hIAPP forms toxic oligomers in plasma

J 2018

hIAPP forms toxic oligomers in plasma

CAMARGO, D.C.R.; D. GARG; K. BUDAY; A. FRANKO; A.R. CAMARGO et al.

Základní údaje

Originální název

hIAPP forms toxic oligomers in plasma

Autoři

Vydání

Chemical communications, Cambridge, Royal Society of Chemistry, 2018, 1359-7345

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10400 1.4 Chemical sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 6.164

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/18:00103642

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

ISLET AMYLOID POLYPEPTIDE; INTRINSIC FLUORESCENCE; DIABETES-MELLITUS; TRANSGENIC MICE; INSULIN; AMYLIN; BETA; AGGREGATION; MECHANISM; FIBRILS

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2019 13:25, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in -sheet rich oligomers with increased -cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

CAMARGO, D.C.R.; D. GARG; K. BUDAY; A. FRANKO; A.R. CAMARGO; F. SCHMIDT; S.J. COX; S. SULADZE; M. HASLBECK; Y.G. MIDEKSA; G. GEMMECKER; M. AICHLER; G. METTENLEITER; M. SCHULZ; A.K. WALCH; M.H. DE ANGELIS; M.J. FEIGE; C.A. SIERRA; M. CONRAD; Konstantinos TRIPSIANES; A. RAMAMOORTHY a B. REIF. hIAPP forms toxic oligomers in plasma. Chemical communications. Cambridge: Royal Society of Chemistry, 2018, roč. 54, č. 43, s. 5426-5429. ISSN 1359-7345. Dostupné z: https://doi.org/10.1039/c8cc03097a.

@article{1435120,
   author = {Camargo, D.C.R. and Garg, D. and Buday, K. and Franko, A. and Camargo, A.R. and Schmidt, F. and Cox, S.J. and Suladze, S. and Haslbeck, M. and Mideksa, Y.G. and Gemmecker, G. and Aichler, M. and Mettenleiter, G. and Schulz, M. and Walch, A.K. and de Angelis, M.H. and Feige, M.J. and Sierra, C.A. and Conrad, M. and Tripsianes, Konstantinos and Ramamoorthy, A. and Reif, B.},
   article_location = {Cambridge},
   article_number = {43},
   doi = {https://doi.org/10.1039/c8cc03097a},
   keywords = {ISLET AMYLOID POLYPEPTIDE; INTRINSIC FLUORESCENCE; DIABETES-MELLITUS; TRANSGENIC MICE; INSULIN; AMYLIN; BETA; AGGREGATION; MECHANISM; FIBRILS},
   language = {eng},
   issn = {1359-7345},
   journal = {Chemical communications},
   title = {hIAPP forms toxic oligomers in plasma},
   volume = {54},
   year = {2018}
}

TY  - JOUR
ID  - 1435120
AU  - Camargo, D.C.R. - Garg, D. - Buday, K. - Franko, A. - Camargo, A.R. - Schmidt, F. - Cox, S.J. - Suladze, S. - Haslbeck, M. - Mideksa, Y.G. - Gemmecker, G. - Aichler, M. - Mettenleiter, G. - Schulz, M. - Walch, A.K. - de Angelis, M.H. - Feige, M.J. - Sierra, C.A. - Conrad, M. - Tripsianes, Konstantinos - Ramamoorthy, A. - Reif, B.
PY  - 2018
TI  - hIAPP forms toxic oligomers in plasma
JF  - Chemical communications
VL  - 54
IS  - 43
SP  - 5426-5429
EP  - 5426-5429
PB  - Royal Society of Chemistry
SN  - 13597345
KW  - ISLET AMYLOID POLYPEPTIDE
KW  - INTRINSIC FLUORESCENCE
KW  - DIABETES-MELLITUS
KW  - TRANSGENIC MICE
KW  - INSULIN
KW  - AMYLIN
KW  - BETA
KW  - AGGREGATION
KW  - MECHANISM
KW  - FIBRILS
N2  - In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in -sheet rich oligomers with increased -cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.
ER  -

CAMARGO, D.C.R.; D. GARG; K. BUDAY; A. FRANKO; A.R. CAMARGO; F. SCHMIDT; S.J. COX; S. SULADZE; M. HASLBECK; Y.G. MIDEKSA; G. GEMMECKER; M. AICHLER; G. METTENLEITER; M. SCHULZ; A.K. WALCH; M.H. DE ANGELIS; M.J. FEIGE; C.A. SIERRA; M. CONRAD; Konstantinos TRIPSIANES; A. RAMAMOORTHY a B. REIF. hIAPP forms toxic oligomers in plasma. \textit{Chemical communications}. Cambridge: Royal Society of Chemistry, 2018, roč.~54, č.~43, s.~5426-5429. ISSN~1359-7345. Dostupné z: https://doi.org/10.1039/c8cc03097a.

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