Safety of urgent endarterectomy in acute non-disabling stroke patients with symptomatic carotid artery stenosis: an international multicenter study

ROUSSOPOULOU, A.; G. TSIVGOULIS; C. KROGIAS; A. LAZARIS; K. MOULAKAKIS; G.S. GEORGIADIS; Robert MIKULÍK; J.D. KAKISIS; C. ZOMPOLA; S. FAISSNER; M. CHONDROGIANNI; C. LIANTINIOTI; T. HUMMEEL; A. SAFOURIS; P. MATSOT; K. VOUMVOURAKIS; M. LAZARIDES; G. GEROULAKOS a S.N. VASDEKIS. Safety of urgent endarterectomy in acute non-disabling stroke patients with symptomatic carotid artery stenosis: an international multicenter study. European Journal of Neurology. Oxford: Rapid Science Ltd., 2019, roč. 26, č. 4, s. 673-679. ISSN 1351-5101. Dostupné z: https://dx.doi.org/10.1111/ene.13876.

Základní údaje

Originální název

Safety of urgent endarterectomy in acute non-disabling stroke patients with symptomatic carotid artery stenosis: an international multicenter study

Autoři

ROUSSOPOULOU, A. (300 Řecko); G. TSIVGOULIS (300 Řecko, garant); C. KROGIAS (276 Německo); A. LAZARIS (300 Řecko); K. MOULAKAKIS (300 Řecko); G.S. GEORGIADIS (300 Řecko); Robert MIKULÍK (203 Česká republika, domácí); J.D. KAKISIS (300 Řecko); C. ZOMPOLA (300 Řecko); S. FAISSNER (300 Řecko); M. CHONDROGIANNI (300 Řecko); C. LIANTINIOTI (300 Řecko); T. HUMMEEL (276 Německo); A. SAFOURIS (300 Řecko); P. MATSOT (300 Řecko); K. VOUMVOURAKIS (300 Řecko); M. LAZARIDES (300 Řecko); G. GEROULAKOS (300 Řecko) a S.N. VASDEKIS (300 Řecko)

Vydání

European Journal of Neurology, Oxford, Rapid Science Ltd. 2019, 1351-5101

---

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.516

Kód RIV

RIV/00216224:14110/19:00109548

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/ene.13876

UT WoS

000460307300020

EID Scopus

2-s2.0-85059054181

Klíčová slova anglicky

carotid; endarterectomy; safety; stroke; TIA; urgent

Štítky

14110127, rivok

Příznaky

Mezinárodní význam, Recenzováno

---

Anotace

V originále

Background and purpose International recommendations advocate that carotid endarterectomy (CEA) should be performed within 2 weeks from the index event in symptomatic carotid artery stenosis (sCAS) patients. However, there are controversial data regarding the safety of CEA performed during the first 2 days of ictus. The aim of this international, multicenter study was to prospectively evaluate the safety of urgent (0-2 days) in comparison to early (3-14 days) CEA in patients with sCAS. Methods Consecutive patients with non-disabling (modified Rankin Scale scores <= 2) acute ischaemic stroke or transient ischaemic attack due to sCAS (>= 70%) underwent urgent or early CEA at five tertiary-care stroke centers during a 6-year period. The primary outcome events included stroke, myocardial infarction or death during the 30-day follow-up period. Results A total of 311 patients with sCAS underwent urgent (n = 63) or early (n = 248) CEA. The two groups did not differ in baseline characteristics with the exception of crescendo transient ischaemic attacks (21% in urgent vs. 7% in early CEA; P = 0.001). The 30-day rates of stroke did not differ (P = 0.333) between patients with urgent (7.9%; 95% confidence interval 3.1%-17.7%) and early (4.4%; 95% confidence interval 2.4%-7.9%) CEA. The mortality and myocardial infarction rates were similar between the two groups. The median length of hospitalization was shorter in urgent CEA [6 days (interquartile range 4-6) vs. 10 days (interquartile range 7-14); P Conclusions Our findings highlight that urgent CEA performed within 2 days from the index event is related to a non-significant increase in the risk of peri-procedural stroke. The safety of urgent CEA requires further evaluation in larger datasets.