Lymphocyte populations and their change during five-year
glatiramer acetate treatment

J 2018

Lymphocyte populations and their change during five-year glatiramer acetate treatment

PAVELEK, Zbyšek, Oldřich VYŠATA, Lukáš SOBÍŠEK, Blanka KLÍMOVA, Ctirad ANDRÝS et. al.

Základní údaje

Originální název

Lymphocyte populations and their change during five-year glatiramer acetate treatment

Autoři

PAVELEK, Zbyšek (203 Česká republika, garant), Oldřich VYŠATA, Lukáš SOBÍŠEK (203 Česká republika), Blanka KLÍMOVA (203 Česká republika), Ctirad ANDRÝS (203 Česká republika), Doris VOKURKOVÁ (203 Česká republika), Radka MAZUROVÁ, Pavel ŠTOURAČ (203 Česká republika, domácí) a Martin VALIŠ (203 Česká republika)

Vydání

Neurologia i Neurochirurgia Polska, Poznan, Termedia Publishing House LTD, 2018, 0028-3843

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.006

Kód RIV

RIV/00216224:14110/18:00104209

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.pjnns.2018.08.001

UT WoS

000446401500007

Klíčová slova anglicky

Multiple sclerosis; Lymphocytes; Glatiramer acetate; Parameters; Treatment

Štítky

14110221, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2019 15:46, Soňa Böhmová

Anotace

V originále

Background: The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA). Methods: A total of 113 patients were included in this study. Patients were treated with glatiramer acetate (subcutaneous injection, 20 mg, each day). Peripheral blood samples were obtained just prior to treatment as well as 5 years after GA treatment. All the calculations were performed with the statistical system R (r-project.org). Results: After 5 years of treatment, a significant decrease was found in the absolute and relative CD3+/CD69+ counts, the absolute and relative CD69 counts, the relative CD8+/CD38+ count and the relative CD38 count. A significant increase was found in the absolute and relative CD5+/CD45RA+ counts and the absolute CD5+/CD45RO+ count after 5 years of treatment. Conclusion: This study presents some parameters that were affected by long-term GA treatment. (C) 2018 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.

Citovat

PAVELEK, Zbyšek, Oldřich VYŠATA, Lukáš SOBÍŠEK, Blanka KLÍMOVA, Ctirad ANDRÝS, Doris VOKURKOVÁ, Radka MAZUROVÁ, Pavel ŠTOURAČ a Martin VALIŠ. Lymphocyte populations and their change during five-year glatiramer acetate treatment. Neurologia i Neurochirurgia Polska. Poznan: Termedia Publishing House LTD, 2018, roč. 52, č. 5, s. 587-592. ISSN 0028-3843. Dostupné z: https://dx.doi.org/10.1016/j.pjnns.2018.08.001.

@article{1455737,
   author = {Pavelek, Zbyšek and Vyšata, Oldřich and Sobíšek, Lukáš and Klímova, Blanka and Andrýs, Ctirad and Vokurková, Doris and Mazurová, Radka and Štourač, Pavel and Vališ, Martin},
   article_location = {Poznan},
   article_number = {5},
   doi = {http://dx.doi.org/10.1016/j.pjnns.2018.08.001},
   keywords = {Multiple sclerosis; Lymphocytes; Glatiramer acetate; Parameters; Treatment},
   language = {eng},
   issn = {0028-3843},
   journal = {Neurologia i Neurochirurgia Polska},
   title = {Lymphocyte populations and their change during five-year glatiramer acetate treatment},
   volume = {52},
   year = {2018}
}

TY  - JOUR
ID  - 1455737
AU  - Pavelek, Zbyšek - Vyšata, Oldřich - Sobíšek, Lukáš - Klímova, Blanka - Andrýs, Ctirad - Vokurková, Doris - Mazurová, Radka - Štourač, Pavel - Vališ, Martin
PY  - 2018
TI  - Lymphocyte populations and their change during five-year glatiramer acetate treatment
JF  - Neurologia i Neurochirurgia Polska
VL  - 52
IS  - 5
SP  - 587-592
EP  - 587-592
PB  - Termedia Publishing House LTD
SN  - 00283843
KW  - Multiple sclerosis
KW  - Lymphocytes
KW  - Glatiramer acetate
KW  - Parameters
KW  - Treatment
N2  - Background: The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA). Methods: A total of 113 patients were included in this study. Patients were treated with glatiramer acetate (subcutaneous injection, 20 mg, each day). Peripheral blood samples were obtained just prior to treatment as well as 5 years after GA treatment. All the calculations were performed with the statistical system R (r-project.org). Results: After 5 years of treatment, a significant decrease was found in the absolute and relative CD3+/CD69+ counts, the absolute and relative CD69 counts, the relative CD8+/CD38+ count and the relative CD38 count. A significant increase was found in the absolute and relative CD5+/CD45RA+ counts and the absolute CD5+/CD45RO+ count after 5 years of treatment. Conclusion: This study presents some parameters that were affected by long-term GA treatment. (C) 2018 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.
ER  -

PAVELEK, Zbyšek, Oldřich VYŠATA, Lukáš SOBÍŠEK, Blanka KLÍMOVA, Ctirad ANDRÝS, Doris VOKURKOVÁ, Radka MAZUROVÁ, Pavel ŠTOURAČ a Martin VALIŠ. Lymphocyte populations and their change during five-year glatiramer acetate treatment. \textit{Neurologia i Neurochirurgia Polska}. Poznan: Termedia Publishing House LTD, 2018, roč.~52, č.~5, s.~587-592. ISSN~0028-3843. Dostupné z: https://dx.doi.org/10.1016/j.pjnns.2018.08.001.

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