Developmental origins of depression-related white matter
properties: Findings from a prenatal birth cohort

J 2019

Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort

MAREČKOVÁ, Klára, A. KLASNJA, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, T. PAUS et. al.

Základní údaje

Originální název

Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort

Autoři

MAREČKOVÁ, Klára (203 Česká republika, garant, domácí), A. KLASNJA (124 Kanada), Lenka ANDRÝSKOVÁ (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, domácí) a T. PAUS (124 Kanada)

Vydání

Human Brain mapping, USA, WILEY, 2019, 1065-9471

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.421

Kód RIV

RIV/00216224:14740/19:00109323

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1002/hbm.24435

UT WoS

000459470400008

Klíčová slova anglicky

adolescence; cohort studies; depression; diffusion tensor imaging; life stress; prenatal development; white matter

Štítky

CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 8. 10. 2024 08:24, Ing. Jana Kuchtová

Anotace

V originále

Depression is the leading cause of years lost due to disability worldwide. Still, the mechanisms underlying its development are not well understood. This study aimed to evaluate white-matter properties associated with depressive symptomatology in young adulthood and their developmental origins. Diffusion tensor imaging and assessment of depressive symptomatology were conducted in 128 young adults (47% male, age 23-24) from a prenatal birth cohort (European Longitudinal Study of Pregnancy and Childhood). For a subset of these individuals, the database included information on prenatal stress (n = 93) and depressive symptoms during adolescence (assessed repeatedly at age 15 and 19). Depressive symptoms in young adulthood were associated with lower fractional anisotropy in the left and right cingulum and higher fractional anisotropy in the right corticospinal tract and superior longitudinal fasciculus. Further analyses revealed that prenatal stress and depressive symptomatology during adolescence were independent predictors of altered white-matter properties in the cingulum in young adulthood. We conclude that typically developing young adults with more depressive symptoms already exhibit tract-specific alterations in white-matter properties and that prenatal stress and depressive symptomatology during adolescence might contribute to their development.

Návaznosti

EF16_013/0001761, projekt VaV

Název: RECETOX RI

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

MUNI/E/0566/2018, interní kód MU

Název: Developmental origins of depression-related white matter properties (Akronym: DeOrDe)

Investor: Masarykova univerzita, Developmental origins of depression-related white matter properties, Podpora zvýšení kvality vynikajících výsledků

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

Citovat

MAREČKOVÁ, Klára, A. KLASNJA, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL a T. PAUS. Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort. Human Brain mapping. USA: WILEY, 2019, roč. 40, č. 4, s. 1155-1163. ISSN 1065-9471. Dostupné z: https://dx.doi.org/10.1002/hbm.24435.

@article{1508837,
   author = {Marečková, Klára and Klasnja, A. and Andrýsková, Lenka and Brázdil, Milan and Paus, T.},
   article_location = {USA},
   article_number = {4},
   doi = {http://dx.doi.org/10.1002/hbm.24435},
   keywords = {adolescence; cohort studies; depression; diffusion tensor imaging; life stress; prenatal development; white matter},
   language = {eng},
   issn = {1065-9471},
   journal = {Human Brain mapping},
   title = {Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort},
   url = {https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.24435},
   volume = {40},
   year = {2019}
}

TY  - JOUR
ID  - 1508837
AU  - Marečková, Klára - Klasnja, A. - Andrýsková, Lenka - Brázdil, Milan - Paus, T.
PY  - 2019
TI  - Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort
JF  - Human Brain mapping
VL  - 40
IS  - 4
SP  - 1155-1163
EP  - 1155-1163
PB  - WILEY
SN  - 10659471
KW  - adolescence
KW  - cohort studies
KW  - depression
KW  - diffusion tensor imaging
KW  - life stress
KW  - prenatal development
KW  - white matter
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.24435
L2  - https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.24435
N2  - Depression is the leading cause of years lost due to disability worldwide. Still, the mechanisms underlying its development are not well understood. This study aimed to evaluate white-matter properties associated with depressive symptomatology in young adulthood and their developmental origins. Diffusion tensor imaging and assessment of depressive symptomatology were conducted in 128 young adults (47% male, age 23-24) from a prenatal birth cohort (European Longitudinal Study of Pregnancy and Childhood). For a subset of these individuals, the database included information on prenatal stress (n = 93) and depressive symptoms during adolescence (assessed repeatedly at age 15 and 19). Depressive symptoms in young adulthood were associated with lower fractional anisotropy in the left and right cingulum and higher fractional anisotropy in the right corticospinal tract and superior longitudinal fasciculus. Further analyses revealed that prenatal stress and depressive symptomatology during adolescence were independent predictors of altered white-matter properties in the cingulum in young adulthood. We conclude that typically developing young adults with more depressive symptoms already exhibit tract-specific alterations in white-matter properties and that prenatal stress and depressive symptomatology during adolescence might contribute to their development.
ER  -

MAREČKOVÁ, Klára, A. KLASNJA, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL a T. PAUS. Developmental origins of depression-related white matter properties: Findings from a prenatal birth cohort. \textit{Human Brain mapping}. USA: WILEY, 2019, roč.~40, č.~4, s.~1155-1163. ISSN~1065-9471. Dostupné z: https://dx.doi.org/10.1002/hbm.24435.

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