The role of 3 ' end uridylation in RNA metabolism and cellular
physiology

J 2018

The role of 3 ' end uridylation in RNA metabolism and cellular physiology

ZIGÁČKOVÁ, Dagmar a Štěpánka VAŇÁČOVÁ

Základní údaje

Originální název

The role of 3 ' end uridylation in RNA metabolism and cellular physiology

Autoři

ZIGÁČKOVÁ, Dagmar a Štěpánka VAŇÁČOVÁ

Vydání

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, LONDON, ROYAL SOC, 2018, 0962-8436

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.139

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/18:00101443

Organizační jednotka

Středoevropský technologický institut

Klíčová slova anglicky

RNA uridylation; tutase; RNA modification; RNA surveillance; RNA processing; RNA degradation

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 3. 2019 17:13, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Most eukaryotic RNAs are posttranscriptionally modified. The majority of modifications promote RNA maturation, others may regulate function and stability. The 3' terminal non-templated oligouridylation is a widespread modification affecting many cellular RNAs at some stage of their life cycle. It has diverse roles in RNA metabolism. The most prevalent is the regulation of stability and quality control. On the cellular and organismal level, it plays a critical role in a number of pathways, such as cell cycle regulation, cell death, development or viral infection. Defects in uridylation have been linked to several diseases. This review summarizes the current knowledge about the role of the 3' terminal oligo(U)-tailing in biology of various RNAs in eukaryotes and describes key factors involved in these pathways. This article is part of the theme issue '5' and 3' modifications controlling RNA degradation'.

Návaznosti

GAP305/11/1095, projekt VaV

Název: Funkční a biochemická charakterizace proteinu Dis3L2, třetího lidského homologu hlavní kvasinkové exosomové nukleázy Dis3p

Investor: Grantová agentura ČR, Funkční a biochemická charakterizace proteinu Dis3L2, třetího lidského homologu hlavní kvasinkové exosomové nukleázy Dis3p

GA16-21341S, projekt VaV

Název: Studium úlohy uridylace RNA v lidských buňkách

Investor: Grantová agentura ČR, Studium úlohy uridylace RNA v lidských buňkách

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

ZIGÁČKOVÁ, Dagmar a Štěpánka VAŇÁČOVÁ. The role of 3 ' end uridylation in RNA metabolism and cellular physiology. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. LONDON: ROYAL SOC, 2018, roč. 373, č. 1762, s. 20180171-20180184. ISSN 0962-8436. Dostupné z: https://doi.org/10.1098/rstb.2018.0171.

@article{1479521,
   author = {Zigáčková, Dagmar and Vaňáčová, Štěpánka},
   article_location = {LONDON},
   article_number = {1762},
   doi = {https://doi.org/10.1098/rstb.2018.0171},
   keywords = {RNA uridylation; tutase; RNA modification; RNA surveillance; RNA processing; RNA degradation},
   language = {eng},
   issn = {0962-8436},
   journal = {PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES},
   title = {The role of 3 ' end uridylation in RNA metabolism and cellular physiology},
   url = {https://royalsocietypublishing.org/doi/10.1098/rstb.2018.0171},
   volume = {373},
   year = {2018}
}

TY  - JOUR
ID  - 1479521
AU  - Zigáčková, Dagmar - Vaňáčová, Štěpánka
PY  - 2018
TI  - The role of 3 ' end uridylation in RNA metabolism and cellular physiology
JF  - PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
VL  - 373
IS  - 1762
SP  - 20180171
EP  - 20180171
PB  - ROYAL SOC
SN  - 09628436
KW  - RNA uridylation
KW  - tutase
KW  - RNA modification
KW  - RNA surveillance
KW  - RNA processing
KW  - RNA degradation
UR  - https://royalsocietypublishing.org/doi/10.1098/rstb.2018.0171
N2  - Most eukaryotic RNAs are posttranscriptionally modified. The majority of modifications promote RNA maturation, others may regulate function and stability. The 3' terminal non-templated oligouridylation is a widespread modification affecting many cellular RNAs at some stage of their life cycle. It has diverse roles in RNA metabolism. The most prevalent is the regulation of stability and quality control. On the cellular and organismal level, it plays a critical role in a number of pathways, such as cell cycle regulation, cell death, development or viral infection. Defects in uridylation have been linked to several diseases. This review summarizes the current knowledge about the role of the 3' terminal oligo(U)-tailing in biology of various RNAs in eukaryotes and describes key factors involved in these pathways. This article is part of the theme issue '5' and 3' modifications controlling RNA degradation'.
ER  -

ZIGÁČKOVÁ, Dagmar a Štěpánka VAŇÁČOVÁ. The role of 3 ' end uridylation in RNA metabolism and cellular physiology. \textit{PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES}. LONDON: ROYAL SOC, 2018, roč.~373, č.~1762, s.~20180171-20180184. ISSN~0962-8436. Dostupné z: https://doi.org/10.1098/rstb.2018.0171.

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