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@article{1433356,
author = {Marcián, Václav and Mareček, Radek and Koriťáková, Eva and Pail, Martin and Bareš, Martin and Brázdil, Milan},
article_location = {London},
article_number = {JAN 2018},
doi = {http://dx.doi.org/10.1016/j.seizure.2017.12.004},
keywords = {Epilepsy surgery outcome; AAL atlas; Clinical correlations},
language = {eng},
issn = {1059-1311},
journal = {SEIZURE-EUROPEAN JOURNAL OF EPILEPSY},
title = {Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy},
volume = {54},
year = {2018}
}
TY - JOUR
ID - 1433356
AU - Marcián, Václav - Mareček, Radek - Koriťáková, Eva - Pail, Martin - Bareš, Martin - Brázdil, Milan
PY - 2018
TI - Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy
JF - SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
VL - 54
IS - JAN 2018
SP - 51-57
EP - 51-57
PB - W B SAUNDERS CO LTD
SN - 10591311
KW - Epilepsy surgery outcome
KW - AAL atlas
KW - Clinical correlations
N2 - Purpose: To evaluate cerebellar volume changes in temporal lobe epilepsy (TLE) patients in greater detail. We aimed to determine which discrete substructures significantly differ in patients with TLE compared to controls and the nature of this difference. Correlations with age at epilepsy onset, epilepsy duration, seizure frequency, and total number of antiepileptic drugs (AED) in the patient's history were studied. We analyzed the potential association between cerebellar atrophy and epilepsy surgery outcome. Methods: Study participants were 36 TLE patients; 22 hippocampal sclerosis (HS) only and 38 healthy controls. All patients later underwent temporal lobe resection. All subjects were examined using 1.5T MRI. Cerebellar volume was adjusted for total intracranial volume, age, and gender, and measured using voxel-based morphometry. Cerebellar substructures were defined using the AAL atlas. Data processing was performed automatically. Separate analyses for HS only subset were performed. Results: Total cerebellar gray matter volume (GMV) appeared non-significantly smaller in epilepsy patients. Within the substructures, the GMV of the selected vermian segments were significantly larger in patients. The GMV of the whole cerebellum and of all individual cerebellar substructures non significantly decreased with increasing complex partial seizure frequency and total number of AEDs in the patient's history. Total cerebellar GMV was significantly smaller in patients with persistent seizures after epilepsy surgery than in seizure-free patients. Conclusion: Cerebellar atrophy is a complex phenomenon, the character of changes differs significantly within the cerebellar substructures. Total cerebellar GMV reduction is associated with worse outcome of temporal lobe resection.
ER -
MARCIÁN, Václav, Radek MAREČEK, Eva KORIŤÁKOVÁ, Martin PAIL, Martin BAREŠ a Milan BRÁZDIL. Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy. \textit{SEIZURE-EUROPEAN JOURNAL OF EPILEPSY}. London: W B SAUNDERS CO LTD, 2018, roč.~54, JAN 2018, s.~51-57. ISSN~1059-1311. Dostupné z: https://dx.doi.org/10.1016/j.seizure.2017.12.004.
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