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@article{1545967, author = {Abad, Etna and GarciaandMayea, Yoelsis and Mir, Cristina and Sebastian, David and Zorzano, Antonio and Potěšil, David and Zdráhal, Zbyněk and Lyakhovich, Alex and Lleonart, Matilde}, article_number = {2}, doi = {http://dx.doi.org/10.1074/mcp.RA118.001102}, keywords = {STEM-CELLS; DYSFUNCTION; AUTOPHAGY; HYDROXYCHLOROQUINE; TOXICITY; TARGET; GROWTH; ACID}, language = {eng}, issn = {1535-9476}, journal = {Molecular and Cellurar Proteomic}, title = {Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer}, url = {https://www.mcponline.org/content/18/2/231}, volume = {18}, year = {2019} }
TY - JOUR ID - 1545967 AU - Abad, Etna - Garcia-Mayea, Yoelsis - Mir, Cristina - Sebastian, David - Zorzano, Antonio - Potěšil, David - Zdráhal, Zbyněk - Lyakhovich, Alex - Lleonart, Matilde PY - 2019 TI - Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer JF - Molecular and Cellurar Proteomic VL - 18 IS - 2 SP - 231-244 EP - 231-244 PB - American Society for Biochemistry and Molecular Biology SN - 15359476 KW - STEM-CELLS KW - DYSFUNCTION KW - AUTOPHAGY KW - HYDROXYCHLOROQUINE KW - TOXICITY KW - TARGET KW - GROWTH KW - ACID UR - https://www.mcponline.org/content/18/2/231 L2 - https://www.mcponline.org/content/18/2/231 N2 - Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated that CSC and chemoresistant cells derived from triple negative breast cancer cells display an enrichment of up-and downregulated proteins from metabolic pathways that suggests their dependence on mitochondria for survival. Here, we selected antibiotics, in particular - linezolid, inhibiting translation of mitoribosomes and inducing mitochondrial dysfunction. We provided the first in vivo evidence demonstrating that linezolid suppressed tumor growth rate, accompanied by increased autophagy. In addition, our results revealed that bactericidal antibiotics used in combination with autophagy blocker decrease tumor growth. This study puts mitochondria in a spotlight for cancer therapy and places antibiotics as effective agents for eliminating CSC and resistant cells. ER -
ABAD, Etna, Yoelsis GARCIA-MAYEA, Cristina MIR, David SEBASTIAN, Antonio ZORZANO, David POTĚŠIL, Zbyněk ZDRÁHAL, Alex LYAKHOVICH a Matilde LLEONART. Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer. \textit{Molecular and Cellurar Proteomic}. American Society for Biochemistry and Molecular Biology, 2019, roč.~18, č.~2, s.~231-244. ISSN~1535-9476. Dostupné z: https://dx.doi.org/10.1074/mcp.RA118.001102.
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