STANÍK, Michal, Alexandr POPRACH, D. MACIK, I. CAPAK, Denisa KREJČÍ, N. MARECKOVA, Radek LAKOMÝ, Jiří JARKOVSKÝ a Jan DOLEŽEL. Clinically node-positive bladder cancer: oncological results of induction chemotherapy and consolidative surgery. Neoplasma. Bratislava: Slovenská akademie vied, roč. 65, č. 2, s. 287-291. ISSN 0028-2685. doi:10.4149/neo_2018_170403N239. 2018.
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Základní údaje
Originální název Clinically node-positive bladder cancer: oncological results of induction chemotherapy and consolidative surgery
Autoři STANÍK, Michal (703 Slovensko, garant), Alexandr POPRACH (203 Česká republika), D. MACIK (203 Česká republika), I. CAPAK (203 Česká republika), Denisa KREJČÍ (203 Česká republika, domácí), N. MARECKOVA (203 Česká republika), Radek LAKOMÝ (203 Česká republika), Jiří JARKOVSKÝ (203 Česká republika, domácí) a Jan DOLEŽEL (203 Česká republika).
Vydání Neoplasma, Bratislava, Slovenská akademie vied, 2018, 0028-2685.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30204 Oncology
Stát vydavatele Slovensko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.771
Kód RIV RIV/00216224:14110/18:00104048
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.4149/neo_2018_170403N239
UT WoS 000435149800016
Klíčová slova anglicky urinary bladder neoplasms; lymphadenopathy; combined modality therapy; induction chemotherapy; cystectomy
Štítky 14119612, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Soňa Böhmová, učo 232884. Změněno: 9. 2. 2019 21:39.
Anotace
Patients with clinically node-positive bladder cancer have a poor prognosis, with many receiving only palliative chemotherapy. We evaluated oncological results in bladder cancer patients with clinically regional and supraregional lymphadenopathy treated with induction chemotherapy (IC) and consolidative cystectomy. Twenty-five patients with clinically node-positive bladder cancer (including pelvic and retroperitoneal nodes) were treated with 2-4 cycles of IC followed by consolidative cystectomy between 2010 and 2016. Pathologic complete response (pCR) was defined as no residual tumor in the final specimen (ypT0N0). The 3-year cancer-specific (CSS) and recurrence-free survival (RFS) for the whole cohort were 52% and 39%, respectively. The 3-year RFS differed according to volume of nodal metastases, the rates were 56% for minimal nodal disease (cN1) versus 33% for cN2-3 and 0% for cM1 disease (p<0.001). pCR was seen in 7 (28%) patients; 50% in cN1 versus 13% in cN3-M1. pCR associated with 3-year CSS of 80% versus 45% in patients with persistent disease aft er IC. In conclusion, a multimodal approach to patients with clinically node-positive bladder cancer, consisting of IC followed by consolidative surgery, may achieve long-term survival in selected patients. Better results may be expected in patients with initially minimal nodal burden and complete pathologic response to chemotherapy. Further studies are warranted to improve patient selection for consolidative surgery, especially with supra-regional metastases.
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