Residual neuromuscular block in paediatric anaesthesia

J 2019

Residual neuromuscular block in paediatric anaesthesia

KLUČKA, Jozef, Martina KOSINOVÁ, Ivo KŘIKAVA, Roman ŠTOUDEK, Michaela ŤOUKÁLKOVÁ et. al.

Základní údaje

Originální název

Residual neuromuscular block in paediatric anaesthesia

Název česky

Reziduální nervosvalová blokáda v dětské anestezii

Autoři

KLUČKA, Jozef (703 Slovensko, domácí), Martina KOSINOVÁ (203 Česká republika, domácí), Ivo KŘIKAVA (203 Česká republika, domácí), Roman ŠTOUDEK (203 Česká republika, domácí), Michaela ŤOUKÁLKOVÁ (203 Česká republika, domácí) a Petr ŠTOURAČ (203 Česká republika, garant, domácí)

Vydání

British Journal of Anaesthesia, OXFORD, Oxford University Press, 2019, 0007-0912

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30223 Anaesthesiology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.880

Kód RIV

RIV/00216224:14110/19:00109048

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.bja.2018.10.001

UT WoS

000453927600001

Klíčová slova česky

nervosvalová blokáda; dětská anestezie; reziduální blokáda

Klíčová slova anglicky

neuromuscular blockade; paediatric anaesthesia; residual blockade

Štítky

14110322, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 5. 2020 08:26, Mgr. Tereza Miškechová

Anotace

ORIG CZ

V originále

Background: Residual neuromuscular blockade (RNB) in postoperative period is frequent (26-88%) and it is associated with negative impact on perioperative morbidity. The safety cut-off measured by accelerometry is currently defined as Train-of-four ratio (TOFr) >= 0.9. The primary outcome of the study was detect the incidence of RNB measured just prior extubation in the operating room (OR) (according to pragmatic trial design) and the secondary outcome was the incidence of the RNB in postanaethesia care unit (PACU). Methods: After Ethics Committee (10/2016) approval, paediatric patients (1.1.2017-31.12.2017) undergoing surgery in general anaesthesia with muscle relaxation were included in the study. The level of blockade was measured just prior to extubation in OR (patient eligible for extubation according to the anesthesiologist) and after arrival at PACU with acceleromtery – TOF-Watch®SX (Organon, Inc, West Orange, NJ). The mode for measurement was Train-of-four (TOF) and Train-of-four ratio (TOFr), in case of deep blockade Post-tetanic count (PTC). Data are described by descriptive analytic methods (mean, standard deviation -SD, median). Results: Overall, 291 patients were included in the study. The incidence of RNB in the OR was 48.2 % (95% CI: 42.4 54.1%, n=136) and the incidence of RNB in PACU was 26.9 % (95% CI: 19.5 35.3 %, n = 32). Active block reversal was administered in 23.3% (n=68) patients. Overall, 31.6% (87/275) patients were extubated with TOFr<0.9. Conclusion: Residual neuromuscular blockade in selected cohort of paediatric patients was frequent.

Česky

Práce popisuje incidenci reziduální nervosvalové blokády na operačním sále a na dospávacím pokoji u dětských pacientů.

Návaznosti

MUNI/A/1111/2018, interní kód MU

Název: Videolaryngoskopie vs. přímá laryngoskopie vliv na efektivitu intubace: randomizovaná kontrolovaná studie (Akronym: VidoeLarynx)

Investor: Masarykova univerzita, Videolaryngoskopie vs. přímá laryngoskopie vliv na efektivitu intubace: randomizovaná kontrolovaná studie, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

KLUČKA, Jozef, Martina KOSINOVÁ, Ivo KŘIKAVA, Roman ŠTOUDEK, Michaela ŤOUKÁLKOVÁ a Petr ŠTOURAČ. Residual neuromuscular block in paediatric anaesthesia. British Journal of Anaesthesia. OXFORD: Oxford University Press, 2019, roč. 122, č. 1, s. "E1"-"E2", 2 s. ISSN 0007-0912. Dostupné z: https://dx.doi.org/10.1016/j.bja.2018.10.001.

@article{1489907,
   author = {Klučka, Jozef and Kosinová, Martina and Křikava, Ivo and Štoudek, Roman and Ťoukálková, Michaela and Štourač, Petr},
   article_location = {OXFORD},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.bja.2018.10.001},
   keywords = {neuromuscular blockade; paediatric anaesthesia; residual blockade},
   language = {eng},
   issn = {0007-0912},
   journal = {British Journal of Anaesthesia},
   title = {Residual neuromuscular block in paediatric anaesthesia},
   url = {http://dx.doi.org/10.1016/j.bja.2018.10.001},
   volume = {122},
   year = {2019}
}

TY  - JOUR
ID  - 1489907
AU  - Klučka, Jozef - Kosinová, Martina - Křikava, Ivo - Štoudek, Roman - Ťoukálková, Michaela - Štourač, Petr
PY  - 2019
TI  - Residual neuromuscular block in paediatric anaesthesia
JF  - British Journal of Anaesthesia
VL  - 122
IS  - 1
SP  - "E1"-"E2"
EP  - "E1"-"E2"
PB  - Oxford University Press
SN  - 00070912
KW  - neuromuscular blockade
KW  - paediatric anaesthesia
KW  - residual blockade
UR  - http://dx.doi.org/10.1016/j.bja.2018.10.001
L2  - http://dx.doi.org/10.1016/j.bja.2018.10.001
N2  - Background: Residual neuromuscular blockade (RNB) in postoperative period is frequent (26-88%) and it is associated with negative impact on perioperative morbidity. The safety cut-off measured by accelerometry is currently defined as Train-of-four ratio (TOFr) >= 0.9. The primary outcome of the study was detect the incidence of RNB measured just prior extubation in the operating room (OR) (according to pragmatic trial design) and the secondary outcome was the incidence of the RNB in postanaethesia care unit (PACU). Methods: After Ethics Committee (10/2016) approval, paediatric patients (1.1.2017-31.12.2017) undergoing surgery in general anaesthesia with muscle relaxation were included in the study. The level of blockade was measured just prior to extubation in OR (patient eligible for extubation according to the anesthesiologist) and after arrival at PACU with acceleromtery – TOF-Watch®SX (Organon, Inc, West Orange, NJ). The mode for measurement was Train-of-four (TOF) and Train-of-four ratio (TOFr), in case of deep blockade Post-tetanic count (PTC). Data are described by descriptive analytic methods (mean, standard deviation -SD, median). Results: Overall, 291 patients were included in the study. The incidence of RNB in the OR was 48.2 % (95% CI: 42.4 54.1%, n=136) and the incidence of RNB in PACU was 26.9 % (95% CI: 19.5 35.3 %, n = 32). Active block reversal was administered in 23.3% (n=68) patients. Overall, 31.6% (87/275) patients were extubated with TOFr<0.9. Conclusion: Residual neuromuscular blockade in selected cohort of paediatric patients was frequent.
ER  -

KLUČKA, Jozef, Martina KOSINOVÁ, Ivo KŘIKAVA, Roman ŠTOUDEK, Michaela ŤOUKÁLKOVÁ a Petr ŠTOURAČ. Residual neuromuscular block in paediatric anaesthesia. \textit{British Journal of Anaesthesia}. OXFORD: Oxford University Press, 2019, roč.~122, č.~1, s.~''E1''-''E2'', 2 s. ISSN~0007-0912. Dostupné z: https://dx.doi.org/10.1016/j.bja.2018.10.001.

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