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@article{1461096,
author = {Maňousek, Jan and Andršová, Irena and Stejskal, Vera and Vlašínová, Jitka and Sepši, Milan and Kuta, Jan and Klánová, Jana and Mazík, Michal and Jarkovský, Jiří and Šnajdrová, Lenka and Benešová, Klára and Novotný, Tomáš and Zadáková, Andrea and Špinar, Jindřich},
article_location = {Oxford},
article_number = {9},
doi = {http://dx.doi.org/10.1093/europace/eux227},
keywords = {Pacemaker; Implantable cardioverter-defibrillator; Late complication; Metal pollutants; Delayed-type hypersensitivity; Lymphocyte transformation test},
language = {eng},
issn = {1099-5129},
journal = {EP Europace},
title = {Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices},
volume = {20},
year = {2018}
}
TY - JOUR
ID - 1461096
AU - Maňousek, Jan - Andršová, Irena - Stejskal, Vera - Vlašínová, Jitka - Sepši, Milan - Kuta, Jan - Klánová, Jana - Mazík, Michal - Jarkovský, Jiří - Šnajdrová, Lenka - Benešová, Klára - Novotný, Tomáš - Zadáková, Andrea - Špinar, Jindřich
PY - 2018
TI - Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices
JF - EP Europace
VL - 20
IS - 9
SP - "E140"-"E147"
EP - "E140"-"E147"
PB - Oxford University Press
SN - 10995129
KW - Pacemaker
KW - Implantable cardioverter-defibrillator
KW - Late complication
KW - Metal pollutants
KW - Delayed-type hypersensitivity
KW - Lymphocyte transformation test
N2 - Aims To evaluate whether patients with late complications of pacemakers or implantable cardioverter-defibrillators have hypersensitivity reactions to some of the materials used in generators or in electrodes, or to environmental metal burden. Methods and results The cohort consisted of 20 men and 4 women (mean age: 62.3 +/- 17.2 years) who had a history of late complications of implanted devices. The control group involved 25 men and 8 women (mean age: 64.6 +/- 14.0 years) who had comparable devices, but no history of late complications. Lymphocyte transformation test was used to evaluate hypersensitivity to eight metal pollutants (antimony, manganese, mercury, molybdenum, nickel, platinum, tin, and titanium) selected by results of questionnaires on environmental burden, and by material analysis of generators and electrode surfaces. Exposures to metal pollutants were approximately the same in patients and in controls. Titanium alloy used in generators contained at least 99.32% of titanium and trace levels of other metals; higher levels of tin and platinum were detected in electrode surfaces. Hypersensitivity reactions to mercury and tin were significantly more frequent in patients than in controls (patients and controls: mercury: 68.2 and 31.1%, respectively; P = 0.022; tin: 25.0 and 3.2%, respectively; P = 0.035). In contrast, hypersensitivity to manganese was significantly more frequent in controls than in patients (patients and controls: 13.6 and 50.0%, respectively; P = 0.008). Conclusion Our findings suggest a possible relation between hypersensitivity to metals used in implantable devices or to environmental metal burden and the occurrence of their late complications.
ER -
MAŇOUSEK, Jan, Irena ANDRŠOVÁ, Vera STEJSKAL, Jitka VLAŠÍNOVÁ, Milan SEPŠI, Jan KUTA, Jana KLÁNOVÁ, Michal MAZÍK, Jiří JARKOVSKÝ, Lenka ŠNAJDROVÁ, Klára BENEŠOVÁ, Tomáš NOVOTNÝ, Andrea ZADÁKOVÁ a Jindřich ŠPINAR. Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices. \textit{EP Europace}. Oxford: Oxford University Press, 2018, roč.~20, č.~9, s.~''E140''-''E147'', 8 s. ISSN~1099-5129. Dostupné z: https://dx.doi.org/10.1093/europace/eux227.
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