Lymphoproliferation, immunodeficiency and early-onset
inflammatory bowel disease associated with a novel mutation in
Caspase 8

J 2019

Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8

KANDEROVA, V.; H. GROMBIRIKOVA; I. ZENTSOVA; Kamila RÉBLOVÁ; A. KLOCPERK et. al.

Základní údaje

Originální název

Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8

Autoři

KANDEROVA, V.; H. GROMBIRIKOVA; I. ZENTSOVA; Kamila RÉBLOVÁ ; A. KLOCPERK; M. FEJTKOVA; M. BLOOMFIELD; B. RAVCUKOVA; T. KALINA; Tomáš FREIBERGER a A. SEDIVA

Vydání

Haematologica, PAVIA, FERRATA STORTI FOUNDATION, 2019, 0390-6078

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30205 Hematology

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.116

Kód RIV

RIV/00216224:14110/19:00108470

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.3324/haematol.2018.201673

UT WoS

000457454500009

EID Scopus

2-s2.0-85059265749

Klíčová slova anglicky

ACTIVATION

Štítky

14110114, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2020 08:49, Mgr. Tereza Miškechová

Anotace

V originále

Caspase-8 is a member of the aspartate-specific cysteine protease family that is typically synthetized as an inactive zymogen and activated upon an appropriate stimulus. Caspase-8 plays an essential role in apoptotic signal transduction from the death receptor. Recruitment of procaspase-8 into the death signaling complex leads to its dimerization, autoproteolytic cleavage and formation of a highly active heterotetramer. Caspase-8 subsequently activates caspase-3, thereby initiating the proteolytic pathway, and ultimately resulting in the apoptotic disassembly of the cell.1 Additionally, caspase-8 is also essential for various immune processes, such as lymphocyte activation, inflammasome regulation and cytokine production

Návaznosti

NV16-34414A, projekt VaV

Název: Určení genových oblastí náchylných ke vzniku mutací ovlivňujících sestřih mRNA

Citovat

KANDEROVA, V.; H. GROMBIRIKOVA; I. ZENTSOVA; Kamila RÉBLOVÁ; A. KLOCPERK; M. FEJTKOVA; M. BLOOMFIELD; B. RAVCUKOVA; T. KALINA; Tomáš FREIBERGER a A. SEDIVA. Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8. Haematologica. PAVIA: FERRATA STORTI FOUNDATION, 2019, roč. 104, č. 1, s. "E32"-"E34", 3 s. ISSN 0390-6078. Dostupné z: https://doi.org/10.3324/haematol.2018.201673.

@article{1531637,
   author = {Kanderova, V. and Grombirikova, H. and Zentsova, I. and Réblová, Kamila and Klocperk, A. and Fejtkova, M. and Bloomfield, M. and Ravcukova, B. and Kalina, T. and Freiberger, Tomáš and Sediva, A.},
   article_location = {PAVIA},
   article_number = {1},
   doi = {https://doi.org/10.3324/haematol.2018.201673},
   keywords = {ACTIVATION},
   language = {eng},
   issn = {0390-6078},
   journal = {Haematologica},
   title = {Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8},
   url = {http://www.haematologica.org/content/haematol/104/1/e32.full.pdf},
   volume = {104},
   year = {2019}
}

TY  - JOUR
ID  - 1531637
AU  - Kanderova, V. - Grombirikova, H. - Zentsova, I. - Réblová, Kamila - Klocperk, A. - Fejtkova, M. - Bloomfield, M. - Ravcukova, B. - Kalina, T. - Freiberger, Tomáš - Sediva, A.
PY  - 2019
TI  - Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8
JF  - Haematologica
VL  - 104
IS  - 1
SP  - "E32"-"E34"
EP  - "E32"-"E34"
PB  - FERRATA STORTI FOUNDATION
SN  - 03906078
KW  - ACTIVATION
UR  - http://www.haematologica.org/content/haematol/104/1/e32.full.pdf
L2  - http://www.haematologica.org/content/haematol/104/1/e32.full.pdf
N2  - Caspase-8 is a member of the aspartate-specific cysteine protease family that is typically synthetized as an inactive zymogen and activated upon an appropriate stimulus. Caspase-8 plays an essential role in apoptotic signal transduction from the death receptor. Recruitment of procaspase-8 into the death signaling complex leads to its dimerization, autoproteolytic cleavage and formation of a highly active heterotetramer. Caspase-8 subsequently activates caspase-3, thereby initiating the proteolytic pathway, and ultimately resulting in the apoptotic disassembly of the cell.1 Additionally, caspase-8 is also essential for various immune processes, such as lymphocyte activation, inflammasome regulation and cytokine production
ER  -

KANDEROVA, V.; H. GROMBIRIKOVA; I. ZENTSOVA; Kamila RÉBLOVÁ; A. KLOCPERK; M. FEJTKOVA; M. BLOOMFIELD; B. RAVCUKOVA; T. KALINA; Tomáš FREIBERGER a A. SEDIVA. Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8. \textit{Haematologica}. PAVIA: FERRATA STORTI FOUNDATION, 2019, roč.~104, č.~1, s.~''E32''-''E34'', 3 s. ISSN~0390-6078. Dostupné z: https://doi.org/10.3324/haematol.2018.201673.

Přehled o publikaci