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@article{1531402,
author = {Plutinský, Marek and Brat, Kristián and Svoboda, Michal and Zatloukal, Jaromir and Popelkova, Patricie and Koblizek, Vladimir},
article_location = {NEW YORK},
article_number = {2},
doi = {http://dx.doi.org/10.1007/s00408-019-00196-6},
keywords = {COPD; GOLD classification; Prognosis; Mortality},
language = {eng},
issn = {0341-2040},
journal = {LUNG},
title = {Prognostic Accuracy of Three COPD Classification Systems in Relation to Long-Term Mortality of COPD Patients: A Prospective Multicenter Study},
url = {http://dx.doi.org/10.1007/s00408-019-00196-6},
volume = {197},
year = {2019}
}
TY - JOUR
ID - 1531402
AU - Plutinský, Marek - Brat, Kristián - Svoboda, Michal - Zatloukal, Jaromir - Popelkova, Patricie - Koblizek, Vladimir
PY - 2019
TI - Prognostic Accuracy of Three COPD Classification Systems in Relation to Long-Term Mortality of COPD Patients: A Prospective Multicenter Study
JF - LUNG
VL - 197
IS - 2
SP - 173-179
EP - 173-179
PB - SPRINGER
SN - 03412040
KW - COPD
KW - GOLD classification
KW - Prognosis
KW - Mortality
UR - http://dx.doi.org/10.1007/s00408-019-00196-6
L2 - http://dx.doi.org/10.1007/s00408-019-00196-6
N2 - Recent research showed group B patients express higher mortality compared to group C patients when GOLD A-D grouping is used. We aimed to compare the prognostic accuracy of three GOLD classification systems, I-IV (pre-2011), A-D (2011-2016) and A-D (2017-present) in relation to mortality, exacerbation risk, quality of life (QoL) assessment and specific treatments use in a real-life COPD cohort. We used the data of 720 patients from the Czech Multicenter Research Database of COPD. Four-year mortality and time-to-exacerbation using the GOLD pre-2011, 2011-2016 and 2017-present classification schemes were assessed. Moreover, distribution of specific treatments use and QoL measures were analyzed. The GOLD I-IV classification system showed gradual increase in 4-year mortality across the stages (GOLD II 18.8%, III 28.5%, IV 38.7%) (p=0.001). Using the A-D 2011-2016 classification scheme, group C patients had lower mortality (16.7%) than group B (18.7%) (p=0.009). The A-D 2017-present classification showed higher mortality in group B (25.5%) compared to group C (20%) (p=0.05). For additional outcomes, the GOLD I-IV scheme showed highest match between the calculated 4-year exacerbation risk and QoL measures and GOLD stage/grouping. In terms of specific treatment distributions, various patterns for each GOLD classification system were observed with best match of GOLD 2017-present system to the layout of GOLD groups and categories. We conclude the GOLD I-IV classification system had the highest accuracy related to mortality, QoL measures and exacerbation risk prediction, while the A-D 2017-present scheme was most accurate within severity of symptoms prediction reflected also by more frequent specific treatments use.
ER -
PLUTINSKÝ, Marek, Kristián BRAT, Michal SVOBODA, Jaromir ZATLOUKAL, Patricie POPELKOVA a Vladimir KOBLIZEK. Prognostic Accuracy of Three COPD Classification Systems in Relation to Long-Term Mortality of COPD Patients: A Prospective Multicenter Study. \textit{LUNG}. NEW YORK: SPRINGER, 2019, roč.~197, č.~2, s.~173-179. ISSN~0341-2040. Dostupné z: https://dx.doi.org/10.1007/s00408-019-00196-6.
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