Correlation of tumor necrosis factor alpha, interleukin 6 and
interleukin 10 with blood pressure, risk of preeclampsia and
low birth weight in gestational diabetes

J 2019

Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes

ŽÁK, Petr a Miroslav SOUČEK

Základní údaje

Originální název

Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes

Název česky

Korelace tumor necrosis factor alpha, interleukinu-6, interleukinu-10 s krevním tlakem, rizikem preeklampsie a nizkou porodní hmotností

Autoři

ŽÁK, Petr (203 Česká republika, garant, domácí) a Miroslav SOUČEK (203 Česká republika, domácí)

Vydání

Physiological Research, Prague, AV ČR, Institute of Physiology, 2019, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.655

Kód RIV

RIV/00216224:14110/19:00109499

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.33549/physiolres.934002

UT WoS

000476830200006

Klíčová slova česky

cytokin IL-6; Il-10; TNF alpha

Klíčová slova anglicky

cytokine IL-6; Il-10; TNF alpha

Štítky

14110116, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 4. 2020 14:20, Mgr. Tereza Miškechová

Anotace

V originále

Several pathophysiological mechanisms have been proposed in the development of pregnancy complications, including endothelial dysfunction, an inflammatory pathway and oxidative stress. The aim of the present study was to evaluate the correlation between proinflammatory cytokines TNF-alpha, IL-6 and dual cytokine IL-10 in the mother's peripheral blood and systolic blood pressure, risk of preeclampsia and low birth weight in gestational diabetes (GDM). We observed 40 women with GDM divided into a gestational hypertension group (n=20) and comparison group (n=20) with normal blood pressure. We found a significant positive correlation between TNF-alpha; IL-6; IL-10 levels and systolic blood pressure (SBP) in the second trimester (p<0.001; p<0.001; p<0.001); the third trimester (p<0.001; p<0.001; p<0.05). We also proved correlations for diastolic blood pressure (DBP) during the second; third trimester (p<0.001; p<0.001; p<0.001); (p<0.001; p<0.001; p<0.0015). We demonstrated a statistically significant positive association between high TNF-alpha group and preeclampsia risk in the third trimester (p=0.04). We also determined the negative correlation in the second trimester between birth weight and TNF-alpha; IL-6, IL-10 levels (p<0.05; p<0.001; p<0.001). To conclude, our data highlight the importance of cytokines TNF-alpha, IL-6 and IL-10 in blood pressure regulation. In addition, high levels of TNF-alpha have been associated with increased risk of preeclampsia. We found a significant negative correlation between levels of TNF-alpha, IL-6, IL-10 and birth weight.

Citovat

ŽÁK, Petr a Miroslav SOUČEK. Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes. Physiological Research. Prague: AV ČR, Institute of Physiology, 2019, roč. 68, č. 3, s. 395-408. ISSN 0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934002.

@article{1523596,
   author = {Žák, Petr and Souček, Miroslav},
   article_location = {Prague},
   article_number = {3},
   doi = {http://dx.doi.org/10.33549/physiolres.934002},
   keywords = {cytokine IL-6; Il-10; TNF alpha},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes},
   url = {https://www.biomed.cas.cz/physiolres/pdf/prepress/934002.pdf},
   volume = {68},
   year = {2019}
}

TY  - JOUR
ID  - 1523596
AU  - Žák, Petr - Souček, Miroslav
PY  - 2019
TI  - Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes
JF  - Physiological Research
VL  - 68
IS  - 3
SP  - 395-408
EP  - 395-408
PB  - AV ČR, Institute of Physiology
SN  - 08628408
KW  - cytokine IL-6
KW  - Il-10
KW  - TNF alpha
UR  - https://www.biomed.cas.cz/physiolres/pdf/prepress/934002.pdf
L2  - https://www.biomed.cas.cz/physiolres/pdf/prepress/934002.pdf
N2  - Several pathophysiological mechanisms have been proposed in the development of pregnancy complications, including endothelial dysfunction, an inflammatory pathway and oxidative stress. The aim of the present study was to evaluate the correlation between proinflammatory cytokines TNF-alpha, IL-6 and dual cytokine IL-10 in the mother's peripheral blood and systolic blood pressure, risk of preeclampsia and low birth weight in gestational diabetes (GDM). We observed 40 women with GDM divided into a gestational hypertension group (n=20) and comparison group (n=20) with normal blood pressure. We found a significant positive correlation between TNF-alpha; IL-6; IL-10 levels and systolic blood pressure (SBP) in the second trimester (p<0.001; p<0.001; p<0.001); the third trimester (p<0.001; p<0.001; p<0.05). We also proved correlations for diastolic blood pressure (DBP) during the second; third trimester (p<0.001; p<0.001; p<0.001); (p<0.001; p<0.001; p<0.0015). We demonstrated a statistically significant positive association between high TNF-alpha group and preeclampsia risk in the third trimester (p=0.04). We also determined the negative correlation in the second trimester between birth weight and TNF-alpha; IL-6, IL-10 levels (p<0.05; p<0.001; p<0.001). To conclude, our data highlight the importance of cytokines TNF-alpha, IL-6 and IL-10 in blood pressure regulation. In addition, high levels of TNF-alpha have been associated with increased risk of preeclampsia. We found a significant negative correlation between levels of TNF-alpha, IL-6, IL-10 and birth weight.
ER  -

ŽÁK, Petr a Miroslav SOUČEK. Correlation of tumor necrosis factor alpha, interleukin 6 and interleukin 10 with blood pressure, risk of preeclampsia and low birth weight in gestational diabetes. \textit{Physiological Research}. Prague: AV ČR, Institute of Physiology, 2019, roč.~68, č.~3, s.~395-408. ISSN~0862-8408. Dostupné z: https://dx.doi.org/10.33549/physiolres.934002.

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