SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING
PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL
DIAGNOSTIC PITFALL

J 2017

SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL

BENEJ, Michal; Iva ZAMBO; Ondřej BILEK a Ivan ČAPOV

Základní údaje

Originální název

SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL

Autoři

BENEJ, Michal; Iva ZAMBO; Ondřej BILEK a Ivan ČAPOV

Vydání

POLISH JOURNAL OF PATHOLOGY, CRACOW, VESALIUS UNIV MEDICAL PUBL, 2017, 1233-9687

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30109 Pathology

Stát vydavatele

Polsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.865

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/17:00104426

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

neuroendocrine tumor; malignant paraganglioma; hereditary syndromes; thyroid transcription factor 1

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 11. 2018 11:57, Soňa Böhmová

Anotace

V originále

Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum. This is the first report of TTF-1 expression in paraganglioma. To avoid misdiagnosis, careful clinical and pathological examination of any tumor with organoid growths pattern is necessary.

Citovat

BENEJ, Michal; Iva ZAMBO; Ondřej BILEK a Ivan ČAPOV. SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL. POLISH JOURNAL OF PATHOLOGY. CRACOW: VESALIUS UNIV MEDICAL PUBL, 2017, roč. 68, č. 4, s. 354-358. ISSN 1233-9687. Dostupné z: https://doi.org/10.5114/pjp.2017.73931.

@article{1466078,
   author = {Benej, Michal and Zambo, Iva and Bilek, Ondřej and Čapov, Ivan},
   article_location = {CRACOW},
   article_number = {4},
   doi = {https://doi.org/10.5114/pjp.2017.73931},
   keywords = {neuroendocrine tumor; malignant paraganglioma; hereditary syndromes; thyroid transcription factor 1},
   language = {eng},
   issn = {1233-9687},
   journal = {POLISH JOURNAL OF PATHOLOGY},
   title = {SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL},
   volume = {68},
   year = {2017}
}

TY  - JOUR
ID  - 1466078
AU  - Benej, Michal - Zambo, Iva - Bilek, Ondřej - Čapov, Ivan
PY  - 2017
TI  - SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL
JF  - POLISH JOURNAL OF PATHOLOGY
VL  - 68
IS  - 4
SP  - 354-358
EP  - 354-358
PB  - VESALIUS UNIV MEDICAL PUBL
SN  - 12339687
KW  - neuroendocrine tumor
KW  - malignant paraganglioma
KW  - hereditary syndromes
KW  - thyroid transcription factor 1
N2  - Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum. This is the first report of TTF-1 expression in paraganglioma. To avoid misdiagnosis, careful clinical and pathological examination of any tumor with organoid growths pattern is necessary.
ER  -

BENEJ, Michal; Iva ZAMBO; Ondřej BILEK a Ivan ČAPOV. SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL. \textit{POLISH JOURNAL OF PATHOLOGY}. CRACOW: VESALIUS UNIV MEDICAL PUBL, 2017, roč.~68, č.~4, s.~354-358. ISSN~1233-9687. Dostupné z: https://doi.org/10.5114/pjp.2017.73931.

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