Prenatal Stress, Mood, and Gray Matter Volume in Young
Adulthood

J 2019

Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood

MAREČKOVÁ, Klára, A. KLASNJA, Petra BENCÚROVÁ, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL et. al.

Základní údaje

Originální název

Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood

Autoři

MAREČKOVÁ, Klára (203 Česká republika, garant, domácí), A. KLASNJA (124 Kanada), Petra BENCÚROVÁ (703 Slovensko, domácí), Lenka ANDRÝSKOVÁ (203 Česká republika, domácí), Milan BRÁZDIL (203 Česká republika, domácí) a T. PAUS (124 Kanada)

Vydání

CEREBRAL CORTEX, CARY, OXFORD UNIV PRESS INC, 2019, 1047-3211

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.043

Kód RIV

RIV/00216224:14740/19:00109679

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1093/cercor/bhy030

UT WoS

000462494100025

Klíčová slova anglicky

European longitudinal study of pregnancy and childhood mood dysregulation; gray matter volume; magnetic resonance imaging; prenatal stress

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 3. 2020 21:49, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

This study aimed to determine whether prenatal stress, measured by the number of stressful life events during the first 20 weeks of pregnancy, might relate to mood dysregulation and altered brain structure in young adulthood. Participants included 93 young adults from a community-based birth cohort from the Czech Republic. Information on prenatal stress exposure was collected from their mothers in 1990-1992. Magnetic resonance imaging (MRI) and mood-related data were collected from the young adults in 2015. MRI analyses focused on overall gray matter (GM) volume and GM volume of cortical regions previously associated with major depression. Higher prenatal stress predicted more mood dysregulation, lower overall GM volume, and lower GM volume in mid-dorsolateral frontal cortex, anterior cingulate cortex, and precuneus in young adulthood. We observed no prenatal stress by sex interactions for any of the relations. We conclude that prenatal stress is an important risk factor that relates to worse mood states and altered brain structure in young adulthood irrespective of sex. Our results point to the importance and long-lasting effects of prenatal programming and suggest that offspring of mothers who went through substantial stress during pregnancy might benefit from early intervention that would reduce the odds of mental illness in later life.

Návaznosti

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

MAREČKOVÁ, Klára, A. KLASNJA, Petra BENCÚROVÁ, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL a T. PAUS. Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood. CEREBRAL CORTEX. CARY: OXFORD UNIV PRESS INC, 2019, roč. 29, č. 3, s. 1244-1250. ISSN 1047-3211. Dostupné z: https://dx.doi.org/10.1093/cercor/bhy030.

@article{1531776,
   author = {Marečková, Klára and Klasnja, A. and Bencúrová, Petra and Andrýsková, Lenka and Brázdil, Milan and Paus, T.},
   article_location = {CARY},
   article_number = {3},
   doi = {http://dx.doi.org/10.1093/cercor/bhy030},
   keywords = {European longitudinal study of pregnancy and childhood mood dysregulation; gray matter volume; magnetic resonance imaging; prenatal stress},
   language = {eng},
   issn = {1047-3211},
   journal = {CEREBRAL CORTEX},
   title = {Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood},
   url = {https://academic.oup.com/cercor/article-abstract/29/3/1244/4841691?redirectedFrom=fulltext},
   volume = {29},
   year = {2019}
}

TY  - JOUR
ID  - 1531776
AU  - Marečková, Klára - Klasnja, A. - Bencúrová, Petra - Andrýsková, Lenka - Brázdil, Milan - Paus, T.
PY  - 2019
TI  - Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood
JF  - CEREBRAL CORTEX
VL  - 29
IS  - 3
SP  - 1244-1250
EP  - 1244-1250
PB  - OXFORD UNIV PRESS INC
SN  - 10473211
KW  - European longitudinal study of pregnancy and childhood mood dysregulation
KW  - gray matter volume
KW  - magnetic resonance imaging
KW  - prenatal stress
UR  - https://academic.oup.com/cercor/article-abstract/29/3/1244/4841691?redirectedFrom=fulltext
L2  - https://academic.oup.com/cercor/article-abstract/29/3/1244/4841691?redirectedFrom=fulltext
N2  - This study aimed to determine whether prenatal stress, measured by the number of stressful life events during the first 20 weeks of pregnancy, might relate to mood dysregulation and altered brain structure in young adulthood. Participants included 93 young adults from a community-based birth cohort from the Czech Republic. Information on prenatal stress exposure was collected from their mothers in 1990-1992. Magnetic resonance imaging (MRI) and mood-related data were collected from the young adults in 2015. MRI analyses focused on overall gray matter (GM) volume and GM volume of cortical regions previously associated with major depression. Higher prenatal stress predicted more mood dysregulation, lower overall GM volume, and lower GM volume in mid-dorsolateral frontal cortex, anterior cingulate cortex, and precuneus in young adulthood. We observed no prenatal stress by sex interactions for any of the relations. We conclude that prenatal stress is an important risk factor that relates to worse mood states and altered brain structure in young adulthood irrespective of sex. Our results point to the importance and long-lasting effects of prenatal programming and suggest that offspring of mothers who went through substantial stress during pregnancy might benefit from early intervention that would reduce the odds of mental illness in later life.
ER  -

MAREČKOVÁ, Klára, A. KLASNJA, Petra BENCÚROVÁ, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL a T. PAUS. Prenatal Stress, Mood, and Gray Matter Volume in Young Adulthood. \textit{CEREBRAL CORTEX}. CARY: OXFORD UNIV PRESS INC, 2019, roč.~29, č.~3, s.~1244-1250. ISSN~1047-3211. Dostupné z: https://dx.doi.org/10.1093/cercor/bhy030.

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