Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis
or Memory B Cell Formation in IGHD Haploinsufficient Humans

J 2018

Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans

NECHVÁTALOVÁ, Jana; Sophinus J. W. BARTOL; Zita CHOVANCOVÁ; Louis BOON; Marcela VLKOVÁ et al.

Základní údaje

Originální název

Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans

Autoři

NECHVÁTALOVÁ, Jana; Sophinus J. W. BARTOL; Zita CHOVANCOVÁ; Louis BOON; Marcela VLKOVÁ a Menno C. van ZELM

Vydání

Journal of immunology, Bethesda, American association of immunologists, 2018, 0022-1767

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.718

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/18:00106940

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Surface IgD

Štítky

14110114, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2019 19:54, Soňa Böhmová

Anotace

V originále

Surface IgD is coexpressed with IgM on naive mature B cells. Still, the role of surface IgD remains enigmatic even 50 y after its initial discovery. In this study, we examined the in vivo role of surface IgD in human B cell homeostasis and Ab responses in four individuals with heterozygous nonsense mutations in IGHD. All IGHD heterozygous individuals had normal numbers of B cells and serum Igs and did not show signs of immunodeficiency or immune dysregulation. IgD(+) and IgD(-) naive mature B cells were present in equal numbers and showed similar immunophenotypes, except for decreased expression of CD79b in the IgD(-) subset. Furthermore, both IgD(+) and IgD(-) naive mature B cells had normal replication histories and similar capacities to differentiate into plasma cells upon in vitro stimulation, and Ig class-switched memory B cells showed similar levels of somatic hypermutations. Thus, human B cells lacking IgD expression develop normally and generate immunological memory in vivo, suggesting that surface IgD might function more restrictedly in regulating of B cell activation to specific antigenic structures.

Návaznosti

NV15-28732A, projekt VaV

Název: Vliv granulocytů a monocytů na vznik a rozvoj imunodeficitních chorob a dalších imunopatologických dějů

Citovat

NECHVÁTALOVÁ, Jana; Sophinus J. W. BARTOL; Zita CHOVANCOVÁ; Louis BOON; Marcela VLKOVÁ a Menno C. van ZELM. Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans. Journal of immunology. Bethesda: American association of immunologists, 2018, roč. 201, č. 7, s. 1928-1935. ISSN 0022-1767. Dostupné z: https://doi.org/10.4049/jimmunol.1800767.

@article{1455936,
   author = {Nechvátalová, Jana and Bartol, Sophinus J. W. and Chovancová, Zita and Boon, Louis and Vlková, Marcela and Zelm, Menno C. van},
   article_location = {Bethesda},
   article_number = {7},
   doi = {https://doi.org/10.4049/jimmunol.1800767},
   keywords = {Surface IgD},
   language = {eng},
   issn = {0022-1767},
   journal = {Journal of immunology},
   title = {Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans},
   volume = {201},
   year = {2018}
}

TY  - JOUR
ID  - 1455936
AU  - Nechvátalová, Jana - Bartol, Sophinus J. W. - Chovancová, Zita - Boon, Louis - Vlková, Marcela - Zelm, Menno C. van
PY  - 2018
TI  - Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans
JF  - Journal of immunology
VL  - 201
IS  - 7
SP  - 1928-1935
EP  - 1928-1935
PB  - American association of immunologists
SN  - 00221767
KW  - Surface IgD
N2  - Surface IgD is coexpressed with IgM on naive mature B cells. Still, the role of surface IgD remains enigmatic even 50 y after its initial discovery. In this study, we examined the in vivo role of surface IgD in human B cell homeostasis and Ab responses in four individuals with heterozygous nonsense mutations in IGHD. All IGHD heterozygous individuals had normal numbers of B cells and serum Igs and did not show signs of immunodeficiency or immune dysregulation. IgD(+) and IgD(-) naive mature B cells were present in equal numbers and showed similar immunophenotypes, except for decreased expression of CD79b in the IgD(-) subset. Furthermore, both IgD(+) and IgD(-) naive mature B cells had normal replication histories and similar capacities to differentiate into plasma cells upon in vitro stimulation, and Ig class-switched memory B cells showed similar levels of somatic hypermutations. Thus, human B cells lacking IgD expression develop normally and generate immunological memory in vivo, suggesting that surface IgD might function more restrictedly in regulating of B cell activation to specific antigenic structures.
ER  -

NECHVÁTALOVÁ, Jana; Sophinus J. W. BARTOL; Zita CHOVANCOVÁ; Louis BOON; Marcela VLKOVÁ a Menno C. van ZELM. Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans. \textit{Journal of immunology}. Bethesda: American association of immunologists, 2018, roč.~201, č.~7, s.~1928-1935. ISSN~0022-1767. Dostupné z: https://doi.org/10.4049/jimmunol.1800767.

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