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@article{1505759, author = {Tseliou, Fotini and Pappas, Periklis and Spyrou, Konstantinos and Hrbáč, Jan and Prodromidis, Mamas}, article_location = {Oxford}, article_number = {1 May 2019}, doi = {http://dx.doi.org/10.1016/j.bios.2019.03.001}, keywords = {Flunitrazepam; Rohypnol; Drug-facilitated sexual assault; Date-rape drugs; Screen-printed sparked electrodes; Point-of-need voltammetric sensors}, language = {eng}, issn = {0956-5663}, journal = {Biosensors and Bioelectronics}, title = {Lab-on-a-screen-printed electrochemical cell for drop-volume voltammetric screening of flunitrazepam in untreated, undiluted alcoholic and soft drinks}, url = {https://www.sciencedirect.com/science/article/pii/S0956566319301757}, volume = {132}, year = {2019} }
TY - JOUR ID - 1505759 AU - Tseliou, Fotini - Pappas, Periklis - Spyrou, Konstantinos - Hrbáč, Jan - Prodromidis, Mamas PY - 2019 TI - Lab-on-a-screen-printed electrochemical cell for drop-volume voltammetric screening of flunitrazepam in untreated, undiluted alcoholic and soft drinks JF - Biosensors and Bioelectronics VL - 132 IS - 1 May 2019 SP - 136-142 EP - 136-142 PB - Elsevier SN - 09565663 KW - Flunitrazepam KW - Rohypnol KW - Drug-facilitated sexual assault KW - Date-rape drugs KW - Screen-printed sparked electrodes KW - Point-of-need voltammetric sensors UR - https://www.sciencedirect.com/science/article/pii/S0956566319301757 L2 - https://www.sciencedirect.com/science/article/pii/S0956566319301757 N2 - Flunitrazepam, also known as “Rohypnol” or “Rophy” among other trade and street names, is an extremely potent benzodiazepine that is prescribed to treat severe insomnia. Due to these attributes, flunitrazepam, when is surreptitiously administered to an alcoholic or soft drink, is associated with “drug-facilitated sexual assault”. We report here for the first time, a low cost lab-on-a-screen-printed electrochemical cell (SPC) based on iron-sparked graphite working electrode modified with glucose oxidase (GOx) and glucose hydrogel droplets (GluHD) for the detection of flunitrazepam. Iron-spark modification increases the response of the sensor by ca. 3-fold compared with that of the plain electrode, while an in situ deoxygenation process, based on GOx-glucose enzyme reaction, depletes dissolved oxygen. As a result, the method enables interference free voltammetric measurements of the electro reduction of the nitro group of flunitrazepam at ca. -0.71 to -0.78 V vs. Ag printed pseudo reference electrode depending on the sample's matrix, and the detection of the drug at the sub-millimolar level. GOx/GluHD-FeSPC was directly applied to the drop-volume (~60 uL) detection of flunitrazepam to a wide range of untreated and undiluted spiked samples (Pepsi cola, Vodka, Whisky, Tequila, Gin, and Rum) of different acidity (pH 2.3–8.4), and alcohol content up to 40% v/v. Data demonstrate the excellent performance of the sensor for point-of-need screening of flunitrazepam and suggest that GOx/GluHD-FeSPC holds promise as an effective analytical tool to prevent phenomena of covert drug administration. ER -
TSELIOU, Fotini, Periklis PAPPAS, Konstantinos SPYROU, Jan HRBÁČ a Mamas PRODROMIDIS. Lab-on-a-screen-printed electrochemical cell for drop-volume voltammetric screening of flunitrazepam in untreated, undiluted alcoholic and soft drinks. \textit{Biosensors and Bioelectronics}. Oxford: Elsevier, roč.~132, 1 May 2019, s.~136-142. ISSN~0956-5663. doi:10.1016/j.bios.2019.03.001. 2019.
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