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@article{1502196,
author = {Gupta, Janesh and Chodankar, Rohan and Baev, Oleg and Bahlmann, Franz and Brega, Eugen and Gala, Anisha and Hellmeyer, Lars and Hruban, Lukáš and Maier, Josefine and Mehta, Priyanka and Murthy, Amitasrigowri and Ritter, Melanie and Saad, Antonio and Shmakov, Roman and Suneja, Amita and Zahumensky, Jozef and Gdovinova, Daniela},
article_location = {AMSTERDAM},
article_number = {OCT 2018},
doi = {http://dx.doi.org/10.1016/j.ejogrb.2018.08.004},
keywords = {Cervical ripening; Dilapan-S; Induction of labour; Synthetic osmotic dilators; Pregnancy; Birth},
language = {eng},
issn = {0301-2115},
journal = {EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY},
title = {Synthetic osmotic dilators in the induction of labour-An international multicentre observational study},
volume = {229},
year = {2018}
}
TY - JOUR
ID - 1502196
AU - Gupta, Janesh - Chodankar, Rohan - Baev, Oleg - Bahlmann, Franz - Brega, Eugen - Gala, Anisha - Hellmeyer, Lars - Hruban, Lukáš - Maier, Josefine - Mehta, Priyanka - Murthy, Amitasrigowri - Ritter, Melanie - Saad, Antonio - Shmakov, Roman - Suneja, Amita - Zahumensky, Jozef - Gdovinova, Daniela
PY - 2018
TI - Synthetic osmotic dilators in the induction of labour-An international multicentre observational study
JF - EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
VL - 229
IS - OCT 2018
SP - 70-75
EP - 70-75
PB - ELSEVIER SCIENCE BV
SN - 03012115
KW - Cervical ripening
KW - Dilapan-S
KW - Induction of labour
KW - Synthetic osmotic dilators
KW - Pregnancy
KW - Birth
N2 - Introduction: To evaluate the effects of synthetic osmotic dilators (Dilapan-S/Dilasoft) in women who required induction of labour in a large prospective multicentre international observational study. Materials and methods: Primary outcomes were duration of Dilapan-S/Dilasoft insertion (hours), total induction - delivery interval (hours) and the rate of vaginal deliveries within 24h (%). Secondary outcomes were the number of dilators inserted, Bishop score increase after extraction of Dilapan-S/Dilasoft, complications during induction (uterine contractions, uterine tachysystole and hyperstimulation, effect on the fetus) and post induction (infections and neonatal outcomes), agents / procedures used for subsequent induction of labour, immediate rate of spontaneous labours following cervical ripening period, rate of spontaneous vaginal deliveries, rate of instrumental vaginal deliveries and caesarean sections. RESULTS: Total of 543 women were recruited across 11 study sites, of which, 444 women were eligible for analysis. With Dilapan-S/Dilasoft use of <12 h (n =188) the overall vaginal delivery rate was 76.6% with 45.7% of these births occurring within 24 h, 66% within 36 h and 75.5% within 48 h from insertion of Dilapan-S/Dilasoft. The mean insertion-delivery interval for this group was 24.3(+/- 10.4) hours. With Dilapan-S/Dilasoft use of >12 h (n = 256), the overall vaginal delivery rate was 64.8%, with 16% of these births occurring within 24 h, 48.4% within 36 h and 54.7% within 48 h from insertion of Dilapan-S/Dilasoft. The mean insertion-delivery interval for this group was 39.1(+/- 29.2) hours. The mean gain in the Bishops score was +3.6(+/- 2.3). The mean number of Dilapan-S/Dilasoft dilators used was 3.8 (+/- 1.1). The overall rate of caesarean section was 30.1%. The overall complication rate was low including infection risk. No adverse neonatal outcome was attributable to the use of Dilapan-S/Dilaso Conclusion: Dilapan-S/Dilasoft are safe and effective methods for cervical ripening. Their use is associated with low maternal and neonatal complication rates. Future research should aim at level clinical trials comparing Dilapan-S to other mechanical or pharmacological cervical ripening agents. (C) 2018 Elsevier B.V. All rights reserved.
ER -
GUPTA, Janesh, Rohan CHODANKAR, Oleg BAEV, Franz BAHLMANN, Eugen BREGA, Anisha GALA, Lars HELLMEYER, Lukáš HRUBAN, Josefine MAIER, Priyanka MEHTA, Amitasrigowri MURTHY, Melanie RITTER, Antonio SAAD, Roman SHMAKOV, Amita SUNEJA, Jozef ZAHUMENSKY a Daniela GDOVINOVA. Synthetic osmotic dilators in the induction of labour-An international multicentre observational study. \textit{EUROPEAN JOURNAL OF OBSTETRICS \&{}amp; GYNECOLOGY AND REPRODUCTIVE BIOLOGY}. AMSTERDAM: ELSEVIER SCIENCE BV, 2018, roč.~229, OCT 2018, s.~70-75. ISSN~0301-2115. Dostupné z: https://dx.doi.org/10.1016/j.ejogrb.2018.08.004.
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