie International Edition},
title = {Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain},
volume = {57},
year = {2018}
}
TY - JOUR
ID - 1430704
AU - Supekar, S. - Papageorgiou, Anna - Gemmecker, G. - Peltzer, R. - Johansson, M.P. - Tripsianes, Konstantinos - Sattler, M. - Kaila, V.R.I.
PY - 2018
TI - Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain
JF - Angewandte Chemie International Edition
VL - 57
IS - 2
SP - 486-490
EP - 486-490
PB - Verlag Chemie
SN - 14337851
KW - arginine rotation
KW - cation-p interactions
KW - dynamic NMR
KW - QM/MM
KW - quantum chemistry
N2 - Tudor domains bind to dimethylarginine (DMA) residues, which are post-translational modifications that play a central role in gene regulation in eukaryotic cells. NMR spectroscopy and quantum calculations are combined to demonstrate that DMA recognition by Tudor domains involves conformational selection. The binding mechanism is confirmed by a mutation in the aromatic cage that perturbs the native recognition mode of the ligand. General mechanistic principles are delineated from the combined results, indicating that Tudor domains utilize cation-p interactions to achieve ligand recognition.
ER -
SUPEKAR, S., Anna PAPAGEORGIOU, G. GEMMECKER, R. PELTZER, M.P. JOHANSSON, Konstantinos TRIPSIANES, M. SATTLER a V.R.I. KAILA. Conformational Selection of Dimethylarginine Recognition by the Survival Motor Neuron Tudor Domain. \textit{Angewandte Chemie International Edition}. WEINHEIM (GERMANY): Verlag Chemie, 2018, roč.~57, č.~2, s.~486-490. ISSN~1433-7851. Dostupné z: https://dx.doi.org/10.1002/anie.201708233.
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