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@article{1455136,
author = {Ghosh, Somadri and Scozzaro, Samuel and Ramos, Ana Raque and Delcambre, Seprimebastien and Chevalier, Cleprimement and Krejčí, Pavel and Erneux, Christophe},
article_location = {Cambridge},
article_number = {16},
doi = {http://dx.doi.org/10.1242/jcs.216408},
keywords = {SHIP2; Phosphoinositide; Cell migration; Breast cancer cell},
language = {eng},
issn = {0021-9533},
journal = {Journal of Cell Science},
title = {Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells},
volume = {131},
year = {2018}
}
TY - JOUR
ID - 1455136
AU - Ghosh, Somadri - Scozzaro, Samuel - Ramos, Ana Raque - Delcambre, Seprimebastien - Chevalier, Cleprimement - Krejčí, Pavel - Erneux, Christophe
PY - 2018
TI - Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells
JF - Journal of Cell Science
VL - 131
IS - 16
SP - 1-12
EP - 1-12
PB - Company of Biologists Ltd.
SN - 00219533
KW - SHIP2
KW - Phosphoinositide
KW - Cell migration
KW - Breast cancer cell
N2 - Metastasis of breast cancer cells to distant organs is responsible for similar to 50% of breast cancer-related deaths in women worldwide. SHIP2 (also known as INPPL1) is a phosphoinositide 5-phosphatase for phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2]. Here we show, through depletion of SHIP2 in triple negative MDA-MB-231 cells and the use of SHIP2 inhibitors, that cell migration appears to be positively controlled by SHIP2. The effect of SHIP2 on migration, as observed in MDA-MB-231 cells, appears to be mediated by PI(3,4) P2. Adhesion on fibronectin is always increased in SHIP2-depleted cells. Apoptosis measured in MDA-MB-231 cells is also increased in SHIP2-depleted cells as compared to control cells. In xenograft mice, SHIP2-depleted MDA-MB-231 cells form significantly smaller tumors than those formed by control cells and less metastasis is detected in lung sections. Our data reveal a general role for SHIP2 in the control of cell migration in breast cancer cells and a second messenger role for PI(3,4) P2 in the migration mechanism. In MDA-MB-231 cells, SHIP2 has a function in apoptosis in cells incubated in vitro and in mouse tumor-derived cells, which could account for its role on tumor growth determined in vivo.
ER -
GHOSH, Somadri, Samuel SCOZZARO, Ana Raque RAMOS, Seprimebastien DELCAMBRE, Cleprimement CHEVALIER, Pavel KREJČÍ a Christophe ERNEUX. Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells. \textit{Journal of Cell Science}. Cambridge: Company of Biologists Ltd., 2018, roč.~131, č.~16, s.~1-12. ISSN~0021-9533. Dostupné z: https://dx.doi.org/10.1242/jcs.216408.
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