PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND
LEUCOCYTE PHAGOCYTOSIS IN MICE

J 2018

PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE

RUDÁ, Jana; Petra AMCHOVÁ; Alena MÁCHALOVÁ; Jana PISTOVČÁKOVÁ; Alexandra ŠULCOVÁ et. al.

Základní údaje

Originální název

PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE

Název česky

Prenatální expozice modafinilu ovlivňuje lokomoci a leukocytární fagocytózu u myších samců

Autoři

RUDÁ, Jana; Petra AMCHOVÁ; Alena MÁCHALOVÁ ; Jana PISTOVČÁKOVÁ a Alexandra ŠULCOVÁ

Vydání

Psychiatria danubina, Zagreb, Medicinska naklada Zagreb, 2018, 0353-5053

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Chorvatsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.683

Kód RIV

RIV/00216224:14110/18:00103872

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.24869/psyd.2018.356

UT WoS

000445798700014

EID Scopus

2-s2.0-85054721634

Klíčová slova anglicky

modafinil; prenatal administration; locomotion; phagocytosis; mice

Štítky

14110516, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 3. 2019 10:45, Soňa Böhmová

Anotace

V originále

Background: Modafinil is a psychostimulant drug prescribed mainly for treatment of narcolepsy but is used as a "smart drug" by wide populations to increase wakefulness, concentration and overall mental performance. The aim of this study was to assess potential developmental toxicity of modafinil. Materials and methods: Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestational day (GD) 3 to GD 10 and then a challenge dose on the GD 17. The male offspring were treated analogously at the age of 10 weeks. Changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open-field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-day wash-out period. One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. Results: The most important finding of this study was the immunosuppressing effect on leukocyte activity, hypolocomotion and increased behavioural response to modafinil-induced psychostimulation caused by prenatal exposure to the same drug. We did not detect significantly altered anxiety-related behaviour in any group disregarding the pre- and postnatal treatments. Conclusion: This is the first evidence of developmental toxicity of modafinil which needs to be taken into account as a potential risk factor when modafinil is administered to women who may become or are pregnant.

Návaznosti

MUNI/A/1132/2017, interní kód MU

Název: Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv

Investor: Masarykova univerzita, Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

RUDÁ, Jana; Petra AMCHOVÁ; Alena MÁCHALOVÁ; Jana PISTOVČÁKOVÁ a Alexandra ŠULCOVÁ. PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE. Psychiatria danubina. Zagreb: Medicinska naklada Zagreb, 2018, roč. 30, č. 3, s. 356-366. ISSN 0353-5053. Dostupné z: https://doi.org/10.24869/psyd.2018.356.

@article{1443237,
   author = {Rudá, Jana and Amchová, Petra and Máchalová, Alena and Pistovčáková, Jana and Šulcová, Alexandra},
   article_location = {Zagreb},
   article_number = {3},
   doi = {https://doi.org/10.24869/psyd.2018.356},
   keywords = {modafinil; prenatal administration; locomotion; phagocytosis; mice},
   language = {eng},
   issn = {0353-5053},
   journal = {Psychiatria danubina},
   title = {PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE},
   volume = {30},
   year = {2018}
}

TY  - JOUR
ID  - 1443237
AU  - Rudá, Jana - Amchová, Petra - Máchalová, Alena - Pistovčáková, Jana - Šulcová, Alexandra
PY  - 2018
TI  - PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE
JF  - Psychiatria danubina
VL  - 30
IS  - 3
SP  - 356-366
EP  - 356-366
PB  - Medicinska naklada Zagreb
SN  - 03535053
KW  - modafinil
KW  - prenatal administration
KW  - locomotion
KW  - phagocytosis
KW  - mice
N2  - Background: Modafinil is a psychostimulant drug prescribed mainly for treatment of narcolepsy but is used as a "smart drug" by wide populations to increase wakefulness, concentration and overall mental performance. The aim of this study was to assess potential developmental toxicity of modafinil. Materials and methods: Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestational day (GD) 3 to GD 10 and then a challenge dose on the GD 17. The male offspring were treated analogously at the age of 10 weeks. Changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open-field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-day wash-out period. One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. Results: The most important finding of this study was the immunosuppressing effect on leukocyte activity, hypolocomotion and increased behavioural response to modafinil-induced psychostimulation caused by prenatal exposure to the same drug. We did not detect significantly altered anxiety-related behaviour in any group disregarding the pre- and postnatal treatments. Conclusion: This is the first evidence of developmental toxicity of modafinil which needs to be taken into account as a potential risk factor when modafinil is administered to women who may become or are pregnant.
ER  -

RUDÁ, Jana; Petra AMCHOVÁ; Alena MÁCHALOVÁ; Jana PISTOVČÁKOVÁ a Alexandra ŠULCOVÁ. PRENATAL EXPOSURE TO MODAFINIL ALTERS LOCOMOTOR BEHAVIOUR AND LEUCOCYTE PHAGOCYTOSIS IN MICE. \textit{Psychiatria danubina}. Zagreb: Medicinska naklada Zagreb, 2018, roč.~30, č.~3, s.~356-366. ISSN~0353-5053. Dostupné z: https://doi.org/10.24869/psyd.2018.356.

Přehled o publikaci