Alleviation of endoplasmic reticulum stress by
tauroursodeoxycholic acid delays senescence of mouse ovarian
surface epithelium

J 2018

Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium

VAŠÍČKOVÁ, Kateřina; Lukáš MORÁŇ; Dominik GURÍN a Petr VAŇHARA

Základní údaje

Originální název

Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium

Autoři

VAŠÍČKOVÁ, Kateřina; Lukáš MORÁŇ; Dominik GURÍN a Petr VAŇHARA

Vydání

CELL AND TISSUE RESEARCH, Heidelberg, Springer Verlag, 2018, 0302-766X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.360

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/18:00105151

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Ovarian surface epithelium; Endoplasmic reticulum stress; Unfolded protein response; Senescence; Tauroursodeoxycholic acid

Štítky

14110517, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 2. 2019 20:13, Soňa Böhmová

Anotace

V originále

Ovarian surface epithelium (OSE) forms a single layer of mostly cuboidal cells on surface of mammalian ovaries that is inherently exposed to cell stress evoked by tissue damage every ovulation and declines morphologically after menopause. Endoplasmic reticulum (ER) is a principal cell organelle involved in proteosynthesis, but also integrating various stress signals. ER stress evokes a conserved signaling pathway, the unfolded protein response (UPR), leading to cell death or adaptation to stress conditions. In this work, we document that mouse OSE suffers from ER stress during replicative senescence in vitro, develops abnormalities in ER and initiates UPR. Attenuation of ER stress in senescent OSE by tauroursodeoxycholic acid (TUDCA) reconditions ER architecture and leads to delayed onset of senescence. In summary, we show for the first time a mutual molecular link between ER stress response and replicative senescence leading to phenotypic changes of non-malignant ovarian surface epithelium.

Návaznosti

EE2.3.20.0185, projekt VaV

Název: Centrum analýz a modelování tkání a orgánů

MUNI/A/1298/2017, interní kód MU

Název: Zdroje pro tkáňové inženýrství 8 (Akronym: TissueEng 8)

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 8, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

VAŠÍČKOVÁ, Kateřina; Lukáš MORÁŇ; Dominik GURÍN a Petr VAŇHARA. Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium. CELL AND TISSUE RESEARCH. Heidelberg: Springer Verlag, 2018, roč. 374, č. 3, s. 643-652. ISSN 0302-766X. Dostupné z: https://doi.org/10.1007/s00441-018-2888-9.

@article{1482484,
   author = {Vašíčková, Kateřina and Moráň, Lukáš and Gurín, Dominik and Vaňhara, Petr},
   article_location = {Heidelberg},
   article_number = {3},
   doi = {https://doi.org/10.1007/s00441-018-2888-9},
   keywords = {Ovarian surface epithelium; Endoplasmic reticulum stress; Unfolded protein response; Senescence; Tauroursodeoxycholic acid},
   language = {eng},
   issn = {0302-766X},
   journal = {CELL AND TISSUE RESEARCH},
   title = {Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium},
   url = {https://link.springer.com/article/10.1007%2Fs00441-018-2888-9},
   volume = {374},
   year = {2018}
}

TY  - JOUR
ID  - 1482484
AU  - Vašíčková, Kateřina - Moráň, Lukáš - Gurín, Dominik - Vaňhara, Petr
PY  - 2018
TI  - Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium
JF  - CELL AND TISSUE RESEARCH
VL  - 374
IS  - 3
SP  - 643-652
EP  - 643-652
PB  - Springer Verlag
SN  - 0302766X
KW  - Ovarian surface epithelium
KW  - Endoplasmic reticulum stress
KW  - Unfolded protein response
KW  - Senescence
KW  - Tauroursodeoxycholic acid
UR  - https://link.springer.com/article/10.1007%2Fs00441-018-2888-9
N2  - Ovarian surface epithelium (OSE) forms a single layer of mostly cuboidal cells on surface of mammalian ovaries that is inherently exposed to cell stress evoked by tissue damage every ovulation and declines morphologically after menopause. Endoplasmic reticulum (ER) is a principal cell organelle involved in proteosynthesis, but also integrating various stress signals. ER stress evokes a conserved signaling pathway, the unfolded protein response (UPR), leading to cell death or adaptation to stress conditions. In this work, we document that mouse OSE suffers from ER stress during replicative senescence in vitro, develops abnormalities in ER and initiates UPR. Attenuation of ER stress in senescent OSE by tauroursodeoxycholic acid (TUDCA) reconditions ER architecture and leads to delayed onset of senescence. In summary, we show for the first time a mutual molecular link between ER stress response and replicative senescence leading to phenotypic changes of non-malignant ovarian surface epithelium.
ER  -

VAŠÍČKOVÁ, Kateřina; Lukáš MORÁŇ; Dominik GURÍN a Petr VAŇHARA. Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium. \textit{CELL AND TISSUE RESEARCH}. Heidelberg: Springer Verlag, 2018, roč.~374, č.~3, s.~643-652. ISSN~0302-766X. Dostupné z: https://doi.org/10.1007/s00441-018-2888-9.

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