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@article{1451297,
author = {Hříbková, Hana and Grabiec, Marta and Klemová, Dobromila and Slaninová, Iva and Wadeley, YuhandMan},
article_location = {Cambridge},
article_number = {3},
doi = {http://dx.doi.org/10.1242/jcs.206896},
keywords = {Embryonic stem cells; Neural stem cell niche; Neural rosette formation; Calcium; Neurogenesis; Adherens junctions; Cytoskeleton proteins},
language = {eng},
issn = {0021-9533},
journal = {Journal of Cell Science},
title = {Calcium signaling mediates five types of cell morphological changes to form neural rosettes},
url = {http://dx.doi.org/10.1242/jcs.206896},
volume = {131},
year = {2018}
}
TY - JOUR
ID - 1451297
AU - Hříbková, Hana - Grabiec, Marta - Klemová, Dobromila - Slaninová, Iva - Wadeley, Yuh-Man
PY - 2018
TI - Calcium signaling mediates five types of cell morphological changes to form neural rosettes
JF - Journal of Cell Science
VL - 131
IS - 3
SP - 1-12
EP - 1-12
PB - Company of Biologists Ltd.
SN - 00219533
KW - Embryonic stem cells
KW - Neural stem cell niche
KW - Neural rosette formation
KW - Calcium
KW - Neurogenesis
KW - Adherens junctions
KW - Cytoskeleton proteins
UR - http://dx.doi.org/10.1242/jcs.206896
N2 - Neural rosette formation is a critical morphogenetic process during neural development, whereby neural stem cells are enclosed in rosette niches to equipoise proliferation and differentiation. How neural rosettes form and provide a regulatory micro-environment remains to be elucidated. We employed the human embryonic stem cell-based neural rosette system to investigate the structural development and function of neural rosettes. Our study shows that neural rosette formation consists of five types of morphological change: intercalation, constriction, polarization, elongation and lumen formation. Ca2+ signaling plays a pivotal role in the five steps by regulating the actions of the cytoskeletal complexes, actin, myosin II and tubulin during intercalation, constriction and elongation. These, in turn, control the polarizing elements, ZO-1, PARD3 and beta-catenin during polarization and lumen production for neural rosette formation. We further demonstrate that the dismantlement of neural rosettes, mediated by the destruction of cytoskeletal elements, promotes neurogenesis and astrogenesis prematurely, indicating that an intact rosette structure is essential for orderly neural development.
ER -
HŘÍBKOVÁ, Hana, Marta GRABIEC, Dobromila KLEMOVÁ, Iva SLANINOVÁ a Yuh-Man WADELEY. Calcium signaling mediates five types of cell morphological changes to form neural rosettes. \textit{Journal of Cell Science}. Cambridge: Company of Biologists Ltd., 2018, roč.~131, č.~3, s.~1-12. ISSN~0021-9533. Dostupné z: https://dx.doi.org/10.1242/jcs.206896.
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