| ESCHER, Beate I., Selim AIT-AISSA, Peter A. BEHNISCH, Werner BRACK, Francois BRION, Abraham BROUWER, Sebastian BUCHINGER, Sarah E. CRAWFORD, David DU PASQUIER, Timo HAMERS, Karina HETTWER, Klára HILSCHEROVÁ, Henner HOLLERT, Robert KASE, Cornelia KIENLE, Andrew J. TINDALL, Jochen TUERK, Ron VAN DER OOST, Etienne VERMEIRSSEN a Peta A. NEALE. Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive. Science of the Total Environment. Amsterdam: Elsevier Science, 2018, roč. 628-629, July, s. 748-765. ISSN 0048-9697. Dostupné z: https://dx.doi.org/10.1016/j.scitotenv.2018.01.340. |
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@article{1488438,
author = {Escher, Beate I. and AitandAissa, Selim and Behnisch, Peter A. and Brack, Werner and Brion, Francois and Brouwer, Abraham and Buchinger, Sebastian and Crawford, Sarah E. and Du Pasquier, David and Hamers, Timo and Hettwer, Karina and Hilscherová, Klára and Hollert, Henner and Kase, Robert and Kienle, Cornelia and Tindall, Andrew J. and Tuerk, Jochen and van der Oost, Ron and Vermeirssen, Etienne and Neale, Peta A.},
article_location = {Amsterdam},
article_number = {July},
doi = {http://dx.doi.org/10.1016/j.scitotenv.2018.01.340},
keywords = {Environmental quality standard; Water quality monitoring; Bioassay; Mixture toxicity; Effect-based trigger value; Reporter gene assay; Effect-based methods},
language = {eng},
issn = {0048-9697},
journal = {Science of the Total Environment},
title = {Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive},
url = {https://www.sciencedirect.com/science/article/pii/S0048969718303863?via%3Dihub},
volume = {628-629},
year = {2018}
}
TY - JOUR
ID - 1488438
AU - Escher, Beate I. - Ait-Aissa, Selim - Behnisch, Peter A. - Brack, Werner - Brion, Francois - Brouwer, Abraham - Buchinger, Sebastian - Crawford, Sarah E. - Du Pasquier, David - Hamers, Timo - Hettwer, Karina - Hilscherová, Klára - Hollert, Henner - Kase, Robert - Kienle, Cornelia - Tindall, Andrew J. - Tuerk, Jochen - van der Oost, Ron - Vermeirssen, Etienne - Neale, Peta A.
PY - 2018
TI - Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive
JF - Science of the Total Environment
VL - 628-629
IS - July
SP - 748-765
EP - 748-765
PB - Elsevier Science
SN - 00489697
KW - Environmental quality standard
KW - Water quality monitoring
KW - Bioassay
KW - Mixture toxicity
KW - Effect-based trigger value
KW - Reporter gene assay
KW - Effect-based methods
UR - https://www.sciencedirect.com/science/article/pii/S0048969718303863?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S0048969718303863?via%3Dihub
N2 - Effect-based methods including cell-based bioassays, reporter gene assays and whole-organism assays have been applied for decades in water quality monitoring and testing of enriched solid-phase extracts. There is no common EU-wide agreement on what level of bioassay response in water extracts is acceptable. At present, bioassay results are only benchmarked against each other but not against a consented measure of chemical water quality. The EU environmental quality standards (EQS) differentiate between acceptable and unacceptable surface water concentrations for individual chemicals but cannot capture the thousands of chemicals in water and their biological action as mixtures. We developed a method that reads across from existing EQS and includes additional mixture considerations with the goal that the derived effect-based trigger values (EBT) indicate acceptable risk for complex mixtures as they occur in surface water. Advantages and limitations of various approaches to read across from EQS are discussed and distilled to an algorithm that translates EQS into their corresponding bioanalytical equivalent concentrations (BEQ). The proposed EBT derivation method was applied to 48 in vitro bioassays with 32 of them having sufficient information to yield preliminary EBTs. To assess the practicability and robustness of the proposed approach, we compared the tentative EBTs with observed environmental effects. The proposed method only gives guidance on how to derive EBTs but does not propose final EBTs for implementation. The EBTs for some bioassays such as those for estrogenicity are already mature and could be implemented into regulation in the near future, while for others it will still take a few iterations until we can be confident of the power of the proposed EBTs to differentiate good from poor water quality with respect to chemical contamination.
ER -
ESCHER, Beate I., Selim AIT-AISSA, Peter A. BEHNISCH, Werner BRACK, Francois BRION, Abraham BROUWER, Sebastian BUCHINGER, Sarah E. CRAWFORD, David DU PASQUIER, Timo HAMERS, Karina HETTWER, Klára HILSCHEROVÁ, Henner HOLLERT, Robert KASE, Cornelia KIENLE, Andrew J. TINDALL, Jochen TUERK, Ron VAN DER OOST, Etienne VERMEIRSSEN a Peta A. NEALE. Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive. \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2018, roč.~628-629, July, s.~748-765. ISSN~0048-9697. Dostupné z: https://dx.doi.org/10.1016/j.scitotenv.2018.01.340.
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