Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese
Central-European Population

J 2018

Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population

HOŘÁK, Martin, Daniela KURUCZOVÁ, Filip ZLÁMAL, Josef TOMANDL, Julie DOBROVOLNÁ et. al.

Základní údaje

Originální název

Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population

Autoři

HOŘÁK, Martin (203 Česká republika, garant, domácí), Daniela KURUCZOVÁ (703 Slovensko, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí) a Julie DOBROVOLNÁ (203 Česká republika)

Vydání

Disease Markers, London, Hindawi Publishing Corporation, 2018, 0278-0240

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30109 Pathology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.761

Kód RIV

RIV/00216224:14110/18:00106292

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1155/2018/4140815

UT WoS

000451854900001

Klíčová slova anglicky

Follistatin-like 1

Štítky

14110512, 14110518, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 3. 2019 10:31, Soňa Böhmová

Anotace

V originále

Follistatin-like 1 (FSTL1) is a secreted adipomyokine with a possible link to obesity; however, its connection to extreme obesity currently remains unknown. In order to analyze such association for the very first time, we employed a unique cohort of morbidly and super obese individuals with a mean BMI of 44.77 kg/m(2) and measured the levels of circulating FSTL1. We explored the 3' UTR of FSTL1 to locate a genetic variant which impairs microRNA binding. We located and investigated such SNP (rs1057231) in relation to the FSTL1 protein level, obesity status, and other body composition parameters. We observed a significant decline in FSTL1 level in obese subjects in comparison to nonobese ones. The evaluated SNP was found to correlate with FSTL1 only in nonobese subjects. The presented results were not affected by sex since both males and females expressed FSTL1 equally. We suggest that the FSTL1 decrease observed in extremely obese subjects is a result of adipogenesis reduction accompanied by a senescence of preadipocytes which otherwise willingly express FSTL1, increased adipocyte apoptosis, and epigenetic FSTL1 silencing.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

HOŘÁK, Martin, Daniela KURUCZOVÁ, Filip ZLÁMAL, Josef TOMANDL a Julie DOBROVOLNÁ. Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population. Disease Markers. London: Hindawi Publishing Corporation, 2018, roč. 2018, č. 4140815, s. 1-7. ISSN 0278-0240. Dostupné z: https://dx.doi.org/10.1155/2018/4140815.

@article{1499640,
   author = {Hořák, Martin and Kuruczová, Daniela and Zlámal, Filip and Tomandl, Josef and Dobrovolná, Julie},
   article_location = {London},
   article_number = {4140815},
   doi = {http://dx.doi.org/10.1155/2018/4140815},
   keywords = {Follistatin-like 1},
   language = {eng},
   issn = {0278-0240},
   journal = {Disease Markers},
   title = {Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population},
   volume = {2018},
   year = {2018}
}

TY  - JOUR
ID  - 1499640
AU  - Hořák, Martin - Kuruczová, Daniela - Zlámal, Filip - Tomandl, Josef - Dobrovolná, Julie
PY  - 2018
TI  - Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population
JF  - Disease Markers
VL  - 2018
IS  - 4140815
SP  - 1-7
EP  - 1-7
PB  - Hindawi Publishing Corporation
SN  - 02780240
KW  - Follistatin-like 1
N2  - Follistatin-like 1 (FSTL1) is a secreted adipomyokine with a possible link to obesity; however, its connection to extreme obesity currently remains unknown. In order to analyze such association for the very first time, we employed a unique cohort of morbidly and super obese individuals with a mean BMI of 44.77 kg/m(2) and measured the levels of circulating FSTL1. We explored the 3' UTR of FSTL1 to locate a genetic variant which impairs microRNA binding. We located and investigated such SNP (rs1057231) in relation to the FSTL1 protein level, obesity status, and other body composition parameters. We observed a significant decline in FSTL1 level in obese subjects in comparison to nonobese ones. The evaluated SNP was found to correlate with FSTL1 only in nonobese subjects. The presented results were not affected by sex since both males and females expressed FSTL1 equally. We suggest that the FSTL1 decrease observed in extremely obese subjects is a result of adipogenesis reduction accompanied by a senescence of preadipocytes which otherwise willingly express FSTL1, increased adipocyte apoptosis, and epigenetic FSTL1 silencing.
ER  -

HOŘÁK, Martin, Daniela KURUCZOVÁ, Filip ZLÁMAL, Josef TOMANDL a Julie DOBROVOLNÁ. Follistatin-Like 1 Is Downregulated in Morbidly and Super Obese Central-European Population. \textit{Disease Markers}. London: Hindawi Publishing Corporation, 2018, roč.~2018, č.~4140815, s.~1-7. ISSN~0278-0240. Dostupné z: https://dx.doi.org/10.1155/2018/4140815.

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