Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some ...

@article{1506123,
   author = {Kastriti, M.E. and Kameneva, P. and Kamenev, D. and Dyachuk, V. and Furlan, A. and Hampl, Marek and Memic, F. and Marklund, U. and Lallemend, F. and Hadjab, S. and CalvoandEnrique, L. and Ernfors, P. and Fried, K. and Adameyko, Igor},
   article_location = {Lausanne},
   article_number = {6},
   doi = {http://dx.doi.org/10.3389/fnmol.2019.00006},
   keywords = {Zuckerkandl organ; extra-adrenal chromaffin cells; posterior trunk sympathetic ganglia; para-aortic sympathetic ganglia; catecholamines; Schwann cell precursors},
   language = {eng},
   issn = {1662-5099},
   journal = {Frontiers in Molecular Neuroscience},
   title = {Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia},
   url = {https://www.frontiersin.org/articles/10.3389/fnmol.2019.00006/full},
   volume = {12},
   year = {2019}
}

TY  - JOUR
ID  - 1506123
AU  - Kastriti, M.E. - Kameneva, P. - Kamenev, D. - Dyachuk, V. - Furlan, A. - Hampl, Marek - Memic, F. - Marklund, U. - Lallemend, F. - Hadjab, S. - Calvo-Enrique, L. - Ernfors, P. - Fried, K. - Adameyko, Igor
PY  - 2019
TI  - Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia
JF  - Frontiers in Molecular Neuroscience
VL  - 12
IS  - 6
SP  - 1-17
EP  - 1-17
PB  - Frontiers Research Foundation
SN  - 16625099
KW  - Zuckerkandl organ
KW  - extra-adrenal chromaffin cells
KW  - posterior trunk sympathetic ganglia
KW  - para-aortic sympathetic ganglia
KW  - catecholamines
KW  - Schwann cell precursors
UR  - https://www.frontiersin.org/articles/10.3389/fnmol.2019.00006/full
L2  - https://www.frontiersin.org/articles/10.3389/fnmol.2019.00006/full
N2  - In humans, neurosecretory chromaffin cells control a number of important bodily functions, including those related to stress response. Chromaffin cells appear as a distinct cell type at the beginning of midgestation and are the main cellular source of adrenalin and noradrenalin released into the blood stream. In mammals, two different chromaffin organs emerge at a close distance to each other, the adrenal gland and Zuckerkandl organ (ZO). These two structures are found in close proximity to the kidneys and dorsal aorta, in a region where paraganglioma, pheochromocytoma and neuroblastoma originate in the majority of clinical cases. Recent studies showed that the chromaffin cells comprising the adrenal medulla are largely derived from nerve-associated multipotent Schwann cell precursors (SCPs) arriving at the adrenal anlage with the preganglionic nerve fibers, whereas the migratory neural crest cells provide only minor contribution. However, the embryonic origin of the ZO, which differs from the adrenal medulla in a number of aspects, has not been studied in detail. The ZO is composed of chromaffin cells in direct contact with the dorsal aorta and the intraperitoneal cavity and disappears through an autophagy-mediated mechanism after birth. In contrast, the adrenal medulla remains throughout the entire life and furthermore, is covered by the adrenal cortex. Using a combination of lineage tracing strategies with nerve- and cell type-specific ablations, we reveal that the ZO is largely SCP-derived and forms in synchrony with progressively increasing innervation. Moreover, the ZO develops hand-in-hand with the adjacent sympathetic ganglia that coalesce around the dorsal aorta. Finally, we were able to provide evidence for a SCP-contribution to a small but significant proportion of sympathetic neurons of the posterior paraganglia. Thus, this cellular source complements the neural crest, which acts as a main source of sympathetic neurons. Our discovery of a nerve-dependent origin of chromaffin cells and some sympathoblasts may help to understand the origin of pheochromocytoma, paraganglioma and neuroblastoma, all of which are currently thought to be derived from the neural crest or committed sympathoadrenal precursors.
ER  - 

KASTRITI, M.E., P. KAMENEVA, D. KAMENEV, V. DYACHUK, A. FURLAN, Marek HAMPL, F. MEMIC, U. MARKLUND, F. LALLEMEND, S. HADJAB, L. CALVO-ENRIQUE, P. ERNFORS, K. FRIED a Igor ADAMEYKO. Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia. \textit{Frontiers in Molecular Neuroscience}. Lausanne: Frontiers Research Foundation, 2019, roč.~12, č.~6, s.~1-17. ISSN~1662-5099. Dostupné z: https://dx.doi.org/10.3389/fnmol.2019.00006.