Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based
Rotaxanes with Antimetastatic Properties

J 2019

Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties

SOJKA, Martin; Michaela FOJTŮ; Jindřiška FIALOVÁ; Michal MASAŘÍK; Marek NEČAS et. al.

Základní údaje

Originální název

Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties

Autoři

SOJKA, Martin; Michaela FOJTŮ; Jindřiška FIALOVÁ; Michal MASAŘÍK; Marek NEČAS a Radek MAREK

Vydání

Inorganic Chemistry, American Chemical Society, 2019, 0020-1669

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10402 Inorganic and nuclear chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

DOI: 10.1021/acs.inorgchem.9b01203

Impakt faktor

Impact factor: 4.825

Kód RIV

RIV/00216224:14740/19:00107525

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1021/acs.inorgchem.9b01203

UT WoS

000482173300049

EID Scopus

2-s2.0-85070643944

Klíčová slova anglicky

metallodrug;ruthenium;rotaxane;cucurbituril;anticancer;antimetastatic

Štítky

14110515, 14110518, CF NMR, CF SAXS, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 10. 2024 12:35, Ing. Marie Švancarová

Anotace

V originále

We report here the first coupling of Ru(II) units with cucurbit[6/7]uril-based pseudorotaxane ligands meant for biological application. The resulting ruthenium-capped rotaxanes were fully characterized, and a structure of one supramolecular system was determined by X-ray diffraction. Because the biological properties of Ru-based metallodrugs are tightly linked to the ligand-exchange processes, the effect of salt concentration on the hydrolysis of chlorides from the Ru(II) center was monitored by using 1H NMR spectroscopy. The biological activity of Ru(II)-based rotaxanes was evaluated for three selected mammalian breast cell lines, HBL-100, MCF-7, and MDA-MB-231. The antimetastatic activity of the assembled cationic Ru(II)-rotaxane systems, evaluated in migration assays against MCF-7 and MDA-MB-231 cell lines, is notably enhanced compared to that of RAPTA-C, a reference that was used. The indicated synergistic effect of combining Ru(II) with a pseudorotaxane unit opens a new direction in searching for anticancer supramolecular metallodrugs.

Návaznosti

GA15-09381S, projekt VaV

Název: Struktura a vlastnosti paramagnetických komplexů ruthenia pro návrh nových protirakovinných léčiv (Akronym: PARAMAG)

Investor: Grantová agentura ČR, Struktura a vlastnosti paramagnetických komplexů ruthenia pro návrh nových protirakovinných léčiv

GA18-05421S, projekt VaV

Název: Rozvoj paramagnetické NMR spektroskopie pro supramolekulární systémy (Akronym: SUPRAMAG)

Investor: Grantová agentura ČR, Rozvoj paramagnetické NMR spektroskopie pro supramolekulární systémy

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

90043, velká výzkumná infrastruktura

Název: CIISB

Přiložené soubory

IC19_58_10861_acs.inorgchem.9b01203.pdf

Požádat o autorskou verzi souboru

Citovat

SOJKA, Martin; Michaela FOJTŮ; Jindřiška FIALOVÁ; Michal MASAŘÍK; Marek NEČAS a Radek MAREK. Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties. Inorganic Chemistry. American Chemical Society, 2019, roč. 58, č. 16, s. 10861-10870, 12 s. ISSN 0020-1669. Dostupné z: https://doi.org/10.1021/acs.inorgchem.9b01203.

@article{1547498,
   author = {Sojka, Martin and Fojtů, Michaela and Fialová, Jindřiška and Masařík, Michal and Nečas, Marek and Marek, Radek},
   article_number = {16},
   doi = {https://doi.org/10.1021/acs.inorgchem.9b01203},
   keywords = {metallodrug;ruthenium;rotaxane;cucurbituril;anticancer;antimetastatic},
   language = {eng},
   issn = {0020-1669},
   journal = {Inorganic Chemistry},
   title = {Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties},
   url = {http://dx.doi.org/10.1021/acs.inorgchem.9b01203},
   volume = {58},
   year = {2019}
}

TY  - JOUR
ID  - 1547498
AU  - Sojka, Martin - Fojtů, Michaela - Fialová, Jindřiška - Masařík, Michal - Nečas, Marek - Marek, Radek
PY  - 2019
TI  - Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties
JF  - Inorganic Chemistry
VL  - 58
IS  - 16
SP  - 10861-10870
EP  - 10861-10870
PB  - American Chemical Society
SN  - 00201669
KW  - metallodrug;ruthenium;rotaxane;cucurbituril;anticancer;antimetastatic
UR  - http://dx.doi.org/10.1021/acs.inorgchem.9b01203
L2  - http://dx.doi.org/10.1021/acs.inorgchem.9b01203
N2  - We report here the first coupling of Ru(II) units with cucurbit[6/7]uril-based pseudorotaxane ligands meant for biological application. The resulting ruthenium-capped rotaxanes were fully characterized, and a structure of one supramolecular system was determined by X-ray diffraction. Because the biological properties of Ru-based metallodrugs are tightly linked to the ligand-exchange processes, the effect of salt concentration on the hydrolysis of chlorides from the Ru(II) center was monitored by using 1H NMR spectroscopy. The biological activity of Ru(II)-based rotaxanes was evaluated for three selected mammalian breast cell lines, HBL-100, MCF-7, and MDA-MB-231. The antimetastatic activity of the assembled cationic Ru(II)-rotaxane systems, evaluated in migration assays against MCF-7 and MDA-MB-231 cell lines, is notably enhanced compared to that of RAPTA-C, a reference that was used. The indicated synergistic effect of combining Ru(II) with a pseudorotaxane unit opens a new direction in searching for anticancer supramolecular metallodrugs.
ER  -

SOJKA, Martin; Michaela FOJTŮ; Jindřiška FIALOVÁ; Michal MASAŘÍK; Marek NEČAS a Radek MAREK. Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties. \textit{Inorganic Chemistry}. American Chemical Society, 2019, roč.~58, č.~16, s.~10861-10870, 12 s. ISSN~0020-1669. Dostupné z: https://doi.org/10.1021/acs.inorgchem.9b01203.

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