J 2019

Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer

ABAD, Etna, Yoelsis GARCIA-MAYEA, Cristina MIR, David SEBASTIAN, Antonio ZORZANO et. al.

Basic information

Original name

Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer

Authors

ABAD, Etna (724 Spain), Yoelsis GARCIA-MAYEA (724 Spain), Cristina MIR (724 Spain), David SEBASTIAN (724 Spain), Antonio ZORZANO (724 Spain), David POTĚŠIL (203 Czech Republic, belonging to the institution), Zbyněk ZDRÁHAL (203 Czech Republic, guarantor, belonging to the institution), Alex LYAKHOVICH (724 Spain) and Matilde LLEONART (724 Spain)

Edition

Molecular and Cellurar Proteomic, American Society for Biochemistry and Molecular Biology, 2019, 1535-9476

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.870

RIV identification code

RIV/00216224:14740/19:00107512

Organization unit

Central European Institute of Technology

UT WoS

000457454000005

Keywords in English

STEM-CELLS; DYSFUNCTION; AUTOPHAGY; HYDROXYCHLOROQUINE; TOXICITY; TARGET; GROWTH; ACID

Tags

Tags

International impact, Reviewed
Změněno: 9/10/2024 14:06, Ing. Martina Blahová

Abstract

V originále

Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated that CSC and chemoresistant cells derived from triple negative breast cancer cells display an enrichment of up-and downregulated proteins from metabolic pathways that suggests their dependence on mitochondria for survival. Here, we selected antibiotics, in particular - linezolid, inhibiting translation of mitoribosomes and inducing mitochondrial dysfunction. We provided the first in vivo evidence demonstrating that linezolid suppressed tumor growth rate, accompanied by increased autophagy. In addition, our results revealed that bactericidal antibiotics used in combination with autophagy blocker decrease tumor growth. This study puts mitochondria in a spotlight for cancer therapy and places antibiotics as effective agents for eliminating CSC and resistant cells.

Links

GBP206/12/G151, research and development project
Name: Centrum nových přístupů k bioanalýze a molekulární diagnostice
LM2015043, research and development project
Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)
Investor: Ministry of Education, Youth and Sports of the CR
LQ1601, research and development project
Name: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
90043, large research infrastructures
Name: CIISB