The gut microbiome and aquatic toxicology: An emerging concept
for environmental health

J 2018

The gut microbiome and aquatic toxicology: An emerging concept for environmental health

ADAMOVSKÝ, Ondřej; Amanda N. BUERGER; Alexis M. WORMINGTON; Naomi ECTOR; Robert J. GRIFFITT et al.

Základní údaje

Originální název

The gut microbiome and aquatic toxicology: An emerging concept for environmental health

Autoři

ADAMOVSKÝ, Ondřej; Amanda N. BUERGER; Alexis M. WORMINGTON; Naomi ECTOR; Robert J. GRIFFITT; Joseph H., Jr. BISESI a Christopher J. MARTYNIUK

Vydání

Environmental Toxicology and Chemistry, HOBOKEN, Wiley, 2018, 0730-7268

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.421

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/18:00106144

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

Gut dysbiosis; Short chain fatty acid; Inflammation; Adverse outcome pathway; Polycyclic aromatic hydrocarbon; Nanomaterial

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2019 21:13, Mgr. Michaela Hylsová, Ph.D.

Anotace

V originále

The microbiome plays an essential role in the health and onset of diseases in all animals, including humans. The microbiome has emerged as a central theme in environmental toxicology because microbes interact with the host immune system in addition to its role in chemical detoxification. Pathophysiological changes in the gastrointestinal tissue caused by ingested chemicals and metabolites generated from microbial biodegradation can lead to systemic adverse effects. The present critical review dissects what we know about the impacts of environmental contaminants on the microbiome of aquatic species, with special emphasis on the gut microbiome. We highlight some of the known major gut epithelium proteins in vertebrate hosts that are targets for chemical perturbation, proteins that also directly cross-talk with the microbiome. These proteins may act as molecular initiators for altered gut function, and we propose a general framework for an adverse outcome pathway that considers gut dysbiosis as a major contributing factor to adverse apical endpoints. We present 2 case studies, nanomaterials and hydrocarbons, with special emphasis on the Deepwater Horizon oil spill, to illustrate how investigations into the microbiome can improve understanding of adverse outcomes. Lastly, we present strategies to functionally relate chemical-induced gut dysbiosis with adverse outcomes because this is required to demonstrate cause-effect relationships. Further investigations into the toxicant-microbiome relationship may prove to be a major breakthrough for improving animal and human health. Environ Toxicol Chem 2018;37:2758-2775.

Návaznosti

CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MU

Název: RECETOX RI - OP VVV (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, RECETOX RI - OP VVV, PO 1 Posilování kapacit pro kvalitní výzkum

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

707241, interní kód MU

Název: Environmental chemicals as obesogens (Akronym: OBESOGENS)

Investor: Evropská unie, Environmental chemicals as obesogens, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

Citovat

ADAMOVSKÝ, Ondřej; Amanda N. BUERGER; Alexis M. WORMINGTON; Naomi ECTOR; Robert J. GRIFFITT; Joseph H., Jr. BISESI a Christopher J. MARTYNIUK. The gut microbiome and aquatic toxicology: An emerging concept for environmental health. Environmental Toxicology and Chemistry. HOBOKEN: Wiley, 2018, roč. 37, č. 11, s. 2758-2775. ISSN 0730-7268. Dostupné z: https://doi.org/10.1002/etc.4249.

@article{1495620,
   author = {Adamovský, Ondřej and Buerger, Amanda N. and Wormington, Alexis M. and Ector, Naomi and Griffitt, Robert J. and Bisesi, Joseph H., Jr. and Martyniuk, Christopher J.},
   article_location = {HOBOKEN},
   article_number = {11},
   doi = {https://doi.org/10.1002/etc.4249},
   keywords = {Gut dysbiosis; Short chain fatty acid; Inflammation; Adverse outcome pathway; Polycyclic aromatic hydrocarbon; Nanomaterial},
   language = {eng},
   issn = {0730-7268},
   journal = {Environmental Toxicology and Chemistry},
   title = {The gut microbiome and aquatic toxicology: An emerging concept for environmental health},
   url = {https://setac.onlinelibrary.wiley.com/doi/full/10.1002/etc.4249},
   volume = {37},
   year = {2018}
}

TY  - JOUR
ID  - 1495620
AU  - Adamovský, Ondřej - Buerger, Amanda N. - Wormington, Alexis M. - Ector, Naomi - Griffitt, Robert J. - Bisesi, Joseph H., Jr. - Martyniuk, Christopher J.
PY  - 2018
TI  - The gut microbiome and aquatic toxicology: An emerging concept for environmental health
JF  - Environmental Toxicology and Chemistry
VL  - 37
IS  - 11
SP  - 2758-2775
EP  - 2758-2775
PB  - Wiley
SN  - 07307268
KW  - Gut dysbiosis
KW  - Short chain fatty acid
KW  - Inflammation
KW  - Adverse outcome pathway
KW  - Polycyclic aromatic hydrocarbon
KW  - Nanomaterial
UR  - https://setac.onlinelibrary.wiley.com/doi/full/10.1002/etc.4249
L2  - https://setac.onlinelibrary.wiley.com/doi/full/10.1002/etc.4249
N2  - The microbiome plays an essential role in the health and onset of diseases in all animals, including humans. The microbiome has emerged as a central theme in environmental toxicology because microbes interact with the host immune system in addition to its role in chemical detoxification. Pathophysiological changes in the gastrointestinal tissue caused by ingested chemicals and metabolites generated from microbial biodegradation can lead to systemic adverse effects. The present critical review dissects what we know about the impacts of environmental contaminants on the microbiome of aquatic species, with special emphasis on the gut microbiome. We highlight some of the known major gut epithelium proteins in vertebrate hosts that are targets for chemical perturbation, proteins that also directly cross-talk with the microbiome. These proteins may act as molecular initiators for altered gut function, and we propose a general framework for an adverse outcome pathway that considers gut dysbiosis as a major contributing factor to adverse apical endpoints. We present 2 case studies, nanomaterials and hydrocarbons, with special emphasis on the Deepwater Horizon oil spill, to illustrate how investigations into the microbiome can improve understanding of adverse outcomes. Lastly, we present strategies to functionally relate chemical-induced gut dysbiosis with adverse outcomes because this is required to demonstrate cause-effect relationships. Further investigations into the toxicant-microbiome relationship may prove to be a major breakthrough for improving animal and human health. Environ Toxicol Chem 2018;37:2758-2775.
ER  -

ADAMOVSKÝ, Ondřej; Amanda N. BUERGER; Alexis M. WORMINGTON; Naomi ECTOR; Robert J. GRIFFITT; Joseph H., Jr. BISESI a Christopher J. MARTYNIUK. The gut microbiome and aquatic toxicology: An emerging concept for environmental health. \textit{Environmental Toxicology and Chemistry}. HOBOKEN: Wiley, 2018, roč.~37, č.~11, s.~2758-2775. ISSN~0730-7268. Dostupné z: https://doi.org/10.1002/etc.4249.

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