| FIALA, L., Petr BOB a J. RABOCH. Oncological markers CA-125, CA 19-9 and endometriosis. Medicine. Philadelphia: Lippincott Williams & Wilkins, 2018, roč. 97, č. 51, s. 13759-13761. ISSN 0025-7974. Dostupné z: https://dx.doi.org/10.1097/MD.0000000000013759. |
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@article{1505283,
author = {Fiala, L. and Bob, Petr and Raboch, J.},
article_location = {Philadelphia},
article_number = {51},
doi = {http://dx.doi.org/10.1097/MD.0000000000013759},
keywords = {CA 19-9; CA-125; dehydroepiandrosterone sulfate; endometriosis},
language = {eng},
issn = {0025-7974},
journal = {Medicine},
title = {Oncological markers CA-125, CA 19-9 and endometriosis},
volume = {97},
year = {2018}
}
TY - JOUR
ID - 1505283
AU - Fiala, L. - Bob, Petr - Raboch, J.
PY - 2018
TI - Oncological markers CA-125, CA 19-9 and endometriosis
JF - Medicine
VL - 97
IS - 51
SP - 13759
EP - 13759
PB - Lippincott Williams & Wilkins
SN - 00257974
KW - CA 19-9
KW - CA-125
KW - dehydroepiandrosterone sulfate
KW - endometriosis
N2 - The endometrium tissue is functionally androgen related which plays an important role in women's fertility regulation. In addition recent findings show that endometrium related pathology is closely linked to disrupted androgen biosynthesis and associated regulatory functions. These findings also suggest that androgens might play an important role in endometrium related cancer pathology with significant implications for treatment. Based on these findings, we have assessed 50 female outpatients with endometriosis and the clinical investigations were focused on biochemical serum analysis of DHEAS, oncological markers CA-125 and CA 19-9, estradiol, thyreothropic hormone. and prolactin. The results show significant Spearman correlations of CA-125 and CA 19-9 with dehydroepiandrosterone-DHEA-S (R=0.52 resp. R=0.49). This result represents 1st reported finding documenting androgen related increase of CA-125 and CA 19-9 levels as significant markers of endometrium pathology and it is possible to assume that these potential biomarkers could have clinical importance with respect to timely diagnosis.
ER -
FIALA, L., Petr BOB a J. RABOCH. Oncological markers CA-125, CA 19-9 and endometriosis. \textit{Medicine}. Philadelphia: Lippincott Williams \&{} Wilkins, 2018, roč.~97, č.~51, s.~13759-13761. ISSN~0025-7974. Dostupné z: https://dx.doi.org/10.1097/MD.0000000000013759.
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