VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ and Michal MASAŘÍK. Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2018, vol. 8, No 10370, p. 1-7. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-28672-8. |
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@article{1454676, author = {Všianský, Vít and Gumulec, Jaromír and Raudenská, Martina and Masařík, Michal}, article_location = {LONDON}, article_number = {10370}, doi = {http://dx.doi.org/10.1038/s41598-018-28672-8}, keywords = {c-Met}, language = {eng}, issn = {2045-2322}, journal = {Scientific reports}, title = {Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis}, volume = {8}, year = {2018} }
TY - JOUR ID - 1454676 AU - Všianský, Vít - Gumulec, Jaromír - Raudenská, Martina - Masařík, Michal PY - 2018 TI - Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis JF - Scientific reports VL - 8 IS - 10370 SP - 1-7 EP - 1-7 PB - NATURE PUBLISHING GROUP SN - 20452322 KW - c-Met N2 - This meta-analysis aims to evaluate the effects of high c-Met levels in head and neck squamous cell carcinomas (HNSCC) on survival and clinicopathological features. Publications concerned with the clinical significance of c-Met protein expression in HNSCC were identified from the Scopus and Web of Science database searches. To elucidate the relationship between c-Met expression and clinical outcomes, a meta-analysis of the selected articles was conducted. Seventeen publications involving a total of 1724 patients met the inclusion criteria. c-Met overexpression was significantly correlated with poor overall survival (hazard ratio (HR) = 2.19, 95% confidence interval (CI) = 1.55-3.10). c-Met immunohistochemical staining positivity was also associated with worse relapse-free survival (HR = 1.64, 95% CI = 1.24-2.17) and presence of regional lymph node metastases (odds ratio (OR) = 1.76, 95% CI = 1.26-2.45). High levels of c-Met expression in HNSCC predict unfavorable prognosis associated with common clinicopathological features. ER -
VŠIANSKÝ, Vít, Jaromír GUMULEC, Martina RAUDENSKÁ and Michal MASAŘÍK. Prognostic role of c-Met in head and neck squamous cell cancer tissues: a meta-analysis. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2018, vol.~8, No~10370, p.~1-7. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-28672-8.
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