a 2018

Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK et. al.

Basic information

Original name

Serotonin transporter gene (SLC6A4) variability in patients with recurrent aphthous stomatitis

Authors

SLEZÁKOVÁ, Simona (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Jiřina BÁRTOVÁ (203 Czech Republic), Jitka PETANOVÁ (203 Czech Republic), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

XIX. setkání biochemiků a molekulárních biologů, Brno, 2018

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30208 Dentistry, oral surgery and medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/18:00101355

Organization unit

Faculty of Medicine

Keywords in English

serotonin transporter gene; polymorphism; recurrent aphthous stomatitis
Změněno: 15/1/2019 15:27, Mgr. et Mgr. Simona Slezáková, Ph.D.

Abstract

V originále

Background: Recurrent aphthous stomatitis (RAS) is a common chronic inflammatory disease of oral mucosa characterized by single or multiple painful erosions and ulcers. The etiopathogenesis of RAS has not been elucidated yet, but anxiety and stress are considered as one of the main factors influencing the manifestation of RAS. Variability in serotonin transporter gene (SLC6A4), modulating the magnitude and duration of serotonergic neurotransmission, has been previously associated with RAS. The aim of our study was to analyse five polymorphisms in the SLC6A4 gene in patients with RAS and healthy controls. Subjects and methods: Totally, 239 subjects were enrolled in this case-control study: 86 patients with RAS and 153 healthy individuals. The serotonin transporter length polymorphic region (5-HTTLPR) polymorphism, variable number tandem repeat (STin2) and single nucleotide polymorphisms (rs25531, rs1042173, rs3813034) in the SLC6A4 gene were determined by polymerase chain reaction with/without restriction analysis. Results: The allele, genotype and haplotype frequencies of all five studied polymorphisms between RAS patients and healthy controls were similar (P>0.05). Nevertheless, the distribution of allele frequencies of 5-HTTLPR SLC6A4 polymorphism was marginally different between patients with RAS and healthy controls (P=0.07). Conclusions: In contrast to previous studies in Brazilian and Iranian populations, our study did not confirm the association between the SLC6A4 gene variability and susceptibility to RAS.

Links

GB14-37368G, research and development project
Name: Centrum orofaciálního vývoje a regenerace
Investor: Czech Science Foundation
MUNI/A/1008/2017, interní kód MU
Name: Etiopatogenetické aspekty, diagnostika a léčba vybraných onemocnění dutiny ústní
Investor: Masaryk University, Category A
NV15-29336A, research and development project
Name: Změny imunologické reaktivity u pacientů s recidivujícími aftami
ROZV/24/LF/2018, interní kód MU
Name: LF - Příspěvek na IP 2108
Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects