RUDÁ, Jana, Petra AMCHOVÁ, Alena MÁCHALOVÁ, Jana PISTOVČÁKOVÁ a Alexandra ŠULCOVÁ. PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE. Psychiatria danubina. Zagreb: Medicinska naklada Zagreb, 2018, roč. 30, č. 3, s. 356-366. ISSN 0353-5053. Dostupné z: https://dx.doi.org/10.24869/psyd.2018.356. |
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@article{1443237, author = {Rudá, Jana and Amchová, Petra and Máchalová, Alena and Pistovčáková, Jana and Šulcová, Alexandra}, article_location = {Zagreb}, article_number = {3}, doi = {http://dx.doi.org/10.24869/psyd.2018.356}, keywords = {modafinil; prenatal administration; locomotion; phagocytosis; mice}, language = {eng}, issn = {0353-5053}, journal = {Psychiatria danubina}, title = {PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE}, volume = {30}, year = {2018} }
TY - JOUR ID - 1443237 AU - Rudá, Jana - Amchová, Petra - Máchalová, Alena - Pistovčáková, Jana - Šulcová, Alexandra PY - 2018 TI - PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE JF - Psychiatria danubina VL - 30 IS - 3 SP - 356-366 EP - 356-366 PB - Medicinska naklada Zagreb SN - 03535053 KW - modafinil KW - prenatal administration KW - locomotion KW - phagocytosis KW - mice N2 - Background: Modafinil is a psychostimulant drug prescribed mainly for treatment of narcolepsy but is used as a "smart drug" by wide populations to increase wakefulness, concentration and overall mental performance. The aim of this study was to assess potential developmental toxicity of modafinil. Materials and methods: Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestational day (GD) 3 to GD 10 and then a challenge dose on the GD 17. The male offspring were treated analogously at the age of 10 weeks. Changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open-field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-day wash-out period. One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. Results: The most important finding of this study was the immunosuppressing effect on leukocyte activity, hypolocomotion and increased behavioural response to modafinil-induced psychostimulation caused by prenatal exposure to the same drug. We did not detect significantly altered anxiety-related behaviour in any group disregarding the pre- and postnatal treatments. Conclusion: This is the first evidence of developmental toxicity of modafinil which needs to be taken into account as a potential risk factor when modafinil is administered to women who may become or are pregnant. ER -
RUDÁ, Jana, Petra AMCHOVÁ, Alena MÁCHALOVÁ, Jana PISTOVČÁKOVÁ a Alexandra ŠULCOVÁ. PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE. \textit{Psychiatria danubina}. Zagreb: Medicinska naklada Zagreb, 2018, roč.~30, č.~3, s.~356-366. ISSN~0353-5053. Dostupné z: https://dx.doi.org/10.24869/psyd.2018.356.
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