Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based
Rotaxanes with Antimetastatic Properties

J 2019

Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties

SOJKA, Martin, Michaela FOJTŮ, Jindřiška FIALOVÁ, Michal MASAŘÍK, Marek NEČAS et. al.

Základní údaje

Originální název

Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties

Autoři

SOJKA, Martin (203 Česká republika, domácí), Michaela FOJTŮ (203 Česká republika, domácí), Jindřiška FIALOVÁ (203 Česká republika, domácí), Michal MASAŘÍK (203 Česká republika, domácí), Marek NEČAS (203 Česká republika, domácí) a Radek MAREK (203 Česká republika, garant, domácí)

Vydání

Inorganic Chemistry, American Chemical Society, 2019, 0020-1669

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10402 Inorganic and nuclear chemistry

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

DOI: 10.1021/acs.inorgchem.9b01203

Impakt faktor

Impact factor: 4.825

Kód RIV

RIV/00216224:14740/19:00107525

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1021/acs.inorgchem.9b01203

UT WoS

000482173300049

Klíčová slova anglicky

metallodrug;ruthenium;rotaxane;cucurbituril;anticancer;antimetastatic

Štítky

14110515, 14110518, CF NMR, CF SAXS, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 10. 2024 12:35, Ing. Marie Švancarová

Anotace

V originále

We report here the first coupling of Ru(II) units with cucurbit[6/7]uril-based pseudorotaxane ligands meant for biological application. The resulting ruthenium-capped rotaxanes were fully characterized, and a structure of one supramolecular system was determined by X-ray diffraction. Because the biological properties of Ru-based metallodrugs are tightly linked to the ligand-exchange processes, the effect of salt concentration on the hydrolysis of chlorides from the Ru(II) center was monitored by using 1H NMR spectroscopy. The biological activity of Ru(II)-based rotaxanes was evaluated for three selected mammalian breast cell lines, HBL-100, MCF-7, and MDA-MB-231. The antimetastatic activity of the assembled cationic Ru(II)-rotaxane systems, evaluated in migration assays against MCF-7 and MDA-MB-231 cell lines, is notably enhanced compared to that of RAPTA-C, a reference that was used. The indicated synergistic effect of combining Ru(II) with a pseudorotaxane unit opens a new direction in searching for anticancer supramolecular metallodrugs.

Návaznosti

GA15-09381S, projekt VaV

Název: Struktura a vlastnosti paramagnetických komplexů ruthenia pro návrh nových protirakovinných léčiv (Akronym: PARAMAG)

Investor: Grantová agentura ČR, Struktura a vlastnosti paramagnetických komplexů ruthenia pro návrh nových protirakovinných léčiv

GA18-05421S, projekt VaV

Název: Rozvoj paramagnetické NMR spektroskopie pro supramolekulární systémy (Akronym: SUPRAMAG)

Investor: Grantová agentura ČR, Rozvoj paramagnetické NMR spektroskopie pro supramolekulární systémy

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

90043, velká výzkumná infrastruktura

Název: CIISB

Přiložené soubory

IC19_58_10861_acs.inorgchem.9b01203.pdf

Požádat o autorskou verzi souboru

Citovat

SOJKA, Martin, Michaela FOJTŮ, Jindřiška FIALOVÁ, Michal MASAŘÍK, Marek NEČAS a Radek MAREK. Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties. Inorganic Chemistry. American Chemical Society, 2019, roč. 58, č. 16, s. 10861-10870, 12 s. ISSN 0020-1669. Dostupné z: https://dx.doi.org/10.1021/acs.inorgchem.9b01203.

@article{1547498,
   author = {Sojka, Martin and Fojtů, Michaela and Fialová, Jindřiška and Masařík, Michal and Nečas, Marek and Marek, Radek},
   article_number = {16},
   doi = {http://dx.doi.org/10.1021/acs.inorgchem.9b01203},
   keywords = {metallodrug;ruthenium;rotaxane;cucurbituril;anticancer;antimetastatic},
   language = {eng},
   issn = {0020-1669},
   journal = {Inorganic Chemistry},
   title = {Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties},
   url = {http://dx.doi.org/10.1021/acs.inorgchem.9b01203},
   volume = {58},
   year = {2019}
}

TY  - JOUR
ID  - 1547498
AU  - Sojka, Martin - Fojtů, Michaela - Fialová, Jindřiška - Masařík, Michal - Nečas, Marek - Marek, Radek
PY  - 2019
TI  - Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties
JF  - Inorganic Chemistry
VL  - 58
IS  - 16
SP  - 10861-10870
EP  - 10861-10870
PB  - American Chemical Society
SN  - 00201669
KW  - metallodrug;ruthenium;rotaxane;cucurbituril;anticancer;antimetastatic
UR  - http://dx.doi.org/10.1021/acs.inorgchem.9b01203
L2  - http://dx.doi.org/10.1021/acs.inorgchem.9b01203
N2  - We report here the first coupling of Ru(II) units with cucurbit[6/7]uril-based pseudorotaxane ligands meant for biological application. The resulting ruthenium-capped rotaxanes were fully characterized, and a structure of one supramolecular system was determined by X-ray diffraction. Because the biological properties of Ru-based metallodrugs are tightly linked to the ligand-exchange processes, the effect of salt concentration on the hydrolysis of chlorides from the Ru(II) center was monitored by using 1H NMR spectroscopy. The biological activity of Ru(II)-based rotaxanes was evaluated for three selected mammalian breast cell lines, HBL-100, MCF-7, and MDA-MB-231. The antimetastatic activity of the assembled cationic Ru(II)-rotaxane systems, evaluated in migration assays against MCF-7 and MDA-MB-231 cell lines, is notably enhanced compared to that of RAPTA-C, a reference that was used. The indicated synergistic effect of combining Ru(II) with a pseudorotaxane unit opens a new direction in searching for anticancer supramolecular metallodrugs.
ER  -

SOJKA, Martin, Michaela FOJTŮ, Jindřiška FIALOVÁ, Michal MASAŘÍK, Marek NEČAS a Radek MAREK. Locked and Loaded: Ruthenium(II)-Capped Cucurbit[n]uril-Based Rotaxanes with Antimetastatic Properties. \textit{Inorganic Chemistry}. American Chemical Society, 2019, roč.~58, č.~16, s.~10861-10870, 12 s. ISSN~0020-1669. Dostupné z: https://dx.doi.org/10.1021/acs.inorgchem.9b01203.

Podrobný výpis o publikaci