LEE, Y., N.H. KIM, E.S. CHO, J.H. YANG, Y.H. CHA, H.E. KANG, J.S. YUN, S.B. CHO, S.H. LEE, Petra PACLÍKOVÁ, Tomasz Witold RADASZKIEWICZ, Vítězslav BRYJA, C.G. KANG, Y.S. YUK, S.Y. CHA, S.Y. KIM, H.S. KIM a J.I. YOOK. Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner. Nature Communications. London: Nature Publishing Group, 2018, roč. 9, č. 1, s. 1-16. ISSN 2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-018-04757-w. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1483380, author = {Lee, Y. and Kim, N.H. and Cho, E.S. and Yang, J.H. and Cha, Y.H. and Kang, H.E. and Yun, J.S. and Cho, S.B. and Lee, S.H. and Paclíková, Petra and Radaszkiewicz, Tomasz Witold and Bryja, Vítězslav and Kang, C.G. and Yuk, Y.S. and Cha, S.Y. and Kim, S.Y. and Kim, H.S. and Yook, J.I.}, article_location = {London}, article_number = {1}, doi = {http://dx.doi.org/10.1038/s41467-018-04757-w}, keywords = {ACTIVATED PROTEIN-KINASE; PLANAR CELL POLARITY; ORGAN SIZE CONTROL; HIPPO PATHWAY; BETA-CATENIN; ENERGY STRESS; CONTACT INHIBITION; SIGNALING-PATHWAY; CANCER; LKB1}, language = {eng}, issn = {2041-1723}, journal = {Nature Communications}, title = {Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner}, url = {https://www.nature.com/articles/s41467-018-04757-w}, volume = {9}, year = {2018} }
TY - JOUR ID - 1483380 AU - Lee, Y. - Kim, N.H. - Cho, E.S. - Yang, J.H. - Cha, Y.H. - Kang, H.E. - Yun, J.S. - Cho, S.B. - Lee, S.H. - Paclíková, Petra - Radaszkiewicz, Tomasz Witold - Bryja, Vítězslav - Kang, C.G. - Yuk, Y.S. - Cha, S.Y. - Kim, S.Y. - Kim, H.S. - Yook, J.I. PY - 2018 TI - Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner JF - Nature Communications VL - 9 IS - 1 SP - 1-16 EP - 1-16 PB - Nature Publishing Group SN - 20411723 KW - ACTIVATED PROTEIN-KINASE KW - PLANAR CELL POLARITY KW - ORGAN SIZE CONTROL KW - HIPPO PATHWAY KW - BETA-CATENIN KW - ENERGY STRESS KW - CONTACT INHIBITION KW - SIGNALING-PATHWAY KW - CANCER KW - LKB1 UR - https://www.nature.com/articles/s41467-018-04757-w N2 - Phosphorylation-dependent YAP translocation is a well-known intracellular mechanism of the Hippo pathway; however, the molecular effectors governing YAP cytoplasmic translocation remains undefined. Recent findings indicate that oncogenic YAP paradoxically suppresses Wnt activity. Here, we show that Wnt scaffolding protein Dishevelled (DVL) is responsible for cytosolic translocation of phosphorylated YAP. Mutational inactivation of the nuclear export signal embedded in DVL leads to nuclear YAP retention, with an increase in TEAD transcriptional activity. DVL is also required for YAP subcellular localization induced by E-cadherin, a-catenin, or AMPK activation. Importantly, the nuclear-cytoplasmic trafficking is dependent on the p53-Lats2 or LKB1-AMPK tumor suppressor axes, which determine YAP phosphorylation status. In vivo and clinical data support that the loss of p53 or LKB1 relieves DVL-linked reciprocal inhibition between the Wnt and nuclear YAP activity. Our observations provide mechanistic insights into controlled proliferation coupled with epithelial polarity during development and human cancer. ER -
LEE, Y., N.H. KIM, E.S. CHO, J.H. YANG, Y.H. CHA, H.E. KANG, J.S. YUN, S.B. CHO, S.H. LEE, Petra PACLÍKOVÁ, Tomasz Witold RADASZKIEWICZ, Vítězslav BRYJA, C.G. KANG, Y.S. YUK, S.Y. CHA, S.Y. KIM, H.S. KIM a J.I. YOOK. Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner. \textit{Nature Communications}. London: Nature Publishing Group, 2018, roč.~9, č.~1, s.~1-16. ISSN~2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-018-04757-w.
|