PIWI-piRNA pathway: Setting the pace of aging by reducing DNA
damage

J 2018

PIWI-piRNA pathway: Setting the pace of aging by reducing DNA damage

LENÁRT, Peter, Jan NOVÁK a Julie BIENERTOVÁ VAŠKŮ

Základní údaje

Originální název

PIWI-piRNA pathway: Setting the pace of aging by reducing DNA damage

Autoři

LENÁRT, Peter (703 Slovensko, domácí), Jan NOVÁK (203 Česká republika, domácí) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, garant, domácí)

Vydání

Mechanisms of ageing and development, Ireland, Elsevier Science Ireland, 2018, 0047-6374

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30227 Geriatrics and gerontology

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.603

Kód RIV

RIV/00216224:14110/18:00105074

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.mad.2018.03.009

UT WoS

000437068900004

Klíčová slova anglicky

PIWI; piRNA; Aging; DNA damage; Stress

Štítky

14110518, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 5. 2019 14:35, Soňa Böhmová

Anotace

V originále

Transposable elements (TEs) are powerful drivers of genome evolutionary dynamics but are principally deleterious to the host organism by compromising the integrity and function of the genome. The transposition of TEs may result in mutations and DNA damage. DNA double-strand breaks (DSBs), which may be caused by the transposition, are one of the processes directly linked to aging. TEs may thus be considered to constitute an internal source of aging and the frequency of transposition may, in turn, be considered to affect the pace of aging. The PIWI-piRNA pathway is a widespread strategy used by most animals to effectively suppress transposition. Interestingly, the PIWI-piRNA pathway is expressed predominantly in the animal germline, a more or less continuous immortal lineage set aside after the first few cell divisions of a developing embryo. Recent findings further imply that the PIWI-piRNA pathway and TE suppression constitute an important mechanism regulating aging. This article discusses the proposed role of the PIWI-piRNA pathway in setting the pace of aging as well as the possible mechanisms underlying this process.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

EF16_013/0001761, projekt VaV

Název: RECETOX RI

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

LENÁRT, Peter, Jan NOVÁK a Julie BIENERTOVÁ VAŠKŮ. PIWI-piRNA pathway: Setting the pace of aging by reducing DNA damage. Mechanisms of ageing and development. Ireland: Elsevier Science Ireland, 2018, roč. 173, July, s. 29-38. ISSN 0047-6374. Dostupné z: https://dx.doi.org/10.1016/j.mad.2018.03.009.

@article{1481713,
   author = {Lenárt, Peter and Novák, Jan and Bienertová Vašků, Julie},
   article_location = {Ireland},
   article_number = {July},
   doi = {http://dx.doi.org/10.1016/j.mad.2018.03.009},
   keywords = {PIWI; piRNA; Aging; DNA damage; Stress},
   language = {eng},
   issn = {0047-6374},
   journal = {Mechanisms of ageing and development},
   title = {PIWI-piRNA pathway: Setting the pace of aging by reducing DNA damage},
   url = {https://www.sciencedirect.com/science/article/pii/S0047637418300186},
   volume = {173},
   year = {2018}
}

TY  - JOUR
ID  - 1481713
AU  - Lenárt, Peter - Novák, Jan - Bienertová Vašků, Julie
PY  - 2018
TI  - PIWI-piRNA pathway: Setting the pace of aging by reducing DNA damage
JF  - Mechanisms of ageing and development
VL  - 173
IS  - July
SP  - 29-38
EP  - 29-38
PB  - Elsevier Science Ireland
SN  - 00476374
KW  - PIWI
KW  - piRNA
KW  - Aging
KW  - DNA damage
KW  - Stress
UR  - https://www.sciencedirect.com/science/article/pii/S0047637418300186
L2  - https://www.sciencedirect.com/science/article/pii/S0047637418300186
N2  - Transposable elements (TEs) are powerful drivers of genome evolutionary dynamics but are principally deleterious to the host organism by compromising the integrity and function of the genome. The transposition of TEs may result in mutations and DNA damage. DNA double-strand breaks (DSBs), which may be caused by the transposition, are one of the processes directly linked to aging. TEs may thus be considered to constitute an internal source of aging and the frequency of transposition may, in turn, be considered to affect the pace of aging. The PIWI-piRNA pathway is a widespread strategy used by most animals to effectively suppress transposition. Interestingly, the PIWI-piRNA pathway is expressed predominantly in the animal germline, a more or less continuous immortal lineage set aside after the first few cell divisions of a developing embryo. Recent findings further imply that the PIWI-piRNA pathway and TE suppression constitute an important mechanism regulating aging. This article discusses the proposed role of the PIWI-piRNA pathway in setting the pace of aging as well as the possible mechanisms underlying this process.
ER  -

LENÁRT, Peter, Jan NOVÁK a Julie BIENERTOVÁ VAŠKŮ. PIWI-piRNA pathway: Setting the pace of aging by reducing DNA damage. \textit{Mechanisms of ageing and development}. Ireland: Elsevier Science Ireland, 2018, roč.~173, July, s.~29-38. ISSN~0047-6374. Dostupné z: https://dx.doi.org/10.1016/j.mad.2018.03.009.

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